Search Results - "Pineiro, David"

G3BP1 interacts directly with the FMDV IRES and negatively regulates translation by Galan, Alfonso, Lozano, Gloria, Piñeiro, David, Martinez‐Salas, Encarnacion

“…RNA–protein interactions play a pivotal role in the function of picornavirus internal ribosome entry site (IRES) elements. Here we analysed the impact of Ras…”
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Supervisory control design for balancing supply and demand in a district heating system with thermal energy storage by Zotică, Cristina, Pérez-Piñeiro, David, Skogestad, Sigurd

“…•The use of inventory (pressure) control is an effective way of balancing supply and demand for a district heating system.•Split range control, controllers…”
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Gemin5 promotes IRES interaction and translation control through its C-terminal region by Piñeiro, David, Fernández, Noemi, Ramajo, Jorge, Martínez-Salas, Encarnación

“…Gene expression control largely depends on ribonucleoprotein complexes regulating mRNA translation. Initiation of translation in mRNAs that overcome…”
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Full-length NF-κB repressing factor contains an XRN2 binding domain by Alexandrova, Jana, Piñeiro, David, Jukes-Jones, Rebekah, Mordue, Ryan, Stoneley, Mark, Willis, Anne E

“…NF-κB repressing factor (NKRF) was recently identified as an RNA binding protein that together with its associated proteins, the 5'-3' exonuclease XRN2 and the…”
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Identification of the RNA polymerase I-RNA interactome by Piñeiro, David, Stoneley, Mark, Ramakrishna, Manasa, Alexandrova, Jana, Dezi, Veronica, Juke-Jones, Rebekha, Lilley, Kathryn S, Cain, Kelvin, Willis, Anne E

“…Abstract Ribosome biogenesis is a complex process orchestrated by a host of ribosome assembly factors. Although it is known that many of the proteins involved…”
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Safety and Efficacy of ApTOLL in Patients With Ischemic Stroke Undergoing Endovascular Treatment: A Phase 1/2 Randomized Clinical Trial by Hernández-Jiménez, Macarena, Abad-Santos, Francisco, Cotgreave, Ian, Gallego, Jaime, Jilma, Bernd, Flores, Alan, Jovin, Tudor G, Vivancos, José, Hernández-Pérez, María, Molina, Carlos A, Montaner, Joan, Casariego, Joaquín, Dalsgaard, Mads, Liebeskind, David S, Cobo, Erik, Castellanos, Mar, Portela, Pere Cardona, Masjuán, Jaime, Moniche, Francisco, Tembl, José Ignacio, Terceño Izaga, Mikel, Arenillas, Juan F, Callejas, Patricia, Olivot, Jean Marc, Calviere, Lionel, Henon, Hilde, Mazighi, Mikael, Piñeiro, David, Pugliese, Marco, González, Victor M, Moro, Maria Angeles, Garcia-Tornel, Alvaro, Lizasoain, Ignacio, Ribo, Marc

“…ApTOLL is a TLR4 antagonist with proven preclinical neuroprotective effect and a safe profile in healthy volunteers. To assess the safety and efficacy of…”
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ApTOLL: A new therapeutic aptamer for cytoprotection and (re)myelination after multiple sclerosis by Fernández‐Gómez, Beatriz, Marchena, Miguel A., Piñeiro, David, Gómez‐Martín, Paula, Sánchez, Estefanía, Laó, Yolanda, Valencia, Gloria, Nocera, Sonia, Benítez‐Fernández, Rocío, Castaño‐León, Ana M., Lagares, Alfonso, Hernández‐Jiménez, Macarena, Castro, Fernando

“…Background and Purpose ApTOLL is an aptamer selected to antagonize toll‐like receptor 4 (TLR4), a relevant actor for innate immunity involved in inflammatory…”
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Gemin5 proteolysis reveals a novel motif to identify L protease targets by Piñeiro, David, Ramajo, Jorge, Bradrick, Shelton S, Martínez-Salas, Encarnación

“…Translation of picornavirus RNA is governed by the internal ribosome entry site (IRES) element, directing the synthesis of a single polyprotein. Processing of…”
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Evolutionary conserved motifs constrain the RNA structure organization of picornavirus IRES by Fernández, Noemí, Buddrus, Lisa, Piñeiro, David, Martínez-Salas, Encarnación

“…•RNA structure impact on internal initiation driven by picornavirus IRES.•Disruption of conserved motifs impairs internal translation initiation.•Structural…”
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Beneficial effect of TLR4 blockade by a specific aptamer antagonist after acute myocardial infarction by Paz-García, Marta, Povo-Retana, Adrián, Jaén, Rafael I., Prieto, Patricia, Peraza, Diego A., Zaragoza, Carlos, Hernandez-Jimenez, Macarena, Pineiro, David, Regadera, Javier, García-Bermejo, María L., Rodríguez-Serrano, E. Macarena, Sánchez-García, Sergio, Moro, María A., Lizasoaín, Ignacio, Delgado, Carmen, Valenzuela, Carmen, Boscá, Lisardo

“…Experimental evidence indicates that the control of the inflammatory response after myocardial infarction is a key strategy to reduce cardiac injury. Cellular…”
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Current Practice in Untargeted Human Milk Metabolomics by Ten-Doménech, Isabel, Ramos-Garcia, Victoria, Piñeiro-Ramos, José David, Gormaz, María, Parra-Llorca, Anna, Vento, Máximo, Kuligowski, Julia, Quintás, Guillermo

