Search Results - "Pinelis, V G"

Study on ATP concentration changes in cytosol of individual cultured neurons during glutamate-induced deregulation of calcium homeostasis by Surin, A. M., Gorbacheva, L. R., Savinkova, I. G., Sharipov, R. R., Khodorov, B. I., Pinelis, V. G.

“…For the first time, simultaneous monitoring of changes in the concentration of cytosolic ATP ([ATP] c ), pH (pH c ), and intracellular free Ca 2+ concentration…”
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Activated protein C via PAR1 receptor regulates survival of neurons under conditions of glutamate excitotoxicity by Gorbacheva, L. R., Storozhevykh, T. P., Pinelis, V. G., Davydova, O. N., Ishiwata, S., Strukova, S. M.

“…The effect of an anticoagulant and cytoprotector blood serine proteinase—activated protein C (APC)—on survival of cultured hippocampal and cortical neurons…”
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Disruption of functional activity of mitochondria during MTT assay of viability of cultured neurons by Surin, A. M., Sharipov, R. R., Krasil’nikova, I. A., Boyarkin, D. P., Lisina, O. Yu, Gorbacheva, L. R., Avetisyan, A. V., Pinelis, V. G.

“…The MTT assay based on the reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium in the cell cytoplasm to a strongly light absorbing formazan is…”
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Modulation of hippocampal neuron survival by thrombin and factor Xa by Gorbacheva, L R, Storozhevykh, T P, Pinelis, V G, Ishiwata, S, Strukova, S M

“…Effects of thrombin, factor Xa (FXa), and protease-activated receptor 1 and 2 agonist peptides (PAR1-AP and PAR2-AP) on survival and intracellular Ca2+…”
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Effect of enteropeptidase on survival of cultured hippocampal neurons under conditions of glutamate toxicity by Makarova, A. M, Gorbacheva, L. R, Savinkova, I. V, Mikhailova, A. G, Rumsh, L. D, Pinelis, V. G, Strukova, S. M

“…The effects of full-size bovine enteropeptidase (BEK) and of human recombinant light chain enteropeptidase (L-HEP) on survival of cultured hippocampal neurons…”
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Chitosan-g-oligo(L,L-lactide) copolymer hydrogel for nervous tissue regeneration in glutamate excitotoxicity: in vitro feasibility evaluation by Grebenik, E A, Surin, A M, Bardakova, K N, Demina, T S, Minaev, N V, Veryasova, N N, Artyukhova, M A, Krasilnikova, I A, Bakaeva, Z V, Sorokina, E G, Boyarkin, D P, Akopova, T A, Pinelis, V G, Timashev, P S

“…Over the last decade, a number of hydrogels attracted great attention in the area of brain tissue engineering. The hydrogels are composed of hydrophilic…”
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Insulin Normalizes Ionic Homeostasis and the State of Mitochondria after a Mechanical Damage to the Culture of Brain Neurons by Krasilnikova, I. A., Pomytkin, I. A., Pinelis, V. G., Surin, A. M.

“…Mechanical damage to the primary neuronal culture serves as a convenient in vitro model for studying the molecular and cellular mechanisms involved in the…”
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pH Changes in the Mitochondrial Matrix and Cytosol under Glutamate Deregulation of Ca2+ Homeostasis in Cultured Rat Hippocampal Neurons by Surin, A. M., Gorbacheva, L. R., Savinkova, I. G., Sharipov, R. R., Pinelis, V. G.

“…The effect of high concentrations of glutamate (Glu) on primary cultures of neurons from the rat brain led to a strong depolarization of mitochondria, which…”
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Polymorphism of the APOE Gene and Markers of Brain Damage in the Outcomes of Severe Traumatic Brain Injury in Children by Sorokina, E. G., Semenova, Zh. B., Averianova, N. S., Karaseva, O. V., Arsenieva, E. N., Luk’yanov, V. I., Reutov, V. P., Asanov, A. Yu, Roshal, L. M., Pinelis, V. G.

“…Objective. To compare the genotypes at the apolipoprotein E ( APOE ) gene with outcomes and level of neural markers in children with severe traumatic brain…”
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Neuroprotective Potential of Peptides HFRWPGP (ACTH6–9PGP), KKRRPGP, and PyrRP in Cultured Cortical Neurons at Glutamate Excitotoxicity by Bakaeva, Z. V., Surin, A. M., Lizunova, N. V., Zgodova, A. E., Krasilnikova, I. A., Fisenko, A. P., Frolov, D. A., Andreeva, L. A., Myasoedov, N. F., Pinelis, V. G.

