Search Results - "Pinheiro, Ana Acacia S."

Albumin Expands Albumin Reabsorption Capacity in Proximal Tubule Epithelial Cells through a Positive Feedback Loop between AKT and Megalin by Silva-Aguiar, Rodrigo P, Peruchetti, Diogo B, Florentino, Lucas S, Takiya, Christina M, Marzolo, María-Paz, Dias, Wagner B, Pinheiro, Ana Acacia S, Caruso-Neves, Celso

“…Renal proximal tubule cells (PTECs) act as urine gatekeepers, constantly and efficiently avoiding urinary protein waste through receptor-mediated endocytosis…”
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O-GlcNAcylation in Renal (Patho)Physiology by Silva-Aguiar, Rodrigo P., Peruchetti, Diogo B., Pinheiro, Ana Acacia S., Caruso-Neves, Celso, Dias, Wagner B.

“…Kidneys maintain internal milieu homeostasis through a well-regulated manipulation of body fluid composition. This task is performed by the correlation between…”
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Subclinical Acute Kidney Injury in COVID-19: Possible Mechanisms and Future Perspectives by Silva-Aguiar, Rodrigo P, Teixeira, Douglas E, Peres, Rodrigo A S, Peruchetti, Diogo B, Gomes, Carlos P, Schmaier, Alvin H, Rocco, Patricia R M, Pinheiro, Ana Acacia S, Caruso-Neves, Celso

“…Since the outbreak of COVID-19 disease, a bidirectional interaction between kidney disease and the progression of COVID-19 has been demonstrated. Kidney…”
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PKB and Megalin Determine the Survival or Death of Renal Proximal Tubule Cells by Caruso-Neves, Celso, Pinheiro, Ana Acacia S., Cai, Hui, Souza-Menezes, Jackson, Guggino, William B.

“…Renal proximal tubule cells have a remarkable ability to reabsorb large quantities of albumin through megalin-mediated endocytosis. This is an essential…”
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High Doses of Essential Oil of Croton Zehntneri Induces Renal Tubular Damage by Silva, Katarine F., Peruchetti, Diogo B., Sirtoli, Gabriela M., Takiya, Christina M., Pinheiro, Ana Acacia S., Leal-Cardoso, José Henrique, Caruso-Neves, Celso

“…The essential oil of Croton zehntneri (EOCZ) and its major compounds are known to have several biological activities. However, some evidence shows potential…”
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Synthetic angiotensin II peptide derivatives confer protection against cerebral and severe non-cerebral malaria in murine models by Silva, Adriana F., Torres, Marcelo D. T., Silva, Leandro S., Alves, Flavio L., Miranda, Antonio, Oliveira, Vani X., de la Fuente-Nunez, Cesar, Pinheiro, Ana Acacia S.

“…Malaria can have severe long-term effects. Even after treatment with antimalarial drugs eliminates the parasite, survivors of cerebral malaria may suffer from…”
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The monoterpene 1,8-cineole prevents cerebral edema in a murine model of severe malaria by Santos, Edgleyson C Dos, Silva, Leandro S, Pinheiro, Alessandro S, Teixeira, Douglas E, Peruchetti, Diogo B, Silva-Aguiar, Rodrigo P, Wendt, Camila H C, Miranda, Kildare R, Coelho-de-Souza, Andrelina N, Leal-Cardoso, José Henrique, Caruso-Neves, Celso, Pinheiro, Ana Acacia S

“…1,8-Cineole is a naturally occurring compound found in essential oils of different plants and has well-known anti-inflammatory and antimicrobial activities. In…”
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Lithium ameliorates tubule-interstitial injury through activation of the mTORC2/protein kinase B pathway by Teixeira, Douglas E, Peruchetti, Diogo B, Silva, Leandro S, Silva-Aguiar, Rodrigo P, Oquendo, Morgana B, Silva-Filho, João Luiz, Takiya, Christina M, Leal-Cardoso, José Henrique, Pinheiro, Ana Acacia S, Caruso-Neves, Celso

“…Tubule-interstitial injury (TII) is a critical step in the progression of renal disease. It has been proposed that changes in proximal tubule (PT) albumin…”
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Rapamycin treatment induces tubular proteinuria: role of megalin-mediated protein reabsorption by Peres, Rodrigo A S, Peruchetti, Diogo B, Silva-Aguiar, Rodrigo P, Teixeira, Douglas E, Gomes, Carlos P, Takiya, Christina M, Pinheiro, Ana Acacia S, Caruso-Neves, Celso

“…Rapamycin is an immunosuppressor that acts by inhibiting the serine/threonine kinase mechanistic target of rapamycin complex 1. Therapeutic use of rapamycin is…”
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The angiotensin II/AT1 receptor pathway mediates malaria-induced acute kidney injury by Silva, Leandro S, Peruchetti, Diogo B, Silva-Aguiar, Rodrigo P, Abreu, Thiago P, Dal-Cheri, Beatriz K A, Takiya, Christina M, Souza, Mariana C, Henriques, Maria G, Pinheiro, Ana Acacia S, Caruso-Neves, Celso

