Search Results - "Pils, Marina C"

Interleukin-10 Signaling in Regulatory T Cells Is Required for Suppression of Th17 Cell-Mediated Inflammation by Chaudhry, Ashutosh, Samstein, Robert M., Treuting, Piper, Liang, Yuqiong, Pils, Marina C., Heinrich, Jan-Michael, Jack, Robert S., Wunderlich, F. Thomas, Brüning, Jens C., Müller, Werner, Rudensky, Alexander Y.

“…Effector CD4 + T cell subsets, whose differentiation is facilitated by distinct cytokine cues, amplify the corresponding type of inflammatory response…”
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Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation by Iljazovic, Aida, Roy, Urmi, Gálvez, Eric J. C., Lesker, Till R., Zhao, Bei, Gronow, Achim, Amend, Lena, Will, Sabine E., Hofmann, Julia D., Pils, Marina C., Schmidt-Hohagen, Kerstin, Neumann-Schaal, Meina, Strowig, Till

“…Diverse microbial signatures within the intestinal microbiota have been associated with intestinal and systemic inflammatory diseases, but whether these…”
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Variations in microbiota composition of laboratory mice influence Citrobacter rodentium infection via variable short-chain fatty acid production by Osbelt, Lisa, Thiemann, Sophie, Smit, Nathiana, Lesker, Till Robin, Schröter, Madita, Gálvez, Eric J C, Schmidt-Hohagen, Kerstin, Pils, Marina C, Mühlen, Sabrina, Dersch, Petra, Hiller, Karsten, Schlüter, Dirk, Neumann-Schaal, Meina, Strowig, Till

“…The composition of the intestinal microbiota influences the outcome of enteric infections in human and mice. However, the role of specific members and their…”
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Zfp362 potentiates murine colonic inflammation by constraining Treg cell function rather than promoting Th17 cell differentiation by Herppich, Susanne, Hoenicke, Lisa, Kern, Fabian, Kruse, Friederike, Smout, Justine, Greweling‐Pils, Marina C., Geffers, Robert, Burton, Oliver T., Liston, Adrian, Keller, Andreas, Floess, Stefan, Huehn, Jochen

“…Mucosal barrier integrity and pathogen clearance is a complex process influenced by both Th17 and Treg cells. Previously, we had described the DNA methylation…”
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Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection by Sohail, Aaqib, Iqbal, Azeem A, Sahini, Nishika, Chen, Fangfang, Tantawy, Mohamed, Waqas, Syed F H, Winterhoff, Moritz, Ebensen, Thomas, Schultz, Kristin, Geffers, Robert, Schughart, Klaus, Preusse, Matthias, Shehata, Mahmoud, Bähre, Heike, Pils, Marina C, Guzman, Carlos A, Mostafa, Ahmed, Pleschka, Stephan, Falk, Christine, Michelucci, Alessandro, Pessler, Frank

“…Excessive inflammation is a major cause of morbidity and mortality in many viral infections including influenza. Therefore, there is a need for therapeutic…”
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Distinct Microbial Communities Trigger Colitis Development upon Intestinal Barrier Damage via Innate or Adaptive Immune Cells by Roy, Urmi, Gálvez, Eric J.C., Iljazovic, Aida, Lesker, Till Robin, Błażejewski, Adrian J., Pils, Marina C., Heise, Ulrike, Huber, Samuel, Flavell, Richard A., Strowig, Till

“…Inflammatory bowel disease comprises a group of heterogeneous diseases characterized by chronic and relapsing mucosal inflammation. Alterations in microbiota…”
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Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge by Zheng, Xiaoyan, Oduro, Jennifer D, Boehme, Julia D, Borkner, Lisa, Ebensen, Thomas, Heise, Ulrike, Gereke, Marcus, Pils, Marina C, Krmpotic, Astrid, Guzmán, Carlos A, Bruder, Dunja, Čičin-Šain, Luka

“…Cytomegalovirus (CMV) is a ubiquitous β-herpesvirus that establishes life-long latent infection in a high percentage of the population worldwide. CMV induces…”
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Microbiota Normalization Reveals that Canonical Caspase-1 Activation Exacerbates Chemically Induced Intestinal Inflammation by Błażejewski, Adrian J., Thiemann, Sophie, Schenk, Alexander, Pils, Marina C., Gálvez, Eric J.C., Roy, Urmi, Heise, Ulrike, de Zoete, Marcel R., Flavell, Richard A., Strowig, Till

“…Inflammasomes play a central role in regulating intestinal barrier function and immunity during steady state and disease. Because the discoveries of a…”
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The cytotoxic necrotizing factor of Yersinia pseudotuberculosis (CNFY) enhances inflammation and Yop delivery during infection by activation of Rho GTPases by Schweer, Janina, Kulkarni, Devesha, Kochut, Annika, Pezoldt, Joern, Pisano, Fabio, Pils, Marina C, Genth, Harald, Huehn, Jochen, Dersch, Petra

“…Some isolates of Yersinia pseudotuberculosis produce the cytotoxic necrotizing factor (CNFY), but the functional consequences of this toxin for host-pathogen…”
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Correction: Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection by Sohail, Aaqib, Iqbal, Azeem A, Sahini, Nishika, Chen, Fangfang, Tantawy, Mohamed, Waqas, Syed F H, Winterhoff, Moritz, Ebensen, Thomas, Schultz, Kristin, Geffers, Robert, Schughart, Klaus, Preusse, Matthias, Shehata, Mahmoud, Bähre, Heike, Pils, Marina C, Guzman, Carlos A, Mostafa, Ahmed, Pleschka, Stephan, Falk, Christine, Michelucci, Alessandro, Pessler, Frank

