Search Results - "Pimanda, J E"

Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias by Tursky, M L, Beck, D, Thoms, J A I, Huang, Y, Kumari, A, Unnikrishnan, A, Knezevic, K, Evans, K, Richards, L A, Lee, E, Morris, J, Goldberg, L, Izraeli, S, Wong, J W H, Olivier, J, Lock, R B, MacKenzie, K L, Pimanda, J E

“…High expression of the ETS family transcription factor ERG is associated with poor clinical outcome in acute myeloid leukemia (AML) and acute T-cell…”
Get full text

MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation by Huang, Y, Thoms, J A I, Tursky, M L, Knezevic, K, Beck, D, Chandrakanthan, V, Suryani, S, Olivier, J, Boulton, A, Glaros, E N, Thomas, S R, Lock, R B, MacKenzie, K L, Bushweller, J H, Wong, J W H, Pimanda, J E

“…Aberrant ERG (v-ets avian erythroblastosis virus E26 oncogene homolog) expression drives leukemic transformation in mice and high expression is associated with…”
Get full text

A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients by Oram, S H, Thoms, J A I, Pridans, C, Janes, M E, Kinston, S J, Anand, S, Landry, J -R, Lock, R B, Jayaraman, P -S, Huntly, B J, Pimanda, J E, Göttgens, B

“…The T-cell oncogene Lim-only 2 (LMO2) critically influences both normal and malignant haematopoiesis. LMO2 is not normally expressed in T cells, yet ectopic…”
Get full text

AZA-MS: a novel multiparameter mass spectrometry method to determine the intracellular dynamics of azacitidine therapy in vivo by Unnikrishnan, A, Vo, A N Q, Pickford, R, Raftery, M J, Nunez, A C, Verma, A, Hesson, L B, Pimanda, J E

“…The cytidine analogue, 5-azacytidine (AZA; 5-AZA-cR), is the primary treatment for myelodysplastic syndrome and chronic myelomonocytic leukaemia. However, only…”
Get full text

A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients by Beck, D, Thoms, J A I, Palu, C, Herold, T, Shah, A, Olivier, J, Boelen, L, Huang, Y, Chacon, D, Brown, A, Babic, M, Hahn, C, Perugini, M, Zhou, X, Huntly, B J, Schwarzer, A, Klusmann, J-H, Berdel, W E, Wörmann, B, Büchner, T, Hiddemann, W, Bohlander, S K, To, L B, Scott, H S, Lewis, I D, D'Andrea, R J, Wong, J W H, Pimanda, J E

“…Prognostic gene expression signatures have been proposed as clinical tools to clarify therapeutic options in acute myeloid leukemia (AML). However, these…”
Get full text

Bivalent promoter marks and a latent enhancer may prime the leukaemia oncogene LMO1 for ectopic expression in T-cell leukaemia by Oram, S H, Thoms, J, Sive, J I, Calero-Nieto, F J, Kinston, S J, Schütte, J, Knezevic, K, Lock, R B, Pimanda, J E, Göttgens, B

“…LMO1 is a transcriptional regulator and a T-acute lymphoblastic leukaemia (T-ALL) oncogene. Although first identified in association with a chromosomal…”
Get full text

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo by Woll, Petter S., Kjällquist, Una, Chowdhury, Onima, Doolittle, Helen, Wedge, David C., Thongjuea, Supat, Erlandsson, Rikard, Ngara, Mtakai, Anderson, Kristina, Deng, Qiaolin, Mead, Adam J., Stenson, Laura, Giustacchini, Alice, Duarte, Sara, Giannoulatou, Eleni, Taylor, Stephen, Karimi, Mohsen, Scharenberg, Christian, Mortera-Blanco, Teresa, Macaulay, Iain C., Clark, Sally-Ann, Dybedal, Ingunn, Josefsen, Dag, Fenaux, Pierre, Hokland, Peter, Holm, Mette S., Cazzola, Mario, Malcovati, Luca, Tauro, Sudhir, Bowen, David, Boultwood, Jacqueline, Pellagatti, Andrea, Pimanda, John E., Unnikrishnan, Ashwin, Vyas, Paresh, Göhring, Gudrun, Schlegelberger, Brigitte, Tobiasson, Magnus, Kvalheim, Gunnar, Constantinescu, Stefan N., Nerlov, Claus, Nilsson, Lars, Campbell, Peter J., Sandberg, Rickard, Papaemmanuil, Elli, Hellström-Lindberg, Eva, Linnarsson, Sten, Jacobsen, Sten Eirik W.

