Search Results - "Pinho, Paula Guedes de"

Cardiotoxicity of cyclophosphamide’s metabolites: an in vitro metabolomics approach in AC16 human cardiomyocytes by Dionísio, Flávio, Araújo, Ana Margarida, Duarte-Araújo, Margarida, Bastos, Maria de Lourdes, Guedes de Pinho, Paula, Carvalho, Félix, Costa, Vera Marisa

“…Cyclophosphamide is a widely used anticancer and immunosuppressive prodrug that unfortunately causes severe adverse effects, including cardiotoxicity. Although…”
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Development and optimization of a HS-SPME-GC-MS methodology to quantify volatile carbonyl compounds in Port wines by Moreira, Nathalie, Araújo, Ana Margarida, Rogerson, Frank, Vasconcelos, Isabel, Freitas, Victor De, Pinho, Paula Guedes de

“…•HS-SPME-GC-MS methodology to quantify carbonyl compounds in Port wines.•Optimization and validation of the method was performed.•Optimal SPME conditions were…”
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A Metabolomic Approach for the In Vivo Study of Gold Nanospheres and Nanostars after a Single-Dose Intravenous Administration to Wistar Rats by Enea, Maria, Araújo, Ana Margarida, Almeida, Miguel Peixoto de, Soares, Maria Elisa, Gonçalves-Monteiro, Salomé, Pinho, Paula Guedes de, Pereira, Eulália, Bastos, Maria de Lourdes, Carmo, Helena

“…Gold nanoparticles (AuNPs) are promising nanoplatforms for drug therapy, diagnostic and imaging. However, biological comparison studies for different types of…”
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Identification of a biomarker panel for improvement of prostate cancer diagnosis by volatile metabolic profiling of urine by Lima, Ana Rita, Pinto, Joana, Azevedo, Ana Isabel, Barros-Silva, Daniela, Jerónimo, Carmen, Henrique, Rui, Bastos, Maria de Lourdes, Guedes de Pinho, Paula, Carvalho, Marcia

“…Background: The lack of sensitive and specific biomarkers for the early detection of prostate cancer (PCa) is a major hurdle to improve patient management…”
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Synthetic Cathinones: Recent Developments, Enantioselectivity Studies and Enantioseparation Methods by Almeida, Ana Sofia, Silva, Bárbara, Pinho, Paula Guedes de, Remião, Fernando, Fernandes, Carla

“…New psychoactive substances represent a public health threat since they are not controlled by international conventions, are easily accessible online and are…”
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Metabolomic Signatures of Treatment Response in Bladder Cancer by Vieira de Sousa, Tiago, Guedes de Pinho, Paula, Pinto, Joana

“…Bladder cancer (BC) stands as one of the most prevalent urological malignancies, with over 500 thousand newly diagnosed cases annually. Treatment decisions in…”
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Antimicrobial activity of endophytic fungi from olive tree leaves by Malhadas, Cynthia, Malheiro, Ricardo, Pereira, José Alberto, de Pinho, Paula Guedes, Baptista, Paula

“…In this study, the antimicrobial potential of three fungal endophytes from leaves of Olea europaea L. was evaluated and the host plant extract effect in the…”
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Hepatic Metabolic Derangements Triggered by Hyperthermia: An In Vitro Metabolomic Study by Araújo, Ana Margarida, Enea, Maria, Carvalho, Félix, Bastos, Maria de Lourdes, Carvalho, Márcia, Guedes de Pinho, Paula

“…Background and aims: Liver toxicity is a well-documented and potentially fatal adverse complication of hyperthermia. However, the impact of hyperthermia on the…”
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Biomarker Discovery in Human Prostate Cancer: an Update in Metabolomics Studies by Lima, Ana Rita, Bastos, Maria de Lourdes, Carvalho, Márcia, Guedes de Pinho, Paula

“…Abstract Prostate cancer (PCa) is the most frequently diagnosed cancer and the second leading cause of cancer death among men in Western countries. Current…”
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Metabolomics Reveals Tyrosine Kinase Inhibitor Resistance-Associated Metabolic Events in Human Metastatic Renal Cancer Cells by Amaro, Filipa, Carvalho, Márcia, Bastos, Maria de Lourdes, Guedes de Pinho, Paula, Pinto, Joana

“…The development of resistance to tyrosine kinase inhibitors (TKIs) is a major cause of treatment failure in metastatic renal cell carcinoma (mRCC). A deeper…”
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Discrimination between the human prostate normal and cancer cell exometabolome by GC-MS by Lima, Ana Rita, Araújo, Ana Margarida, Pinto, Joana, Jerónimo, Carmen, Henrique, Rui, Bastos, Maria de Lourdes, Carvalho, Márcia, Guedes de Pinho, Paula

