Search Results - "Pina Colarusso"

An introduction to the wound healing assay using live-cell microscopy by Jonkman, James E. N., Cathcart, Judith A., Xu, Feng, Bartolini, Miria E., Amon, Jennifer E., Stevens, Katarzyna M., Colarusso, Pina

“…The wound healing assay is used in a range of disciplines to study the coordinated movement of a cell population. In this technical review, we describe the…”
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Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade by Phillipson, Mia, Heit, Bryan, Colarusso, Pina, Liu, Lixin, Ballantyne, Christie M, Kubes, Paul

“…The prevailing view is that the beta2-integrins Mac-1 (alphaMbeta2, CD11b/CD18) and LFA-1 (alphaLbeta2, CD11a/CD18) serve similar biological functions, namely…”
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Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability by Sahu, Giriraj, Wazen, Rima-Marie, Colarusso, Pina, Chen, S.R. Wayne, Zamponi, Gerald W., Turner, Ray W.

“…The excitability of CA1 hippocampal pyramidal cells is mediated by a slow AHP (sAHP) that responds to calcium increases by Cav1 calcium channels and ryanodine…”
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A biologist's guide to planning and performing quantitative bioimaging experiments by Senft, Rebecca A, Diaz-Rohrer, Barbara, Colarusso, Pina, Swift, Lucy, Jamali, Nasim, Jambor, Helena, Pengo, Thomas, Brideau, Craig, Llopis, Paula Montero, Uhlmann, Virginie, Kirk, Jason, Gonzales, Kevin Andrew, Bankhead, Peter, Evans, 3rd, Edward L, Eliceiri, Kevin W, Cimini, Beth A

“…Technological advancements in biology and microscopy have empowered a transition from bioimaging as an observational method to a quantitative one. However, as…”
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PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils by Kubes, Paul, Heit, Bryan, Robbins, Stephen M, Downey, Charlene M, Guan, Zhiwen, Colarusso, Pina, Miller, B Joan, Jirik, Frank R

“…Leukocytes sense and move in the direction of chemoattractants. Kubes and colleagues show that the phosphatase PTEN is required by migrating neutrophils to…”
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Intravital imaging allows real-time characterization of tissue resident eosinophils by Chojnacki, Andrew, Wojcik, Katarzyna, Petri, Björn, Aulakh, Gurpreet, Jacobsen, Elizabeth A., LeSuer, William E., Colarusso, Pina, Patel, Kamala D.

“…Eosinophils are core components of the immune system, yet tools are lacking to directly observe eosinophils in action in vivo. To better understand the role of…”
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Real-time high resolution 3D imaging of the lyme disease spirochete adhering to and escaping from the vasculature of a living host by Moriarty, Tara J, Norman, M Ursula, Colarusso, Pina, Bankhead, Troy, Kubes, Paul, Chaconas, George

“…Pathogenic spirochetes are bacteria that cause a number of emerging and re-emerging diseases worldwide, including syphilis, leptospirosis, relapsing fever, and…”
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The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction by Ronaghan, Natalie J, Shang, Judie, Iablokov, Vadim, Zaheer, Raza, Colarusso, Pina, Dion, Sébastien, Désilets, Antoine, Leduc, Richard, Turner, Jerrold R, MacNaughton, Wallace K

“…Barrier dysfunction is a characteristic of the inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis. Understanding how the tight junction…”
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Endothelial domes encapsulate adherent neutrophils and minimize increases in vascular permeability in paracellular and transcellular emigration by Phillipson, Mia, Kaur, Jaswinder, Colarusso, Pina, Ballantyne, Christie M, Kubes, Paul

“…Local edema, a cardinal sign of inflammation associates closely with neutrophil emigration. Neutrophil emigration has been described to occur primarily through…”
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Vav1 Is Essential for Mechanotactic Crawling and Migration of Neutrophils out of the Inflamed Microvasculature by Phillipson, Mia, Heit, Bryan, Parsons, Sean A, Petri, Bjorn, Mullaly, Sarah C, Colarusso, Pina, Gower, R. Michael, Neely, Gregory, Simon, Scott I, Kubes, Paul

“…Mac-1-dependent crawling is a new step in the leukocyte recruitment cascade that follows LFA-1-dependent adhesion and precedes emigration. Neutrophil adhesion…”
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Cryptococcus gattii is killed by dendritic cells, but evades adaptive immunity by failing to induce dendritic cell maturation by Huston, Shaunna M, Li, Shu Shun, Stack, Danuta, Timm-McCann, Martina, Jones, Gareth J, Islam, Anowara, Berenger, Byron M, Xiang, Richard F, Colarusso, Pina, Mody, Christopher H

