Search Results - "Pilkington, Guy R."

Pat1 Contains Distinct Functional Domains That Promote P-Body Assembly and Activation of Decapping by Pilkington, Guy R., Parker, Roy

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Kaposi's Sarcoma-Associated Herpesvirus ORF57 Interacts with Cellular RNA Export Cofactors RBM15 and OTT3 To Promote Expression of Viral ORF59 by MAJERCIAK, Vladimir, URANISHI, Hiroaki, KRUHLAK, Michael, PILKINGTON, Guy R, JULIA MASSIMELLI, Maria, BEAR, Jenifer, PAVLAKIS, George N, FELBER, Barbara K, ZHENG, Zhi-Ming

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Kaposi's Sarcoma-Associated Herpesvirus ORF57 Is Not a Bona Fide Export Factor by PILKINGTON, Guy R, MAJERCIAK, Vladimir, BEAR, Jenifer, URANISHI, Hiroaki, ZHENG, Zhi-Ming, FELBER, Barbara K

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The RNA Transport Element of the Murine musD Retrotransposon Requires Long-range Intramolecular Interactions for Function by Legiewicz, Michal, Zolotukhin, Andrei S., Pilkington, Guy R., Purzycka, Katarzyna J., Mitchell, Michelle, Uranishi, Hiroaki, Bear, Jenifer, Pavlakis, George N., Le Grice, Stuart F.J., Felber, Barbara K.

“…Retrovirus replication requires specialized transport mechanisms to export genomic mRNA from the nucleus to the cytoplasm of the infected cell. This regulation…”
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The p40 Subunit of Interleukin (IL)-12 Promotes Stabilization and Export of the p35 Subunit by Jalah, Rashmi, Rosati, Margherita, Ganneru, Brunda, Pilkington, Guy R., Valentin, Antonio, Kulkarni, Viraj, Bergamaschi, Cristina, Chowdhury, Bhabadeb, Zhang, Gen-Mu, Beach, Rachel Kelly, Alicea, Candido, Broderick, Kate E., Sardesai, Niranjan Y., Pavlakis, George N., Felber, Barbara K.

“…IL-12 is a 70-kDa heterodimeric cytokine composed of the p35 and p40 subunits. To maximize cytokine production from plasmid DNA, molecular steps controlling…”
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Molecular mechanisms of heparin-induced modulation of human interleukin 12 bioactivity by Nguyen, Khue G., Gillam, Francis B., Hopkins, Jared J., Jayanthi, Srinivas, Gundampati, Ravi Kumar, Su, Guowei, Bear, Jenifer, Pilkington, Guy R., Jalah, Rashmi, Felber, Barbara K., Liu, Jian, Thallapuranam, Suresh Kumar, Zaharoff, David A.

“…Human interleukin-12 (hIL-12) is a heparin-binding cytokine whose activity was previously shown to be enhanced by heparin and other sulfated…”
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A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques by Mothe, Beatriz, Hu, Xintao, Llano, Anuska, Rosati, Margherita, Olvera, Alex, Kulkarni, Viraj, Valentin, Antonio, Alicea, Candido, Pilkington, Guy R, Sardesai, Niranjan Y, Rocafort, Muntsa, Crespo, Manel, Carrillo, Jorge, Marco, Andrés, Mullins, James I, Dorrell, Lucy, Hanke, Tomáš, Clotet, Bonaventura, Pavlakis, George N, Felber, Barbara K, Brander, Christian

“…None of the HIV T-cell vaccine candidates that have reached advanced clinical testing have been able to induce protective T cell immunity. A major reason for…”
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The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 cytokine production by Jalah, Rashmi, Rosati, Margherita, Ganneru, Brunda, Pilkington, Guy R, Valentin, Antonio, Kulkarni, Viraj, Bergamaschi, Cristina, Chowdhury, Bhabadeb, Zhang, Gen-Mu, Beach, Rachel Kelly, Alicea, Candido, Broderick, Kate E, Sardesai, Niranjan Y, Pavlakis, George N, Felber, Barbara K

“…IL-12 is a 70-kDa heterodimeric cytokine composed of the p35 and p40 subunits. To maximize cytokine production from plasmid DNA, molecular steps controlling…”
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Gammaretrovirus mRNA expression is mediated by a novel, bipartite post-transcriptional regulatory element by Pilkington, Guy R, Purzycka, Katarzyna J, Bear, Jenifer, Le Grice, Stuart F J, Felber, Barbara K