“…Malaria-induced acute kidney injury (MAKI) is a life-threatening complication of severe malaria. Here, we investigated the potential role of the angiotensin II…”
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IL-4 Receptor α Chain Protects the Kidney Against Tubule-Interstitial Injury Induced by Albumin Overload by Peruchetti, Diogo B, Silva-Filho, João Luiz, Silva-Aguiar, Rodrigo P, Teixeira, Douglas E, Takiya, Christina M, Souza, Mariana C, Henriques, Maria das Graças, Pinheiro, Ana Acacia S, Caruso-Neves, Celso

“…Increasing evidence has highlighted the role of tubule-interstitial injury (TII) as a vital step in the pathogenesis of acute kidney injury (AKI). Incomplete…”
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Mice rescued from severe malaria are protected against renal injury during a second kidney insult by Abreu, Thiago P, Silva, Leandro S, Takiya, Christina M, Souza, Mariana C, Henriques, Maria G, Pinheiro, Ana Acacia S, Caruso-Neves, Celso

“…Malaria is a worldwide disease that leads to 1 million deaths per year. Plasmodium falciparum is the species responsible for the most severe form of malaria…”
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Changes in angiotensin receptors expression play a pivotal role in the renal damage observed in spontaneously hypertensive rats by Landgraf, Sharon S, Wengert, Mira, Silva, Jaqueline S, Zapata-Sudo, Gisele, Sudo, Roberto T, Takiya, Christina Maeda, Pinheiro, Ana Acacia S, Caruso-Neves, Celso

“…The renal renin-angiotensin system plays a central role in the development of hypertension. The aim of this work was to verify the expression of angiotensin II…”
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LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion by Ribeiro, Marcelle C, Peruchetti, Diogo B, Silva, Leandro S, Silva-Filho, João L, Souza, Mariana C, Henriques, Maria das Graças, Caruso-Neves, Celso, Pinheiro, Ana Acacia S

“…Monocyte adhesion is a crucial step in transmigration and can be induced by lipopolysaccharide (LPS). Here, we studied the role of mammalian target of…”
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Kinins Released by Erythrocytic Stages of Plasmodium falciparum Enhance Adhesion of Infected Erythrocytes to Endothelial Cells and Increase Blood Brain Barrier Permeability via Activation of Bradykinin Receptors by Silva, Leandro S, Pinheiro, Alessandro S, Teixeira, Douglas E, Silva-Aguiar, Rodrigo P, Peruchetti, Diogo B, Scharfstein, Julio, Caruso-Neves, Celso, Pinheiro, Ana Acacia S

“…, the etiologic agent of malaria, is a major cause of infant death in Africa. Although research on the contact system has been revitalized by recent…”
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Inhibition of SGLT2 co-transporter by dapagliflozin ameliorates tubular proteinuria and tubule-interstitial injury at the early stage of diabetic kidney disease by Farias, Raysa S., Silva-Aguiar, Rodrigo P., Teixeira, Douglas E., Gomes, Carlos P., Pinheiro, Ana Acacia S., Peruchetti, Diogo B., Caruso-Neves, Celso

“…Diabetic kidney disease (DKD) is characterized by progressive impairment of kidney function. It has been postulated that tubule-interstitial injury, associated…”
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A high salt diet induces tubular damage associated with a pro-inflammatory and pro-fibrotic response in a hypertension-independent manner by Teixeira, Douglas Esteves, Peruchetti, Diogo B., Souza, Mariana C., das Graças Henriques, Maria G., Pinheiro, Ana Acacia S., Caruso-Neves, Celso

“…High salt diet (HSD), considered a public health problem worldwide, is associated with chronic degenerative diseases including renal diseases. However, little…”
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The angiotensin II/type 1 angiotensin II receptor pathway is implicated in the dysfunction of albumin endocytosis in renal proximal tubule epithelial cells induced by high glucose levels by Afonso, Liz G., Silva-Aguiar, Rodrigo P., Teixeira, Douglas E., Alves, Sarah A.S., Schmaier, Alvin H., Pinheiro, Ana Acacia S., Peruchetti, Diogo B., Caruso-Neves, Celso

“…It is well-established that dysfunction of megalin-mediated albumin endocytosis by proximal tubule epithelial cells (PTECs) and the activation of the…”
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O-GlcNAcylation reduces proximal tubule protein reabsorption and promotes proteinuria in spontaneously hypertensive rats by Silva-Aguiar, Rodrigo Pacheco, Bezerra, Nathália C.F., Lucena, Miguel C., Sirtoli, Gabriela M., Sudo, Roberto T., Zapata-Sudo, Gisele, Takiya, Christina M., Pinheiro, Ana Acacia S., Dias, Wagner Barbosa, Caruso-Neves, Celso

“…Hypertensive individuals are at greater risk for developing chronic kidney disease (CKD). Reducing proteinuria has been suggested as a possible therapeutic…”
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Bradykinin produced during Plasmodium falciparum erythrocytic cycle drives monocyte adhesion to human brain microvascular endothelial cells by Alves, Sarah A S, Teixeira, Douglas E, Peruchetti, Diogo B, Silva, Leandro S, Brandão, Luiz Felipe P, Caruso-Neves, Celso, Pinheiro, Ana Acacia S

“…Cerebral malaria (CM) pathogenesis is described as a multistep mechanism. In this context, monocytes have been implicated in CM pathogenesis by increasing the…”
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