Search Results - "Pimentel, Natalia"
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CNS-wide repopulation by hematopoietic-derived microglia-like cells corrects progranulin deficiency in mice
Published in Nature communications (05-07-2024)“…Hematopoietic stem cell transplantation can deliver therapeutic proteins to the central nervous system (CNS) through transplant-derived microglia-like cells…”
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Neonatal nonviral gene editing with the CRISPR/Cas9 system improves some cardiovascular, respiratory, and bone disease features of the mucopolysaccharidosis I phenotype in mice
Published in Gene therapy (01-02-2020)“…Mucopolysaccharidosis type I (MPS I) is caused by deficiency of alpha-L-iduronidase (IDUA), leading to multisystemic accumulation of glycosaminoglycans (GAG)…”
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Brain and visceral gene editing of mucopolysaccharidosis I mice by nasal delivery of the CRISPR/Cas9 system
Published in The journal of gene medicine (01-04-2022)“…Background Mucopolysaccharidosis type I (MPS I) is an inherited disease caused by deficiency of the enzyme alpha‐l‐iduronidase (IDUA). MPS I affects several…”
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Nanostructured titanium alloy surfaces for enhanced osteoblast response: A combination of morphology and chemistry
Published in Surface & coatings technology (15-02-2020)“…This study is part of a new trend in the metallic biomaterials field that searches to use the titanium beta alloys with recognized bulk and surface properties…”
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Effect of genistein and coenzyme Q10 in oxidative damage and mitochondrial membrane potential in an attenuated type II mucopolysaccharidosis cellular model
Published in Cell biochemistry and function (01-03-2024)“…Mucopolysaccharidosis type II (MPS II) is an inborn error of the metabolism resulting from several possible mutations in the gene coding for…”
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Causal validation of the risk for corneal injury in critically ill adults
Published in Nursing in critical care (01-11-2023)“…The validity of a nursing diagnosis depends on a continuous investigation process in different populations to provide clinical evidence. The risk for corneal…”
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In Situ Gene Therapy
Published in Current gene therapy (01-01-2021)“…Gene therapy is a technique that aims at the delivery of nucleic acids to cells, to obtain a therapeutic effect. In situ gene therapy consists of the…”
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The laura and coenobium of Saint Pedro of Rocas. A rupestrian complex of Byzantine origin in the northwest of the Iberian Peninsula
Published in Anastasis (Iaşi) (29-05-2020)“…The building we see today when we approach the monastery of Saint Pedro of Rocas reveals the modern architecture: the priory house. But this architecture…”
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Risk for corneal injury in intensive care unit patients: A cohort study
Published in Intensive & critical care nursing (01-06-2021)“…•Critically ill patients are more vulnerable to corneal injury.•Lagophthalmos and chemosis contribute to the development of corneal injury.•An eye care…”
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Validation of educational technology for the prevention and control of contact-borne infections
Published in Rev. RENE (01-01-2021)“…Objective: to build and validate the content and appearance of the booklet on prevention and control of contact-borne infections. Methods: methodological…”
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Human recombinant lysosomal enzymes produced in microorganisms
Published in Molecular genetics and metabolism (01-09-2015)“…Lysosomal storage diseases (LSDs) are caused by accumulation of partially degraded substrates within the lysosome, as a result of a function loss of a…”
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Different culture conditions applied to in vitro shoot multiplication of two Eucalyptus benthamii explant sources
Published in Journal of forestry research (01-06-2020)“…Eucalyptus adult material requires more successive subcultures in the in vitro multiplication phase for increased vigor and cellular activity. This study…”
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Contaminação versus manifestação endofítica: implicações no cultivo in vitro de plantas
Published in Rodriguésia (2020)“…Resumo A cultura de tecidos vegetais é imprescindível à propagação e multiplicação uniforme de plantas, à conservação de germoplasma, a programas de…”
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Identification of the iduronate-2-sulfatase proteome in wild-type mouse brain
Published in Heliyon (01-05-2019)“…Iduronate-2-sulfatase (IDS) is a lysosomal enzyme involved in the metabolism of the glycosaminoglycans heparan (HS) and dermatan (DS) sulfate. Mutations on IDS…”
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Characterization of heart disease in mucopolysaccharidosis type II mice
Published in Cardiovascular pathology (01-11-2023)“…•Mucopolysaccharidosis type II leads to progressive loss of cardiac function.•Iduronate-2-sulfatase enzyme deficiency causes damage to the cardiovascular…”
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Antifungal Activity and Biocompatibility of α-AgVO3, α-Ag2WO4, and β-Ag2MoO4 Using a Three-Dimensional Coculture Model of the Oral Mucosa
Published in Frontiers in bioengineering and biotechnology (14-02-2022)“…Fungal infections have become a major concern in the medical community, especially those caused by Candida spp. Within this species, Candida albicans stands…”
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Educational technologies for people living with hepatitis B: integrative review
Published in Rev. RENE (01-01-2019)“…Objective: to identify the educational technologies used and/or validated for people living with hepatitis B. Methods: integrative literature review conducted…”
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Identification of Ezetimibe and Pranlukast as Pharmacological Chaperones for the Treatment of the Rare Disease Mucopolysaccharidosis Type IVA
Published in Journal of medicinal chemistry (11-07-2019)“…Mucopolysaccharidosis type IVA (MPS IVA) is a rare disease caused by mutations in the gene encoding the lysosomal enzyme N-acetylgalactosamine-6-sulfate…”
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Increasing the photocatalytic and fungicide activities of Ag3PO4 microcrystals under visible-light irradiation
Published in Ceramics international (15-08-2021)“…The present study reports for the first time the performance of silver phosphate (Ag3PO4) microcrystals as photocatalyst (degradation of Rodamine B-RhB) and…”
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Mechanism of Antibacterial Activity via Morphology Change of α‑AgVO3: Theoretical and Experimental Insights
Published in ACS applied materials & interfaces (05-04-2017)“…The electronic configuration, morphology, optical features, and antibacterial activity of metastable α-AgVO3 crystals have been discussed by a conciliation and…”
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