“…Glutamate (Glu) excitotoxicity, which accompanies brain ischemia or traumatic brain injury, is the leading mechanism of neuronal death. In the present work, we…”
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Estimation of time-dependent microRNA expression patterns in brain tissue, leukocytes, and blood plasma of rats under photochemically induced focal cerebral ischemia by Gusar, V. A., Timofeeva, A. V., Zhanin, I. S., Shram, S. I., Pinelis, V. G.

“…miRNA expression over different time periods (24 and 48 h) using the quantitative RT-PCR and deep sequencing has been evaluated in a model of photochemically…”
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Study of the Mechanism of the Neuron Sensitization to the Repeated Glutamate Challenge by Sharipov, R. R., Krasilnikova, I. A., Pinelis, V. G., Gorbacheva, L. R., Surin, A. M.

“…— Exposure of cultured neurons to high concentrations of Glu leads to a strong depolarization of mitochondria, which develops synchronously with the secondary…”
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MicroRNA expression profile in patients in the early stages of ischemic stroke by Zhanin, I. S., Gusar, V. A., Timofeeva, A. T., Pinelis, V. G., Asanov, A. Yu

“…Stroke is one of the leading causes of death and disability in the population, has a complex multifactorial nature and develops through the interaction of…”
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New synthetic peptide protects neurons from death induced by toxic influence of activated mast cells via protease-activated receptor by Babkina, I. I., Strukova, S. M., Pinelis, V. G., Reiser, G., Gorbacheva, L. R.

“…The present study focuses on possible ways to protect brain neurons during neuroinflammation. For the first time it is shown that peptide NPNDKYEPF amide,…”
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Activated protein C and thrombin participate in the regulation of astrocyte functions by Ivanova, A. E., Gorbacheva, L. R., Strukova, S. M., Pinelis, V. G., Reiser, G.

“…Protein C anticoagulant system is a multifunctional cofactor-dependent system. In addition to anticoagulant function, activated protein C (APC) also exhibits…”
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Neuroprotective Effect of KB-R7943 Against Glutamate Excitotoxicity is Related to Mild Mitochondrial Depolarization by Storozhevykh, T. P., Senilova, Ya. E., Brustovetsky, T., Pinelis, V. G., Brustovetsky, N.

“…KB-R7943, an inhibitor of a reversed Na + /Ca 2+ exchanger, exhibits neuroprotection against glutamate excitotoxicity. Taking into consideration that prolonged…”
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Proteinase-activated type 1 receptors are involved in the mechanism of protection of rat hippocampal neurons from glutamate toxicity by Gorbacheva, L R, Storozhevykh, T P, Kiseleva, E V, Pinelis, V G, Strukova, S M

“…Survival of cultured rat hippocampal neurons was estimated 4, 24, and 48 h after 15-min exposure to the toxic effect of glutamate under conditions of pre- or…”
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Effects of Selective Inhibitors of Neuronal and Inducible NO-Synthase on ATP Content and Survival of Cultured Rat Cerebellar Neurons during Hyperstimulation of Glutamate Receptors by Salykina, M. A., Sorokina, E. G., Krasilnikova, I. A., Reutov, V. P., Pinelis, V. G.

“…We studied the effects of selective inhibitors of neuronal and inducible NO-synthase (7-nitroindazole and aminoguanidine) and non-selective NO-synthase…”
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Peptides analogous to tethered ligands liberated by activated protein C exert neuroprotective effects in glutamate-induced excitotoxicity by Savinkova, I. G., Gorbacheva, L. R., Bespalova, Z. D., Pinelis, V. G., Strukova, S. M.

“…Haemostatic proteinases may appear in brain tissue after injury and under inflammation as a result of the blood-brain barrier disruption. Serine proteinases…”
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Biomarkers in children with traumatic brain injury by Pinelis, V G, Sorokina, E G, Semenova, J B, Karaseva, O V, Mescheryakov, S V, Chernisheva, T A, Arsenieva, E N, Roshal, L M

“…to study the content of biomarkers of diagnostic and prognostic value in the assessment of traumatic brain injury (TBI) severity in children. Authors…”
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