“…Post-transcriptional regulatory mechanisms of several complex and simple retroviruses and retroelements have been elucidated, with the exception of the…”
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Comparative analysis of SIV-specific cellular immune responses induced by different vaccine platforms in rhesus macaques by Valentin, Antonio, McKinnon, Katherine, Li, Jinyao, Rosati, Margherita, Kulkarni, Viraj, Pilkington, Guy R, Bear, Jenifer, Alicea, Candido, Vargas-Inchaustegui, Diego A, Jean Patterson, L, Pegu, Poonam, Liyanage, Namal P.M, Gordon, Shari N, Vaccari, Monica, Wang, Yichuan, Hogg, Alison E, Frey, Blake, Sui, Yongjun, Reed, Steven G, Sardesai, Niranjan Y, Berzofsky, Jay A, Franchini, Genoveffa, Robert-Guroff, Marjorie, Felber, Barbara K, Pavlakis, George N

“…Abstract To identify the most promising vaccine candidates for combinatorial strategies, we compared five SIV vaccine platforms including recombinant canary…”
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Humoral immunity induced by mucosal and/or systemic SIV-specific vaccine platforms suggests novel combinatorial approaches for enhancing responses by Vargas-Inchaustegui, Diego A, Tuero, Iskra, Mohanram, Venkatramanan, Musich, Thomas, Pegu, Poonam, Valentin, Antonio, Sui, Yongjun, Rosati, Margherita, Bear, Jenifer, Venzon, David J, Kulkarni, Viraj, Alicea, Candido, Pilkington, Guy R, Liyanage, Namal P.M, Demberg, Thorsten, Gordon, Shari N, Wang, Yichuan, Hogg, Alison E, Frey, Blake, Patterson, L. Jean, DiPasquale, Janet, Montefiori, David C, Sardesai, Niranjan Y, Reed, Steven G, Berzofsky, Jay A, Franchini, Genoveffa, Felber, Barbara K, Pavlakis, George N, Robert-Guroff, Marjorie

“…Abstract Combinatorial HIV/SIV vaccine approaches targeting multiple arms of the immune system might improve protective efficacy. We compared SIV-specific…”
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Comparison of intradermal and intramuscular delivery followed by in vivo electroporation of SIV Env DNA in macaques by Kulkarni, Viraj, Rosati, Margherita, Bear, Jenifer, Pilkington, Guy R, Jalah, Rashmi, Bergamaschi, Cristina, Singh, Ashish K, Alicea, Candido, Chowdhury, Bhabadeb, Zhang, Gen-Mu, Kim, Eun-Young, Wolinsky, Steven M, Huang, Wensheng, Guan, Yongjun, LaBranche, Celia, Montefiori, David C, Broderick, Kate E, Sardesai, Niranjan Y, Valentin, Antonio, Felber, Barbara K, Pavlakis, George N

“…A panel of SIVmac251 transmitted Env sequences were tested for expression, function and immunogenicity in mice and macaques. The immunogenicity of a DNA…”
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The "complex" RNA post-transcriptional element of a "simple" retrovirus by Purzycka, Katarzyna J, Pilkington, Guy R, Felber, Barbara K, Le Grice, Stuart F J

“…Replication of retroviruses and transposition of endogenous retroelements exploits a unique mechanism of post-transcriptional regulation as a means of…”
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Humoral immunity induced by mucosal and/or systemic SIV-specific vaccine platforms suggest novel combinatorial approaches for enhancing responses by Vargas-Inchaustegui, Diego A., Tuero, Iskra, Mohanram, Venkatramanan, Musich, Thomas, Pegu, Poonam, Valentin, Antonio, Sui, Yongjun, Rosati, Margherita, Bear, Jenifer, Venzon, David J., Kulkarni, Viraj, Alicea, Candido, Pilkington, Guy R., Liyanage, Namal P.M., Demberg, Thorsten, Gordon, Shari N., Wang, Yichuan, Hogg, Alison E., Frey, Blake, Patterson, L. Jean, DiPasquale, Janet, Montefiori, David C., Sardesai, Niranjan Y., Reed, Steven G., Berzofsky, Jay A., Franchini, Genoveffa, Felber, Barbara K., Pavlakis, George N., Robert-Guroff, Marjorie

“…Combinatorial HIV/SIV vaccine approaches targeting multiple arms of the immune system might improve protective efficacy. We compared SIV-specific humoral…”
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