Search Results - "Pinet, Valérie"

The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium by Maurizy, Chloé, Abeza, Claire, Lemmers, Bénédicte, Gabola, Monica, Longobardi, Ciro, Pinet, Valérie, Ferrand, Marina, Paul, Conception, Bremond, Julie, Langa, Francina, Gerbe, François, Jay, Philippe, Verheggen, Céline, Tinari, Nicola, Helmlinger, Dominique, Lattanzio, Rossano, Bertrand, Edouard, Hahne, Michael, Pradet-Balade, Bérengère

“…The R2TP chaperone cooperates with HSP90 to integrate newly synthesized proteins into multi-subunit complexes, yet its role in tissue homeostasis is unknown…”
Get full text

An intestinal TH17 cell-derived subset can initiate cancer by Fesneau, Olivier, Thevin, Valentin, Pinet, Valérie, Goldsmith, Chloe, Vieille, Baptiste, M’Homa Soudja, Saïdi, Lattanzio, Rossano, Hahne, Michael, Dardalhon, Valérie, Hernandez-Vargas, Hector, Benech, Nicolas, Marie, Julien C.

“…Approximately 25% of cancers are preceded by chronic inflammation that occurs at the site of tumor development. However, whether this multifactorial oncogenic…”
Get full text

Loss of primary cilia promotes inflammation and carcinogenesis by Paul, Conception, Tang, Ruizhi, Longobardi, Ciro, Lattanzio, Rossano, Eguether, Thibaut, Turali, Hulya, Bremond, Julie, Maurizy, Chloé, Gabola, Monica, Poupeau, Sophie, Turtoi, Andrei, Denicolai, Emilie, Cufaro, Maria Concetta, Svrcek, Magali, Seksik, Philippe, Castronovo, Vincent, Delvenne, Philippe, de Laurenzi, Vincenzo, Da Costa, Quentin, Bertucci, François, Lemmers, Bénédicte, Pieragostino, Damiana, Mamessier, Emilie, Janke, Carsten, Pinet, Valérie, Hahne, Michael

“…Primary cilia (PC) are important signaling hubs, and we here explored their role in colonic pathology. In the colon, PC are mostly present on fibroblasts, and…”
Get full text

Cyclin A2 maintains colon homeostasis and is a prognostic factor in colorectal cancer by Guo, Yuchen, Gabola, Monica, Lattanzio, Rossano, Paul, Conception, Pinet, Valérie, Tang, Ruizhi, Turali, Hulya, Bremond, Julie, Longobardi, Ciro, Maurizy, Chloé, Da Costa, Quentin, Finetti, Pascal, Boissière-Michot, Florence, Rivière, Benjamin, Lemmers, Céline, Garnier, Séverine, Bertucci, François, Zlobec, Inti, Chebli, Karim, Tazi, Jamal, Azar, Rania, Blanchard, Jean-Marie, Sicinski, Peter, Mamessier, Emilie, Lemmers, Bénédicte, Hahne, Michael

“…To clarify the function of cyclin A2 in colon homeostasis and colorectal cancer (CRC), we generated mice deficient for cyclin A2 in colonic epithelial cells…”
Get full text

Author Correction: The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium by Maurizy, Chloé, Abeza, Claire, Lemmers, Bénédicte, Gabola, Monica, Longobardi, Ciro, Pinet, Valérie, Ferrand, Marina, Paul, Conception, Bremond, Julie, Langa, Francina, Gerbe, François, Jay, Philippe, Verheggen, Céline, Tinari, Nicola, Helmlinger, Dominique, Lattanzio, Rossano, Bertrand, Edouard, Hahne, Michael, Pradet-Balade, Bérengère

Get full text

Lung endothelial barrier disruption in Lyl1-deficient mice by Pirot, Nelly, Delpech, Hélène, Deleuze, Virginie, Dohet, Christiane, Courtade-Saïdi, Monique, Basset-Léobon, Céline, Chalhoub, Elias, Mathieu, Danièle, Pinet, Valérie

“…Maturation of newly formed vessels is a multistep phenomenon during which functional endothelial barriers are established. Disruption of vessel integrity is an…”
Get more information

Angiopoietin-2 is a direct transcriptional target of TAL1, LYL1 and LMO2 in endothelial cells by Deleuze, Virginie, El-Hajj, Rawan, Chalhoub, Elias, Dohet, Christiane, Pinet, Valérie, Couttet, Philippe, Mathieu, Danièle

“…The two related basic helix-loop-helix, TAL1 and LYL1, and their cofactor LIM-only-2 protein (LMO2) are present in blood and endothelial cells. While their…”
Get full text

LYL1 activity is required for the maturation of newly formed blood vessels in adulthood by Pirot, Nelly, Deleuze, Virginie, El-Hajj, Rawan, Dohet, Christiane, Sablitzky, Fred, Couttet, Philippe, Mathieu, Danièle, Pinet, Valérie

