Search Results - "Pimm, Austen D"

1,2-Dihydro-4-quinazolinamines:  Potent, Highly Selective Inhibitors of Inducible Nitric Oxide Synthase Which Show Antiinflammatory Activity in Vivo by Tinker, Alan C, Beaton, Haydn G, Boughton-Smith, Nigel, Cooper, Sally L, Fraser-Rae, Lynne, Hallam, Kay, Hamley, Peter, McInally, Tom, Nicholls, David J, Pimm, Austen D, Wallace, Alan V

“…The discovery of a novel class of nitric oxide synthase (NOS) inhibitors, 2-substituted 1,2-dihydro-4-quinazolinamines, and the related…”
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The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS) by Cheshire, David R., Åberg, Anders, Andersson, Gunilla M.K., Andrews, Glen, Beaton, Haydn G., Birkinshaw, Timothy N., Boughton-Smith, Nigel, Connolly, Stephen, Cook, Tony R., Cooper, Anne, Cooper, Sally L., Cox, David, Dixon, John, Gensmantel, Nigel, Hamley, Peter J., Harrison, Richard, Hartopp, Paul, Käck, Helena, Leeson, Paul D., Luker, Timothy, Mete, Antonio, Millichip, Ian, Nicholls, David J., Pimm, Austen D., St-Gallay, Steve A., Wallace, Alan V.

“…By careful analysis of experimental X-ray ligand crystallographic protein data across several inhibitor series we have discovered a novel, potent and selective…”
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Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X7 Receptor Antagonists/Interleukin-1β Inhibitors by Furber, Mark, Alcaraz, Lilian, Bent, Janice E, Beyerbach, Armin, Bowers, Keith, Braddock, Martin, Caffrey, Moya V, Cladingboel, David, Collington, John, Donald, David K, Fagura, Malbinder, Ince, Frank, Kinchin, Elizabeth C, Laurent, Celine, Lawson, Mandy, Luker, Timothy J, Mortimore, Michael M. P, Pimm, Austen D, Riley, Robert J, Roberts, Nicola, Robertson, Mark, Theaker, Jill, Thorne, Philip V, Weaver, Richard, Webborn, Peter, Willis, Paul

“…A novel series of antagonists of the human P2X7 receptor is described. Modification of substituents enabled identification of compounds selective for the rat…”
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Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X 7 Receptor Antagonists/Interleukin-1β Inhibitors by Furber, Mark, Alcaraz, Lilian, Bent, Janice E., Beyerbach, Armin, Bowers, Keith, Braddock, Martin, Caffrey, Moya V., Cladingboel, David, Collington, John, Donald, David K., Fagura, Malbinder, Ince, Frank, Kinchin, Elizabeth C., Laurent, Celine, Lawson, Mandy, Luker, Timothy J., Mortimore, Michael M. P., Pimm, Austen D., Riley, Robert J., Roberts, Nicola, Robertson, Mark, Theaker, Jill, Thorne, Philip V., Weaver, Richard, Webborn, Peter, Willis, Paul

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Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors by Furber, Mark, Alcaraz, Lilian, Bent, Janice E, Beyerbach, Armin, Bowers, Keith, Braddock, Martin, Caffrey, Moya V, Cladingboel, David, Collington, John, Donald, David K, Fagura, Malbinder, Ince, Frank, Kinchin, Elizabeth C, Laurent, Celine, Lawson, Mandy, Luker, Timothy J, Mortimore, Michael M P, Pimm, Austen D, Riley, Robert J, Roberts, Nicola, Robertson, Mark, Theaker, Jill, Thorne, Philip V, Weaver, Richard, Webborn, Peter, Willis, Paul

“…A novel series of antagonists of the human P2X7 receptor is described. Modification of substituents enabled identification of compounds selective for the rat…”
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