Search Results - "Piligian, Brent"
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Benralizumab for PDGFRA-Negative Hypereosinophilic Syndrome
Published in The New England journal of medicine (04-04-2019)“…Benralizumab, an interleukin-5 receptor blocker, significantly reduced absolute eosinophil counts and relieved symptoms in a small group of patients with…”
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Photoactivatable Glycolipid Probes for Identifying Mycolate–Protein Interactions in Live Mycobacteria
Published in Journal of the American Chemical Society (29-04-2020)“…Mycobacteria have a distinctive glycolipid-rich outer membrane, the mycomembrane, which is a critical target for tuberculosis drug development. However,…”
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The trehalose-specific transporter LpqY-SugABC is required for antimicrobial and anti-biofilm activity of trehalose analogues in Mycobacterium smegmatis
Published in Carbohydrate research (10-10-2017)“…Mycobacteria, including the bacterial pathogen that causes human tuberculosis, possess distinctive pathways for synthesizing and utilizing the non-mammalian…”
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A trifunctional cyclooctyne for modifying azide-labeled biomolecules with photocrosslinking and affinity tags
Published in Chemical communications (Cambridge, England) (25-12-2015)“…A bicyclo[6.1.0]nonyne (BCN)-based cyclooctyne reagent bearing a photocrosslinking diazirine (DAz) group and a biotin affinity handle, BCN-DAz-Biotin, is…”
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Benralizumab for PDGFRA -Negative Hypereosinophilic Syndrome
Published in The New England journal of medicine (04-04-2019)Get full text
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A FRET-Based Fluorogenic Trehalose Dimycolate Analogue for Probing Mycomembrane-Remodeling Enzymes of Mycobacteria
Published in ACS omega (28-02-2019)“…The mycobacterial outer membrane, or mycomembrane, is essential for the viability and virulence of Mycobacterium tuberculosis and related pathogens. The…”
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Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues
Published in Journal of visualized experiments (17-02-2017)“…Chemically modified versions of trehalose, or trehalose analogues, have applications in biology, biotechnology, and pharmaceutical science, among other fields…”
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Single-Organ and Multisystem Hypereosinophilic Syndrome Patients with Gastrointestinal Manifestations Share Common Characteristics
Published in The journal of allergy and clinical immunology in practice (Cambridge, MA) (01-09-2020)“…Eosinophilic gastrointestinal diseases (EGIDs) are defined by marked eosinophilia in the gastrointestinal (GI) tract resulting in a wide variety of GI…”
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Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues
Published in Journal of visualized experiments (17-02-2017)Get full text
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