Search Results - "Pindolia, Kirit"

Biotinidase deficiency mimicking neuromyelitis optica: Initially exhibiting symptoms in adulthood by Bottin, Laure, Prud’hon, Sabine, Guey, Stéphanie, Giannesini, Claire, Wolf, Barry, Pindolia, Kirit, Stankoff, Bruno

“…Background: Children with untreated biotinidase deficiency can experience variable symptoms depending on their age of presentation. Older children and…”
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Inhibition of cell proliferation and induction of apoptosis by oleanane triterpenoid (CDDO-Me) in pancreatic cancer cells is associated with the suppression of hTERT gene expression and its telomerase activity by Deeb, Dorrah, Gao, Xiaohua, Liu, Yongbo, Kim, Sahn-Ho, Pindolia, Kirit R., Arbab, Ali S., Gautam, Subhash C.

“…► CDDO-Me inhibits hTERT gene expression. ► CDDO-Me inhibits hTERT protein expression. ► CDDO-Me inhibits hTERT telomerase activity. ► CDDO-Me inhibits hTERT…”
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Neurological deficits in mice with profound biotinidase deficiency are associated with demylination and axonal degeneration by Pindolia, Kirit, Chen, Jieli, Cardwell, Cisley, Cui, Xu, Chopp, Michael, Wolf, Barry

“…Abstract Biotinidase deficiency is an autosomal recessively inherited disorder characterized by neurological and cutaneous abnormalities. We have developed a…”
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Candidate disorders for gene therapy: newborn screening facilitates ascertainment of presymptomatic individuals by Pindolia, Kirit R, Wolf, Barry

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Corrigendum to “First contiguous gene deletion causing biotinidase deficiency: The enzyme deficiency in three Sri Lankan children” [Mol. Genet. Metab. Rep. 2 (2016) 81–84] by Senanayake, Danika Nadeen, Jasinge, Eresha A., Pindolia, Kirit, Wanigasinghe, Jithangi, Monaghan, Kristin, Suchy, Sharon F., Wei, Sainan, Jaysena, Subashini, Wolf, Barry

“…[This corrects the article DOI: 10.1016/j.ymgmr.2015.01.005.]…”
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First contiguous gene deletion causing biotinidase deficiency: The enzyme deficiency in three Sri Lankan children by Senanayake, Danika Nadeen, Jasinge, Eresha. A., Pindolia, Kirit, Wanigasinghe, Jithangi, Monaghan, Kristin, Suchy, Sharon F., Wei, Sainan, Jaysena, Subashini, Wolf, Barry

“…We report three symptomatic children with profound biotinidase deficiency from Sri Lanka. All three children presented with typical clinical features of the…”
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Purification and Characterization of the Simian Virus 40 Transcription Elongation Complex by Pindolia, Kirit R., Lutter, Leonard C.

“…The transcriptional regulatory region of the simian virus 40 minichromosome that is being transcribed in the cell is nucleosome-free, while that of the…”
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Analysis of mutations causing biotinidase deficiency by Pindolia, Kirit, Jordan, Megan, Wolf, Barry

“…Biotinidase deficiency is an inherited disorder in which the vitamin, biotin, is not recycled. Individuals with biotinidase deficiency can develop neurological…”
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Pristimerin, a quinonemethide triterpenoid, induces apoptosis in pancreatic cancer cells through the inhibition of pro-survival Akt/NF-κB/mTOR signaling proteins and anti-apoptotic Bcl-2 by DEEB, DORRAH, GAO, XIAOHUA, LIU, YONG BO, PINDOLIA, KIRIT, GAUTAM, SUBHASH C

“…Lack of effective therapeutics for pancreatic cancer at the present time underscores the dire need for safe and effective agents for the treatment of this…”
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Developmental window of sensorineural deafness in biotinidase-deficient mice by Maheras, Kathleen June, Pindolia, Kirit, Wolf, Barry, Gow, Alexander