“…[This corrects the article DOI: 10.1371/journal.ppat.1010219.]…”
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An Interferon Signature Discriminates Pneumococcal From Staphylococcal Pneumonia by Strehlitz, Anja, Goldmann, Oliver, Pils, Marina C, Pessler, Frank, Medina, Eva

“…is the most common cause of community-acquired pneumonia (CAP). Despite the low prevalence of CAP caused by methicillin-resistant (MRSA), CAP patients often…”
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TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection by Metzdorf, Kristin, Jacobsen, Henning, Greweling-Pils, Marina C, Hoffmann, Markus, Lüddecke, Tatjana, Miller, Felicitas, Melcher, Lars, Kempf, Amy M, Nehlmeier, Inga, Bruder, Dunja, Widera, Marek, Ciesek, Sandra, Pöhlmann, Stefan, Čičin-Šain, Luka

“…The COVID-19 pandemic remains a global health threat and novel antiviral strategies are urgently needed. SARS-CoV-2 employs the cellular serine protease…”
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A Central Role for Atg5 in Microbiota-Dependent Foxp3 + RORγt + Treg Cell Preservation to Maintain Intestinal Immune Homeostasis by Plaza-Sirvent, Carlos, Zhao, Bei, Bronietzki, Alisha W, Pils, Marina C, Tafrishi, Neda, Schuster, Marc, Strowig, Till, Schmitz, Ingo

“…Autophagy is an evolutionary conserved catabolic pathway that ensures the degradation of intracellular components. The autophagic pathway is regulated by…”
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Improved Functionality of Exhausted Intrahepatic CXCR5+ CD8+ T Cells Contributes to Chronic Antigen Clearance Upon Immunomodulation by Kumashie, Kingsley Gideon, Cebula, Marcin, Hagedorn, Claudia, Kreppel, Florian, Pils, Marina C, Koch-Nolte, Friedrich, Rissiek, Björn, Wirth, Dagmar

“…Chronic hepatotropic viral infections are characterized by exhausted CD8+ T cells in the presence of cognate antigen in the liver. The impairment of T cell…”
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Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model by Pils, Marina C, Pisano, Fabio, Fasnacht, Nicolas, Heinrich, Jan-Michael, Groebe, Lothar, Schippers, Angela, Rozell, Björn, Jack, Robert S, Müller, Werner

“…IL-10 is a potent regulator of the innate and adaptive immune responses. Several cell types produce IL-10 and its receptor chains and these may regulate…”
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Comparative evaluation of establishing a human gut microbial community within rodent models by Wos-Oxley, Melissa L., Bleich, André, Oxley, Andrew P.A., Kahl, Silke, Janus, Lydia M., Smoczek, Anna, Nahrstedt, Hannes, Pils, Marina C., Taudien, Stefan, Platzer, Matthias, Hedrich, Hans-Jürgen, Medina, Eva, Pieper, Dietmar H.

“…The structure of the human gut microbial community is determined by host genetics and environmental factors, where alterations in its structure have been…”
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Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice by Avalos, Ana M, Kirak, Oktay, Oelkers, J Margit, Pils, Marina C, Kim, You-Me, Ottinger, Matthias, Jaenisch, Rudolf, Ploegh, Hidde L, Brinkmann, Melanie M

“…Recognition of nucleic acids by TLR9 requires its trafficking from the endoplasmic reticulum to endolysosomal compartments and its subsequent proteolytic…”
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An inducible transgenic mouse model for immune mediated hepatitis showing clearance of antigen expressing hepatocytes by CD8+ T cells by Cebula, Marcin, Ochel, Aaron, Hillebrand, Upneet, Pils, Marina C, Schirmbeck, Reinhold, Hauser, Hansjörg, Wirth, Dagmar

“…The liver has the ability to prime immune responses against neo antigens provided upon infections. However, T cell immunity in liver is uniquely modulated by…”
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Early Lymphocyte Loss and Increased Granulocyte/Lymphocyte Ratio Predict Systemic Spread of Streptococcus pyogenes in a Mouse Model of Acute Skin Infection by Loof, Torsten G, Sohail, Aaqib, Bahgat, Mahmoud M, Tallam, Aravind, Arshad, Haroon, Akmatov, Manas K, Pils, Marina C, Heise, Ulrike, Beineke, Andreas, Pessler, Frank

“…Group A streptococci may induce lymphopenia, but the value of lymphocyte loss as early biomarkers for systemic spread and severe infection has not been…”
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Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota by Koeninger, Louis, Osbelt, Lisa, Berscheid, Anne, Wendler, Judith, Berger, Jürgen, Hipp, Katharina, Lesker, Till R., Pils, Marina C., Malek, Nisar P., Jensen, Benjamin A. H., Brötz-Oesterhelt, Heike, Strowig, Till, Jan Wehkamp

“…The occurrence and spread of multidrug-resistant pathogens, especially bacteria from the ESKAPE panel, increases the risk to succumb to untreatable infections…”
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