Management of cutaneous squamous cell carcinoma in patients with epidermolysis bullosa: best clinical practice guidelines

Summary This article summarizes recommendations reached following a systematic literature review and expert consensus on the diagnosis and management of cutaneous squamous cell carcinomas in people with epidermolysis bullosa. The guidelines are intended to help inform decision making by clinicians d...

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Bibliographic Details
Published in:	British journal of dermatology (1951) Vol. 174; no. 1; pp. 56 - 67
Main Authors:	Mellerio, J.E., Robertson, S.J., Bernardis, C., Diem, A., Fine, J.D., George, R., Goldberg, D., Halmos, G.B., Harries, M., Jonkman, M.F., Lucky, A., Martinez, A.E., Maubec, E., Morris, S., Murrell, D.F., Palisson, F., Pillay, E.I., Robson, A., Salas-Alanis, J.C., McGrath, J.A.
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01-01-2016 Oxford University Press
Subjects:	Amputation - methods Artificial Limbs Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - prevention & control Carcinoma, Squamous Cell - therapy Clinical decision making Clinical practice guidelines Consensus Decision making Epidermolysis bullosa Epidermolysis Bullosa - complications Humans Literature reviews Lymphatic Metastasis Minimally Invasive Surgical Procedures - methods Neoplasm Metastasis Neoplasm Staging Pain - prevention & control Practice Guidelines as Topic Psychotherapy - methods Retinoids - therapeutic use Sentinel Lymph Node Biopsy - methods Skin Neoplasms - diagnosis Skin Neoplasms - prevention & control Skin Neoplasms - therapy Squamous cell carcinoma Terminal Care - methods Wound Closure Techniques
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Summary:	Summary This article summarizes recommendations reached following a systematic literature review and expert consensus on the diagnosis and management of cutaneous squamous cell carcinomas in people with epidermolysis bullosa. The guidelines are intended to help inform decision making by clinicians dealing with this complex complication of a devastating disease. What's already known about this topic? Some subtypes of epidermolysis bullosa (EB), particularly severe generalized recessive dystrophic EB, are associated with the development of mucocutaneous squamous cell carcinomas (SCCs). These tumours behave aggressively and are a leading cause of morbidity and mortality in at‐risk patients with EB. What does this study add? These guidelines will assist clinicians in the diagnosis, management and staging of EB‐associated cutaneous SCCs based on available evidence and expert consensus. They highlight the importance of a holistic multidisciplinary approach to the management of EB‐associated SCCs, where patient involvement in decision making is paramount. Linked Comment: Krupiczojc and O’Toole. Br J Dermatol 2016; 174: 15.
Bibliography:	ark:/67375/WNG-T3CV5JRN-8 ArticleID:BJD14104 istex:396071C4C1C6E36F003B4E099C6C1393167728C0 SourceType-Scholarly Journals-1 ObjectType-Feature-4 ObjectType-Undefined-1 content type line 23 ObjectType-Review-2 ObjectType-Article-3
ISSN:	0007-0963 1365-2133
DOI:	10.1111/bjd.14104