“…Evidence for distinct human cancer stem cells (CSCs) remains contentious and the degree to which different cancer cells contribute to propagating malignancies…”
Get full text

RNA Splicing Alterations Induce a Cellular Stress Response Associated with Poor Prognosis in Acute Myeloid Leukemia by Anande, Govardhan, Deshpande, Nandan P, Mareschal, Sylvain, Batcha, Aarif M N, Hampton, Henry R, Herold, Tobias, Lehmann, Soren, Wilkins, Marc R, Wong, Jason W H, Unnikrishnan, Ashwin, Pimanda, John E

“…RNA splicing is a fundamental biological process that generates protein diversity from a finite set of genes. Recurrent somatic mutations of splicing factor…”
Get full text

Genome-wide transcription factor–binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs by Subramanian, Shruthi, Thoms, Julie A. I., Huang, Yizhou, Cornejo-Páramo, Paola, Koch, Forrest C., Jacquelin, Sebastien, Shen, Sylvie, Song, Emma, Joshi, Swapna, Brownlee, Chris, Woll, Petter S., Chacon-Fajardo, Diego, Beck, Dominik, Curtis, David J., Yehson, Kenneth, Antonenas, Vicki, O'Brien, Tracey, Trickett, Annette, Powell, Jason A., Lewis, Ian D., Pitson, Stuart M., Gandhi, Maher K., Lane, Steven W., Vafaee, Fatemeh, Wong, Emily S., Göttgens, Berthold, Alinejad-Rokny, Hamid, Wong, Jason W. H., Pimanda, John E.

“…•Heptad TF occupancy is highly dynamic across HSPC subsets and associated with cell-type–specific gene expression.•Enhancers with cell-type–specific heptad…”
Get full text

Comparative Analysis of Genome-Scale Gene Regulatory Networks in Human Hematopoietic Stem and Myeloid Progenitor Fractions by Subramanian, Shruthi, Thoms, Julie A.I., Huang, Yizhou, Jacquelin, Sebastien, Shen, Sylvie, Song, Emma, Joshi, Swapna, Brownlee, Chris, Woll, Petter S, Fajardo, Diego Chacon, Beck, Dominik, Curtis, David J., Yehson, Kenneth, Antonenas, Vicki, Brien, Tracey O', Trickett, Annette, Powell, Jason, Pitson, Stuart M, Gandhi, Maher K., Cornejo, Paola, Wong, Emily, Lane, Steven W, Gottgens, Bertie, Rokny, Hamid Alinejad, Wong, Jason W.H, Pimanda, John E.

Get full text

Gene regulatory networks governing haematopoietic stem cell development and identity by Pimanda, John E, Göttgens, Berthold

“…Development can be viewed as a dynamic progression through regulatory states which characterise the various cell types within a given differentiation cascade…”
Get full text

The proto-oncogene ERG in megakaryoblastic leukemias by RAINIS, Liat, TOKI, Tsutomu, PIMANDA, John E, ROSENTHAL, Ester, MACHOL, Keren, STREHL, Sabine, GÖTTGENS, Berthold, ITO, Etsuro, IZRAELI, Shai

“…Aneuploidy is one of the hallmarks of cancer. Acquired additions of chromosome 21 are a common finding in leukemias, suggesting a contributory role to…”
Get full text

Mutations in Histone Modulators and HOXA5 Methylation Levels Affects Survival in Azacitidine Treated MDS Patients by Tobiasson, Magnus, Karimi, Mohsen, Dimitriou, Marios, Qu, Ying, Lennartsson, Andreas, Abdulkadir Ali, Hani, Unnikrishnan, Ashwin, Jadersten, Martin, Jansson, Monika, Ben Azenkoud, Asmaa, Pimanda, John E, Ekwall, Karl, Ungerstedt, Johanna, Lehmann, Soren, Hellstrom-Lindberg, Eva

“…Introduction: Azacytidine (Aza) is first-line treatment for patients with higher-risk MDS but only around 50% of patients respond to therapy. Overall survival…”
Get full text

An Integrative Genomics Approach Uncovers the Basis of Resistance to AZA Therapy in MDS and CMML by Unnikrishnan, Ashwin, Papaemmanuil, Elli, Beck, Dominik, Verma, Arjun, Kumari, Ashu, Richards, Laura A., Knezevic, Kathy, Chandrakanthan, Vashe, Thoms, Julie A.I., Tursky, Melinda L., Huang, Yizhou, Galbraith, Sally, Kulasekararaj, Austin G., Tobiasson, Magnus, Woll, Petter S., Pellagatti, Andrea, Wilson, Susan R., Lindeman, Robert, Boultwood, Jacqueline, Lynch, Kevin, Jacobsen, Sten Eirik, Mufti, Ghulam J, Hellstrom-Lindberg, Eva, Mackenzie, Karen Lee, Wong, Jason W.H., Campbell, Peter J, Pimanda, John E.

