Search Results - "Pimm, M V"

Prevention of renal tubule re-absorption of radiometal (indium-111) labelled Fab fragment of a monoclonal antibody in mice by systemic administration of lysine by Pimm, M V, Gribben, S J

“…Systemic administration of lysine to mice injected with indium-111-labelled Fab fragment of a monoclonal antibody has been shown to reduce renal…”
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Influence of carrier on biodistribution and in vitro cytotoxicity of methotrexate-branched polypeptide conjugates by Hudecz, F, Clegg, J. A, Kajtar, J, Embleton, M. J, Pimm, M. V, Szekerke, M, Baldwin, R. W

“…Methotrexate (MTX) has been conjugated to various structurally related, synthetic, branched polypeptides containing a poly(L-Lys) backbone by the aid of…”
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Circulating antigen: Bad or good for immunoscintigraphy? by Pimm, Malcolm V.

“…There is ample evidence to show that circulating antigen can restrict effective localization of radiolabelled murine monoclonal antibodies in human tumours…”
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An examination of the influence of vasoactive drugs on blood flow and localisation of a monoclonal antibody in human tumour xenografts by PIMM, M. V

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Influence of syngeneic (anti-idiotypic) antibody responses on biodistribution and tumour localisation of murine monoclonal antibodies and fragments by Pimm, M V, Gribben, S J

“…Balb/c mice were immunised with three different syngeneic monoclonal antibodies (Mabs). Following injection of radiolabelled Mabs into mice with anti-antibody…”
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Carrier design: biodistribution of branched polypeptides with a poly(L-lysine) backbone by Clegg, J. A, Hudecz, F, Mezo, G, Pimm, M. V, Szekerke, M, Baldwin, R. W

“…The biodistribution has been examined in mice of a range of synthetic branched polypeptides which are based on a polylysine backbone but which differ in ionic…”
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Drug-monoclonal antibody conjugates for cancer therapy: potentials and limitations by Pimm, M V

“…The development of monoclonal antibodies against antigens associated preferentially with human tumors has reawakened interest in the use of antibodies as…”
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A bispecific monoclonal antibody against methotrexate and a human tumour associated antigen augments cytotoxicity of methotrexate-carrier conjugate by PIMM, M. V, ROBINS, R. A, EMBLETON, M. J, JACOBS, E, MARKHAM, A. J, CHARLESTON, A, BALDWIN, R. W

“…A bispecific monoclonal antibody, reactive with methotrexate (MTX) and a tumour associated antigen (gp72) has been produced by fusing spleen cells from MTX…”
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Immunoscintigraphy of ovarian carcinoma using a monoclonal antibody (111In-NCRC48) defining a polymorphic epithelial mucin (PEM) epitope by Perkins, A C, Symonds, I M, Pimm, M V, Price, M R, Wastie, M L, Symonds, E M

“…An anti-polymorphic epithelial mucin (PEM) monoclonal antibody NCRC48 (IgG3) has been tested for its capacity to localize in tumours according to accepted…”
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Recombinant ricin toxin A chain cytotoxicity against carcinoembryonic antigen expressing tumour cells mediated by a bispecific monoclonal antibody and its potentiation by ricin toxin B chain by EMBLETON, M. J, CHARLESTON, A, ROBINS, R. A, PIMM, M. V, BALDWIN, R. W

“…A bispecific monoclonal antibody recognising both carcinoembryonic antigen (CEA) and ricin toxin A chain (RTA) was tested for its ability to target recombinant…”
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Evaluation of monoclonal idiotypic-specific antibodies as clearing antibodies for enhancement of target localisation by tumour-specific monoclonal antibodies: diversity of effects in nude mice with human tumour xenografts by Pimm, M V, Gribben, S J

“…Three tumour-specific monoclonal antibodies (MoAbs) showed localisation in human tumour xenografts in nude mice, although the tumour discrimination was limited…”
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The Characteristics of Blood-Borne Radiolabels and the Effect of Anti-Mouse IgG Antibodies on Localization of Radiolabeled Monoclonal Antibody in Cancer Patients by Pimm, Malcolm V, Perkins, Alan C, Armitage, Nicholas C, Baldwin, Robert W

“…Quantitative and qualitative aspects of the blood survival of 131I and 111In-labeled monoclonal antibody 791T/36 have been examined in patients with…”
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The influence of syngeneic anti-idiotypic antibody on the biodistribution of an anti-tumour monoclonal antibody in BALB/c mice by Pimm, M V, Durrant, L G, Baldwin, R W

“…BALB/c mice were immunized against syngeneic murine 791T/36 monoclonal antibody (MAb) by intraperitoneal (i.p.) injection of the antibody conjugated to ricin…”
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Toxicity associated with the formation and clearance of immune complexes between antitumour monoclonal antibodies and syngeneic anti-idiotypic antibodies in mice by PIMM, M. V, GRIBBEN, S. J

“…We have previously shown that Balb/c mice immunised against syngeneic monoclonal antibodies (mAbs), so that they have anti-idiotypic responses against those…”
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Influence of syngeneic monoclonal anti-idiotypic antibodies to murine monoclonal antibodies against tumor-associated antigens on the biodistribution of their target antibodies and their fragments by PIMM, M. V, DEMIGNOT, S, GRIBBEN, S. J

“…The effect of syngeneic anti-idiotypic (anti-id) antibodies on the biodistribution of three murine monoclonal antibodies (mAb) against human tumour-associated…”
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Capture of recombinant ricin A chain by a bispecific anti-RTA : anti-CEA monoclonal antibody pre-targeted to a human gastric carcinoma xenograft in nude mice by PIMM, M. V, ROBINS, R. A, BALDWIN, R. W

“…A bispecific antibody against carcinoembryonic antigen (CEA) and ricin A chain has been shown to localise in a CEA-producing human tumour xenograft. When…”
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Targeting of bladder cancer with monoclonal antibody NCRC48--a possible approach for intravesical therapy by Kunkler, R B, Bishop, M C, Green, D J, Pimm, M V, Price, M R, Frier, M

“…To determine the localization of the anti-MUC1 mucin monoclonal antibody (mAb) NCRC48 to bladder cancer following intravesical administration. mAb NCRC48…”
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Tissue retention of indium-labelled antibodies by Perkins, A C, Pimm, M V

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Biodistribution of ricin toxin A chain-monoclonal antibody 791T/36 immunotoxin and influence of hepatic blocking agents by Byers, V S, Pimm, M V, Pawluczyk, I Z, Lee, H M, Scannon, P J, Baldwin, R W

“…Immunotoxin constructed by conjugating ricin A chain to monoclonal antibody 791T/36 has a markedly altered biodistribution when compared to unconjugated…”
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The localization of an anti-tumour monoclonal antibody (791T/36) in gastrointestinal tumours by Armitage, N C, Perkins, A C, Pimm, M V, Farrands, P A, Baldwin, R W, Hardcastle, J D

“…Fifty-six patients with gastrointestinal cancers and four patients with benign colorectal tumours have been injected with radiolabelled anti-tumour monoclonal…”
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