Search Results - "Pinar, Isaac"
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Real-time in vivo imaging of regional lung function in a mouse model of cystic fibrosis on a laboratory X-ray source
Published in Scientific reports (16-01-2020)“…Most measures of lung health independently characterise either global lung function or regional lung structure. The ability to measure airflow and lung…”
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Full Field X-Ray Scatter Tomography
Published in IEEE transactions on medical imaging (01-08-2022)“…In X-ray imaging, photons are transmitted through and absorbed by the target object, but are also scattered in significant quantities. Previous attempts to use…”
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Methods to Determine the Lagrangian Shear Experienced by Platelets during Thrombus Growth
Published in PloS one (14-12-2015)“…Platelets can become activated in response to changes in flow-induced shear; however, the underlying molecular mechanisms are not clearly understood. Here we…”
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Novel Stenotic Microchannels to Study Thrombus Formation in Shear Gradients: Influence of Shear Forces and Human Platelet-Related Factors
Published in International journal of molecular sciences (18-06-2019)“…Thrombus formation in hemostasis or thrombotic disease is initiated by the rapid adhesion, activation, and aggregation of circulating platelets in flowing…”
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Novel imaging approaches for small animal models of lung disease (2017 Grover Conference series)
Published in Pulmonary Circulation (01-04-2018)“…Imaging in small animal models of lung disease is challenging, as existing technologies are limited either by resolution or by the terminal nature of the…”
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Book Review Journal Article -
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In-Vitro Visualization of Thrombus Growth in Artificial Lungs Using Real-Time X-Ray Imaging: A Feasibility Study
Published in Cardiovascular engineering and technology (01-04-2022)“…Purpose Extracorporeal membrane oxygenation has gained increasing attention in the treatment of patients with acute and chronic cardiopulmonary and respiratory…”
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DNA-PKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis
Published in BMC pulmonary medicine (29-08-2019)“…Recent studies have highlighted the contribution of senescent mesenchymal and epithelial cells in Idiopathic Pulmonary Fibrosis (IPF), but little is known…”
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Application of a novel in vivo imaging approach to measure pulmonary vascular responses in mice
Published in Physiological reports (01-09-2018)“…Noninvasive imaging of the murine pulmonary vasculature is challenging due to the small size of the animal, limits of resolution of the imaging technology,…”
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9
Full field X-ray Scatter Tomography
Published 10-03-2022“…In X-ray imaging, photons are transmitted through and absorbed by the subject, but are also scattered in significant quantities. Previous attempts to use…”
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Medicine Meets Mathematics: Measuring ADAM10 Activity Directly On a Forming Thrombus
Published in Blood (15-11-2013)“…Platelets respond rapidly to injury, infection and changes in blood shear stress where they engage subendothelial collagen and von Willebrand Factor via…”
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A‑Disintegrin-And-Metalloproteinase (ADAM) 10 Activity on Resting and Activated Platelets
Published in Biochemistry (Easton) (01-03-2016)“…The primary platelet collagen receptor, glycoprotein VI (GPVI), plays an important role in platelet activation and thrombosis. The ectodomain of human GPVI…”
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