“…Human milk (HM) is considered the gold standard for infant nutrition. HM contains macro- and micronutrients, as well as a range of bioactive compounds…”
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Metabolic Phenotypes of Hypoxic-Ischemic Encephalopathy with Normal vs. Pathologic Magnetic Resonance Imaging Outcomes by Piñeiro-Ramos, José David, Núñez-Ramiro, Antonio, Llorens-Salvador, Roberto, Parra-Llorca, Anna, Sánchez-Illana, Ángel, Quintás, Guillermo, Boronat-González, Nuria, Martínez-Rodilla, Juan, Kuligowski, Julia, Vento, Máximo, The Hypotop Study Group

“…Hypoxic-Ischemic Encephalopathy (HIE) is one of the most relevant contributors to neurological disability in term infants. We hypothesized that clinical…”
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The P2 experiment by Becker, Dominik, Bucoveanu, Razvan, Grzesik, Carsten, Imai, Kathrin, Kempf, Ruth, Molitor, Matthias, Tyukin, Alexey, Zimmermann, Marco, Armstrong, David, Aulenbacher, Kurt, Baunack, Sebastian, Beminiwattha, Rakitha, Berger, Niklaus, Bernhard, Peter, Brogna, Andrea, Capozza, Luigi, Silviu Covrig Dusa, Deconinck, Wouter, Diefenbach, Jürgen, Dunne, James, Erler, Jens, Gal, Ciprian, Gericke, Michael, Gläser, Boris, Gorchtein, Mikhail, Gou, Boxing, Gradl, Wolfgang, Imai, Yoshio, Kumar, Krishna S, Maas, Frank, Mammei, Juliette, Pan, Jie, Pandey, Preeti, Paschke, Kent, Perić, Ivan, Pitt, Mark, Rahman, Sakib, Riordan, Seamus, David Rodríguez Piñeiro, Sfienti, Concettina, Sorokin, Iurii, Souder, Paul, Spiesberger, Hubert, Thiel, Michaela, Tyukin, Valery, Weitzel, Quirin

“…We describe the research and development work for the P2 experiment which aims for a high precision determination of the weak mixing angle sin2θW to a…”
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Optimal Operation and Control of a Thermal Energy Storage System: Classical Advanced Control versus Model Predictive Control by Zotica, Cristina, Pérez-Piñeiro, David, Skogestad, Sigurd

“…The objective of this work is to define the optimal operation and control for a thermal storage system with heat sources and a consumer, which exchange…”
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High Concentration of Protein Oxidation Biomarker O-Tyr/Phe Predicts Better Outcome in Childhood Bacterial Meningitis by Rugemalira, Emilie, Roine, Irmeli, Kuligowski, Julia, Sánchez-Illana, Ángel, Piñeiro-Ramos, José David, Andersson, Sture, Cruzeiro, Manuel Leite, Vento, Máximo, Pelkonen, Tuula

“…Neuronal damage in bacterial meningitis (BM) partly stems from the host´s inflammatory response and induced oxidative stress (OS). We studied the association…”
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Alternative Mechanisms to Initiate Translation in Eukaryotic mRNAs by Martinez-Salas, Encarnacion, Pineiro, David, Fernandez, Noemi

“…The composition of the cellular proteome is under the control of multiple processes, one of the most important being translation initiation. The majority of…”
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Protein Oxidation Biomarkers and Myeloperoxidase Activation in Cerebrospinal Fluid in Childhood Bacterial Meningitis by Rugemalira, Emilie, Roine, Irmeli, Kuligowski, Julia, Sánchez-Illana, Ángel, Piñeiro-Ramos, José David, Andersson, Sture, Peltola, Heikki, Leite Cruzeiro, Manuel, Pelkonen, Tuula, Vento, Máximo

“…The immunological response in bacterial meningitis (BM) causes the formation of reactive oxygen and nitrogen species (ROS, RNS) and activates myeloperoxidase…”
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A Reductive Metabolic Switch Protects Infants with Transposition of Great Arteries Undergoing Atrial Septostomy against Oxidative Stress by Piñeiro-Ramos, José David, Rahkonen, Otto, Korpioja, Virpi, Quintás, Guillermo, Pihkala, Jaana, Pitkänen-Argillander, Olli, Rautiainen, Paula, Andersson, Sture, Kuligowski, Julia, Vento, Máximo

“…Transposition of the great arteries (TGA) is one of the most common cyanotic congenital heart diseases requiring neonatal surgical intervention. Parallel…”
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A DNA aptamer population specifically detects Leishmania infantum H2A antigen by Ramos, Edurne, Piñeiro, David, Soto, Manuel, Abanades, Daniel R, Martín, M Elena, Salinas, Matilde, González, Víctor M

“…Aptamers are short single-stranded DNA or RNA oligonucleotides that are selected in vitro by their affinity and specificity for the target. Binding is a…”
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On-Capillary Surface-Enhanced Raman Spectroscopy: Determination of Glutathione in Whole Blood Microsamples by Sánchez-Illana, Ángel, Mayr, Fritz, Cuesta-García, Daniel, Piñeiro-Ramos, José David, Cantarero, Andrés, Guardia, Miguel de la, Vento, Máximo, Lendl, Bernhard, Quintás, Guillermo, Kuligowski, Julia

“…Oxidative stress monitoring in the neonatal period supports early outcome prediction and treatment. Glutathione (GSH) is the most abundant antioxidant in most…”
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