“…▪ Background: Myelodysplastic Syndrome (MDS) and Chronic Myelomonocytic Leukaemia (CMML) are haematological disorders that develop in haematopoietic stem or…”
Get full text

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo by Woll, Petter S., Kjällquist, Una, Chowdhury, Onima, Doolittle, Helen, Wedge, David C., Thongjuea, Supat, Erlandsson, Rikard, Ngara, Mtakai, Anderson, Kristina, Deng, Qiaolin, Mead, Adam J., Stenson, Laura, Giustacchini, Alice, Duarte, Sara, Giannoulatou, Eleni, Taylor, Stephen, Karimi, Mohsen, Scharenberg, Christian, Mortera-Blanco, Teresa, Macaulay, Iain C., Clark, Sally-Ann, Dybedal, Ingunn, Josefsen, Dag, Fenaux, Pierre, Hokland, Peter, Holm, Mette S., Cazzola, Mario, Malcovati, Luca, Tauro, Sudhir, Bowen, David, Boultwood, Jacqueline, Pellagatti, Andrea, Pimanda, John E., Unnikrishnan, Ashwin, Vyas, Paresh, Göhring, Gudrun, Schlegelberger, Brigitte, Tobiasson, Magnus, Kvalheim, Gunnar, Constantinescu, Stefan N., Nerlov, Claus, Nilsson, Lars, Campbell, Peter J., Sandberg, Rickard, Papaemmanuil, Elli, Hellström-Lindberg, Eva, Linnarsson, Sten, Jacobsen, Sten Eirik W.

Get full text

Congenital thrombotic thrombocytopenic purpura in association with a mutation in the second CUB domain of ADAMTS13 by Pimanda, John E., Maekawa, Akiko, Wind, Troels, Paxton, Julian, Chesterman, Colin N., Hogg, Philip J.

“…Severe deficiency of the von Willebrand Factor (VWF)–cleaving proteinase, ADAMTS13, is associated with the development of thrombotic thrombocytopenic purpura…”
Get full text

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo by Woll, Petter S., Kjällquist, Una, Chowdhury, Onima, Doolittle, Helen, Wedge, David C., Thongjuea, Supat, Erlandsson, Rikard, Ngara, Mtakai, Anderson, Kristina, Deng, Qiaolin, Mead, Adam J., Stenson, Laura, Giustacchini, Alice, Duarte, Sara, Giannoulatou, Eleni, Taylor, Stephen, Karimi, Mohsen, Scharenberg, Christian, Mortera-Blanco, Teresa, Macaulay, Iain C., Clark, Sally-Ann, Dybedal, Ingunn, Josefsen, Dag, Fenaux, Pierre, Hokland, Peter, Holm, Mette S., Cazzola, Mario, Malcovati, Luca, Tauro, Sudhir, Bowen, David, Boultwood, Jacqueline, Pellagatti, Andrea, Pimanda, John E., Unnikrishnan, Ashwin, Vyas, Paresh, Göhring, Gudrun, Schlegelberger, Brigitte, Tobiasson, Magnus, Kvalheim, Gunnar, Constantinescu, Stefan N., Nerlov, Claus, Nilsson, Lars, Campbell, Peter J., Sandberg, Rickard, Papaemmanuil, Elli, Hellström-Lindberg, Eva, Linnarsson, Sten, Jacobsen, Sten Eirik W.

Get full text

Role of Thrombospondin-1 in Control of von Willebrand Factor Multimer Size in Mice by Pimanda, John E, Ganderton, Tim, Maekawa, Akiko, Yap, Cindy L, Lawler, Jack, Kershaw, Geoff, Chesterman, Colin N, Hogg, Philip J

“…Plasma von Willebrand factor (VWF) is a multimeric glycoprotein from endothelial cells and platelets that mediates adhesion of platelets to sites of vascular…”
Get full text

Transcriptional Link between Blood and Bone: the Stem Cell Leukemia Gene and Its +19 Stem Cell Enhancer Are Active in Bone Cells by Pimanda, John E., Silberstein, Lev, Dominici, Massimo, Dekel, Benjamin, Bowen, Mark, Oldham, Scott, Kallianpur, Asha, Brandt, Stephen J., Tannahill, David, Göttgens, Berthold, Green, Anthony R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

A perspective on the measurement of ADAMTS13 in thrombotic thrombocytopaenic purpura by Pimanda, John E., Chesterman, Colin N., Hogg, Philip J.

“…: The recent discovery of the von Willebrand Factor (vWF) cleaving protease (ADAMTS13) and the association of its deficiency with thrombotic thrombocytopaenic…”
Get full text