“…Serum prostate-specific antigen (PSA) is currently the most used biomarker in clinical practice for prostate cancer (PCa) detection. However, this biomarker…”
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GC-MS metabolomics-based approach for the identification of a potential VOC-biomarker panel in the urine of renal cell carcinoma patients by Monteiro, Márcia, Moreira, Nathalie, Pinto, Joana, Pires-Luís, Ana S., Henrique, Rui, Jerónimo, Carmen, Bastos, Maria de Lourdes, Gil, Ana M., Carvalho, Marcia, Guedes de Pinho, Paula

“…The analysis of volatile organic compounds (VOCs) emanating from biological samples appears as one of the most promising approaches in metabolomics for the…”
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Advances and Perspectives in Prostate Cancer Biomarker Discovery in the Last 5 Years through Tissue and Urine Metabolomics by Lima, Ana Rita, Pinto, Joana, Amaro, Filipa, Bastos, Maria de Lourdes, Carvalho, Márcia, Guedes de Pinho, Paula

“…Prostate cancer (PCa) is the second most diagnosed cancer in men worldwide. For its screening, serum prostate specific antigen (PSA) test has been largely…”
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Mediterranean Diet-Based Sustainable Healthy Diet and Multicomponent Training Combined Intervention Effect on Body Composition, Anthropometry, and Physical Fitness in Healthy Aging by Sampaio, Joana, Pizarro, Andreia, Pinto, Joana, Oliveira, Bruno, Moreira, André, Padrão, Patrícia, Guedes de Pinho, Paula, Moreira, Pedro, Barros, Renata, Carvalho, Joana

“…Diet and exercise interventions have been associated with improved body composition and physical fitness. However, evidence regarding their combined effects in…”
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Methylone and MDPV activate autophagy in human dopaminergic SH-SY5Y cells: a new insight into the context of β-keto amphetamines-related neurotoxicity by Valente, Maria João, Amaral, Cristina, Correia-da-Silva, Georgina, Duarte, José Alberto, Bastos, Maria de Lourdes, Carvalho, Félix, Guedes de Pinho, Paula, Carvalho, Marcia

“…Autophagy has an essential role in neuronal homeostasis and its dysregulation has been recently linked to neurotoxic effects of a growing list of psychoactive…”
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GC–MS metabolomics reveals disturbed metabolic pathways in primary mouse hepatocytes exposed to subtoxic levels of 3,4-methylenedioxymethamphetamine (MDMA) by Araújo, Ana Margarida, Bastos, Maria de Lourdes, Fernandes, Eduarda, Carvalho, Félix, Carvalho, Marcia, Guedes de Pinho, Paula

“…3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is a well-known hepatotoxic drug. Although its toxicity has been thoroughly studied at high concentrations,…”
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Sunitinib versus Pazopanib Dilemma in Renal Cell Carcinoma: New Insights into the In Vitro Metabolic Impact, Efficacy, and Safety by Amaro, Filipa, Pisoeiro, Carolina, Valente, Maria João, Bastos, Maria de Lourdes, Guedes de Pinho, Paula, Carvalho, Márcia, Pinto, Joana

“…Sunitinib and pazopanib are tyrosine kinase inhibitors (TKIs) used as first-line therapy for metastatic renal cell carcinoma (RCC). Although these TKIs are…”
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A Clinically Relevant Dosage of Mitoxantrone Disrupts the Glutathione and Lipid Metabolic Pathways of the CD-1 Mice Brain: A Metabolomics Study by Dias-Carvalho, Ana, Margarida-Araújo, Ana, Reis-Mendes, Ana, Sequeira, Catarina Oliveira, Pereira, Sofia Azeredo, Guedes de Pinho, Paula, Carvalho, Félix, Sá, Susana Isabel, Fernandes, Eduarda, Costa, Vera Marisa

“…Long-term cognitive dysfunction, or “chemobrain”, has been observed in cancer patients treated with chemotherapy. Mitoxantrone (MTX) is a topoisomerase II…”
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Pharmacometabolomics Applied to Personalized Medicine in Urological Cancers by Amaro, Filipa, Carvalho, Márcia, Bastos, Maria de Lourdes, Guedes de Pinho, Paula, Pinto, Joana

“…Prostate cancer (PCa), bladder cancer (BCa), and renal cell carcinoma (RCC) are the most common urological cancers, and their incidence has been rising over…”
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Doping detection in animals: A review of analytical methodologies published from 1990 to 2019 by moreira, fernando, Carmo, Helena, Pinho, Paula Guedes de, Bastos, Maria de Lourdes

“…Despite the impressive innate physical abilities of horses, camels, greyhounds, or pigeons, doping agents might be administered to these animals to improve…”
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