“…During adaptive immunity to pathogens, dendritic cells (DCs) capture, kill, process, and present microbial Ags to T cells. Ag presentation is accompanied by DC…”
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Granule-Dependent NK Cell Killing of Cryptococcus Requires Kinesin to Reposition the Cytolytic Machinery for Directed Cytotoxicity by Ogbomo, Henry, Timm-McCann, Martina, Barnes, Tavish, Xiang, Richard F., Jamil, Khusraw, Ganguly, Anutosh, Stack, Danuta, Huston, Shaunna M., Li, Shu Shun, Colarusso, Pina, Mody, Christopher H.

“…Cryptococcus is the most important cause of fungal meningitis in immunocompromised individuals. Host defense against Cryptococcus involves direct killing by NK…”
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Telomere analysis using 3D fluorescence microscopy suggests mammalian telomere clustering in hTERT-immortalized Hs68 fibroblasts by Adam, Nancy, Degelman, Erin, Briggs, Sophie, Wazen, Rima-Marie, Colarusso, Pina, Riabowol, Karl, Beattie, Tara

“…Telomere length and dynamics are central to understanding cell aging, genomic instability and cancer. Currently, there are limited guidelines for analyzing…”
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Feasibility of three-dimensional facial imaging and printing for producing customised nasal masks for continuous positive airway pressure by Duong, Kelvin, Glover, Joel, Perry, Alexander C, Olmstead, Deborah, Ungrin, Mark, Colarusso, Pina, MacLean, Joanna E, Martin, Andrew R

“…Delivery of continuous positive airway pressure (CPAP) is the standard treatment for obstructive sleep apnoea in children and adults. Treatment adherence is a…”
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Confocal microscopy indentation system for studying in situ chondrocyte mechanics by Han, Sang-Kuy, Colarusso, Pina, Herzog, Walter

“…Abstract Chondrocytes synthesize extracellular matrix molecules, thus they are essential for the development, adaptation and maintenance of articular…”
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Mechanisms by Which Interleukin-12 Corrects Defective NK Cell Anticryptococcal Activity in HIV-Infected Patients by Kyei, Stephen K, Ogbomo, Henry, Li, ShuShun, Timm-McCann, Martina, Xiang, Richard F, Huston, Shaunna M, Ganguly, Anutosh, Colarusso, Pina, Gill, M John, Mody, Christopher H

“…Cryptococcus neoformans is a pathogenic yeast and a leading cause of life-threatening meningitis in AIDS patients. Natural killer (NK) cells are important…”
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The role of capsid-endothelial interactions in the innate immune response to adenovirus vectors by Liu, Qiang, Zaiss, Anne K, Colarusso, Pina, Patel, Kamala, Haljan, Gregory, Wickham, Thomas J, Muruve, Daniel A

“…Adenovirus (Ad) vectors can produce inflammatory responses at high doses. Intravenous administration of an Ad vector expressing green fluorescent protein…”
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Monocyte Surface-Bound IL-15 Can Function as an Activating Receptor and Participate in Reverse Signaling by Neely, Graham G, Epelman, Slava, Ma, Ling Ling, Colarusso, Pina, Howlett, Christopher J, Amankwah, Ernest K, McIntyre, Amanda C, Robbins, Stephen M, Mody, Christopher H

“…IL-15 is a short chain, four-alpha helix cytokine that shares some biological function with IL-2. One striking difference between IL-2 and IL-15 is the ability…”
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Fluorescence Microscopy: A Field Guide for Biologists by Swift, Lucy H, Colarusso, Pina

“…Optical microscopy is a tool for observing objects, and features within objects, that are not visible to the unaided eye. In the life sciences, fluorescence…”
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A biologist’s guide to planning and performing quantitative bioimaging experiments by Rebecca A. Senft, Barbara Diaz-Rohrer, Pina Colarusso, Lucy Swift, Nasim Jamali, Helena Jambor, Thomas Pengo, Craig Brideau, Paula Montero Llopis, Virginie Uhlmann, Jason Kirk, Kevin Andrew Gonzales, Peter Bankhead, Edward L. Evans, Kevin W. Eliceiri, Beth A. Cimini

“…Technological advancements in biology and microscopy have empowered a transition from bioimaging as an observational method to a quantitative one. However, as…”
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