“…The 2 related basic helix loop helix genes, LYL1 and TAL-1 are active in hematopoietic and endothelial lineages. While Tal-1 is essential for both…”
Get full text

Deficient Peptide Loading and MHC Class II Endosomal Sorting in a Human Genetic Immunodeficiency Disease: The Chediak-Higashi Syndrome by Faigle, Wolfgang, Raposo, Graça, Tenza, Daniele, Pinet, Valérie, Vogt, Anne B., Kropshofer, Harald, Fischer, Alain, de Saint-Basile, Geneviève, Amigorena, Sebastian

“…The Chediak-Higashi syndrome (CHS) is a human recessive autosomal disease caused by mutations in a single gene encoding a protein of unknown function, called…”
Get full text

Antigen presentation mediated by recycling of surface HLA-DR molecules by Pinet, Valérie, Vergelli, Marco, Martini, Roland, Bakke, Oddmund, Long, Eric O

“…Class II histocompatibility molecules associate with peptides derived from antigens that are processed in endocytic compartments. Antigen presentation to class…”
Get full text

Breast tumor cell soluble factors induce monocytes to produce angiogenic but not angiostatic CXC chemokines by Toulza, Frédéric, Eliaou, Jean‐François, Pinet, Valérie

“…Tumor cells are known to interact closely with nontumoral infiltrating cells in order to grow and proliferate. Monocyte‐derived cells constitute a major…”
Get full text

In Lyl1−/− mice, adipose stem cell vascular niche impairment leads to premature development of fat tissues by Hussain, Abid, Deleuze, Virginie, El Kebriti, Leila, Turali, Hulya, Pirot, Nelly, Glasson, Yaël, Mathieu, Danièle, Pinet, Valérie

“…Lyl1 encodes a hematopoietic‐ and endothelial‐specific bHLH transcription factor. Lyl1‐deficient mice are viable, but they display mild hematopoietic and…”
Get full text

The Down-Regulation of HLA-DM Gene Expression in Rheumatoid Arthritis Is Not Related to Their Promoter Polymorphism by Louis-Plence, Pascale, Kerlan-Candon, Sophie, Morel, Jacques, Combe, Bernard, Clot, Jacques, Pinet, Valerie, Eliaou, Jean-Francois

“…HLA-DM molecule, a class II-like heterodimer, is a critical factor of HLA class II-dependent Ag presentation. It acts as a molecular chaperone and also…”
Get full text

An intestinal T H 17 cell-derived subset can initiate cancer by Fesneau, Olivier, Thevin, Valentin, Pinet, Valérie, Goldsmith, Chloe, Vieille, Baptiste, M'Homa Soudja, Saïdi, Lattanzio, Rossano, Hahne, Michael, Dardalhon, Valérie, Hernandez-Vargas, Hector, Benech, Nicolas, Marie, Julien C

“…Approximately 25% of cancers are preceded by chronic inflammation that occurs at the site of tumor development. However, whether this multifactorial oncogenic…”
Get full text

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells by CELLA, M, ENGERING, A, PINET, V, PIETERS, J, LANZAVECCHIA, A

Get full text

LYL1 activity is required for the maturation of newly formed blood vessels in adulthood by Pirot, Nelly, Deleuze, Virginie, El-Hajj, Rawan, Dohet, Christiane, Sablitzky, Fred, Couttet, Philippe, Mathieu, Danièle, Pinet, Valérie

“…The 2 related basic helix loop helix genes, LYL1 and TAL-1 are active in hematopoietic and endothelial lineages. While Tal-1 is essential for both…”
Get full text

Interferon-α restores HIV-induced alteration of natural killer cell perforin expression in vivo by PORTALES, Pierre, REYNES, Jacques, PINET, Valérie, ROUZIER-PANIS, Régine, BAILLAT, Vincent, CLOT, Jacques, CORBEAU, Pierre

“…The percentage and the activity of natural killer (NK) cells are known to be decreased in HIV-infected patients. However, the mechanisms responsible for this…”
Get full text

Peptide loading onto recycling HLA‐DR molecules occurs in early endosomes by Pinet, Valérie M., Long, Eric O.

“…Presentation of exogenous antigens to MHC class II‐restricted T cells can follow two different processing pathways. The classical pathway requires newly…”
Get full text

Effects of virion surface gp120 density on infection by HIV-1 and viral production by infected cells by Bachrach, Estanislao, Dreja, Hanna, Lin, Yea-Lih, Mettling, Clément, Pinet, Valérie, Corbeau, Pierre, Piechaczyk, Marc

“…The quantity of envelope glycoprotein molecules (Env) on HIV-1 particles is still an issue of debate and, depending on the strain of virus and the nature of…”
Get full text

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells by Cella, Marina, Engering, Anneke, Pinet, Valerie, Pieters, Jean, Lanzavecchia, Antonio

“…Dendritic cells have the remarkable property of presenting any incoming antigen. To do so they must not only capture antigens with high efficiency and broad…”
Get full text