“…Biotinidase deficiency is an autosomal recessively inherited disorder that results in the inability to recycle the vitamin, biotin. If untreated, the disorder…”
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Characterization and functional analysis of cellular immunity in mice with biotinidase deficiency by Pindolia, Kirit, Li, Hong, Cardwell, Cisley, Wolf, Barry

“…Biotinidase deficiency is an autosomal recessively inherited metabolic disorder that can be easily and effectively treated with pharmacological doses of the…”
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Ubiquitin-proteasomal degradation of antiapoptotic survivin facilitates induction of apoptosis in prostate cancer cells by pristimerin by LIU, YONG BO, GAO, XIAOHUA, DEEB, DORAH, BRIGOLIN, CHRIS, ZHANG, YIGUAN, SHAW, JIAJIU, PINDOLIA, KIRIT, GAUTAM, SUBHASH C

“…Pristimerin (PM), a quinonemethide triterpenoid, is a promising anticancer agent with potent antiproliferative and apoptosis-inducing activities against cancer…”
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INNV-16. ONCOPATH: OPTIMIZED TREATMENT GUIDELINE CONCORDANT PATHWAY PRESENTED ON A VISUAL-INTERACTIVE DASHBOARD FOR CLINICAL DECISION SUPPORT COMPUTED BY OVERLAYING PATIENT LONGITUDINAL DATA ON A KNOWLEDGE GRAPH by Snyder, James, Alford, Sharon Hensley, Kumar, Tarun, Pindolia, Kirit, Poisson, Laila, Mahatma, Shilpa, Mikkelsen, Tom

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Inhibition of hTERT/telomerase contributes to the antitumor activity of pristimerin in pancreatic ductal adenocarcinoma cells by DEEB, DORRAH, GAO, XIAOHUA, LIU, YONGBO, PINDOLIA, KIRIT, GAUTAM, SUBHASH C

“…Pristimerin (PM) is a promising anticancer agent that has exhibited strong antiproliferative and apoptosis-inducing activity in various types of cancer cells…”
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Analysis of mutations causing biotinidase deficiencya by Pindolia, Kirit, Jordan, Megan, Wolf, Barry

“…Biotinidase deficiency is an inherited disorder in which the vitamin, biotin, is not recycled. Individuals with biotinidase deficiency can develop neurological…”
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Differential gene expression during early development in brains of wildtype and biotinidase-deficient mice by Brigolin, Christian, McKenty, Nathan, Pindolia, Kirit, Wolf, Barry

“…Biotinidase deficiency is an autosomal recessively inherited disorder characterized by neurological and cutaneous abnormalities. Untreated individuals with…”
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Three dimensional structure of human biotinidase: Computer modeling and functional correlations by Pindolia, Kirit, Jensen, Kevin, Wolf, Barry

“…Untreated individuals with deficient activity of biotinidase, the enzyme responsible for recycling the vitamin biotin, usually exhibit neurological and…”
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Development and characterization of a mouse with profound biotinidase deficiency: A biotin-responsive neurocutaneous disorder by Pindolia, Kirit, Jordan, Megan, Guo, Caiying, Matthews, Nell, Mock, Donald M., Strovel, Erin, Blitzer, Miriam, Wolf, Barry

“…Biotinidase deficiency is the primary enzymatic defect in biotin-responsive, late-onset multiple carboxylase deficiency. Untreated children with profound…”
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Role of telomerase in anticancer activity of pristimerin in prostate cancer cells by Liu, Yong Bo, Gao, Xiaohua, Deeb, Dorrah, Pindolia, Kirit, Gautam, Subhash C

“…Pristimerin (PM) is a quinonemethide triterpenoid present in various plant species with strong antiprolifertive and proapoptotic activities in cancer cells…”
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Mutations in the von Hippel-Lindau (VHL) gene refine differential diagnostic criteria in renal cell carcinoma by Barnabas, Nandita, Amin, Mitual B., Pindolia, Kirit, Nanavati, Reshma, Amin, Mahul B., Worsham, Maria J.

“…Background and Objectives Renal cell carcinomas (RCC) with abundant granular cytoplasm include oncocytomas, eosinophillic variants of chromophobe RCC,…”
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