Search Results - "Pinessi, Denise"

Alternative Vascularization Mechanisms in Tumor Resistance to Therapy by Belotti, Dorina, Pinessi, Denise, Taraboletti, Giulia

“…Blood vessels in tumors are formed through a variety of different mechanisms, each generating vessels with peculiar structural, molecular, and functional…”
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Antimetastatic and antiangiogenic activity of trabectedin in cutaneous melanoma by Carminati, Laura, Pinessi, Denise, Borsotti, Patrizia, Minoli, Lucia, Giavazzi, Raffaella, D’Incalci, Maurizio, Belotti, Dorina, Taraboletti, Giulia

“…Abstract Trabectedin is a marine-derived antineoplastic drug. Besides targeting the cancer cells, trabectedin has a peculiar activity on the tumor…”
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Current understanding of the thrombospondin-1 interactome by Resovi, Andrea, Pinessi, Denise, Chiorino, Giovanna, Taraboletti, Giulia

“…The multifaceted action of thrombospondin-1 (TSP-1) depends on its ability to physically interact with different ligands, including structural components of…”
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Abstract 198: The T3R domain of thrombospondin-1 delays tumor growth and improves tumor response to chemotherapy by remodeling the tumor vasculature by Pinessi, Denise, Resovi, Andrea, Morosi, Lavinia, Borsotti, Patrizia, Berndt, Alexander, Giavazzi, Raffaella, Zucchetti, Massimo, Taraboletti, Giulia

“…Abstract The disorganized and inefficient nature of the tumor vasculature affects the delivery and activity of antineoplastic treatments. Certain…”
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The calcium-binding type III repeats domain of thrombospondin-2 binds to fibroblast growth factor 2 (FGF2) by Rusnati, Marco, Borsotti, Patrizia, Moroni, Elisabetta, Foglieni, Chiara, Chiodelli, Paola, Carminati, Laura, Pinessi, Denise, Annis, Douglas S., Paiardi, Giulia, Bugatti, Antonella, Gori, Alessandro, Longhi, Renato, Belotti, Dorina, Mosher, Deane F., Colombo, Giorgio, Taraboletti, Giulia

“…Thrombospondin (TSP)-1 and TSP-2 share similar structures and functions, including a remarkable antiangiogenic activity. We have previously demonstrated that a…”
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Tumor vascular remodeling by thrombospondin-1 enhances drug delivery and antineoplastic activity by Pinessi, Denise, Resovi, Andrea, Sangalli, Fabio, Morosi, Lavinia, Zentilin, Lorena, Borsotti, Patrizia, Carlessi, Elena, Passoni, Alice, Davoli, Enrico, Belotti, Dorina, Giavazzi, Raffaella, Giacca, Mauro, Valbusa, Giovanni, Berndt, Alexander, Zucchetti, Massimo, Taraboletti, Giulia

“…•The abnormal morphological and functional properties of the tumor vasculature are a major hindrance to the distribution and efficacy of antineoplastic…”
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Integrating computational and chemical biology tools in the discovery of antiangiogenic small molecule ligands of FGF2 derived from endogenous inhibitors by Foglieni, Chiara, Pagano, Katiuscia, Lessi, Marco, Bugatti, Antonella, Moroni, Elisabetta, Pinessi, Denise, Resovi, Andrea, Ribatti, Domenico, Bertini, Sabrina, Ragona, Laura, Bellina, Fabio, Rusnati, Marco, Colombo, Giorgio, Taraboletti, Giulia

“…The FGFs/FGFRs system is a recognized actionable target for therapeutic approaches aimed at inhibiting tumor growth, angiogenesis, metastasis, and resistance…”
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Thrombospondin-1 is part of a Slug-independent motility and metastatic program in cutaneous melanoma, in association with VEGFR-1 and FGF-2 by Borsotti, Patrizia, Ghilardi, Carmen, Ostano, Paola, Silini, Antonietta, Dossi, Romina, Pinessi, Denise, Foglieni, Chiara, Scatolini, Maria, Lacal, Pedro M., Ferrari, Raffaele, Moscatelli, Davide, Sangalli, Fabio, D'Atri, Stefania, Giavazzi, Raffaella, Bani, Maria Rosa, Chiorino, Giovanna, Taraboletti, Giulia

“…Summary Differently from most transformed cells, cutaneous melanoma expresses the pleiotropic factor thrombospondin‐1 (TSP‐1). Herein, we show that TSP‐1 (RNA…”
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Expression of thrombospondin-1 by tumor cells in patient-derived ovarian carcinoma xenografts by Pinessi, Denise, Ostano, Paola, Borsotti, Patrizia, Bello, Ezia, Guffanti, Federica, Bizzaro, Francesca, Frapolli, Roberta, Bani, Maria Rosa, Chiorino, Giovanna, Taraboletti, Giulia, Resovi, Andrea

“…Thrombospondin-1 (TSP-1), a major regulator of cell interaction with the environment, is often deregulated in cancers, including ovarian carcinoma. Both the…”
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