Biomimetic hydroxyapatite used in the treatment of periodontal intrabony pockets: clinical and radiological analysis

Biomimetic hydroxyapatite used in the treatment of periodontal intrabony pockets: clinical and radiological analysis

Hydroxyapatite (PA) has a chemical composition and physical structure very similar to natural bone and therefore it has been considered to be the ideal biomaterial able to ensure a biomimetic scaffold to use in bone tissue engineering. The aim of this study is to clinically test hydroxyapatite used...

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Bibliographic Details
Published in:Annali di stomatologia Vol. 7; no. 1-2; p. 16
Main Authors: Figliuzzi, Michele Mario, Giudice, Amerigo, Pileggi, Settimia, Scordamaglia, Francesco, Marrelli, Massimo, Tatullo, Marco, Fortunato, Leonzio
Format: Journal Article
Language:English
Published: Italy CIC Edizioni Internazionali 01-01-2016
CIC Edizioni Internationali
Subjects:
Biomaterials
Biomedical materials
Biomimetics
Bones
Cell adhesion & migration
Defects
Hydroxyapatite
Maxillofacial surgery
Oral diseases
Original
Patients
Statistical analysis
Studies
Surgical implants
hydroxyapatite
radiological
clinical
intrabony pockets
biomimetic
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Summary:Hydroxyapatite (PA) has a chemical composition and physical structure very similar to natural bone and therefore it has been considered to be the ideal biomaterial able to ensure a biomimetic scaffold to use in bone tissue engineering. The aim of this study is to clinically test hydroxyapatite used as osteoconductive biomaterial in the treatment of periodontal bone defects. Clinical and radiological evaluations were conducted at 6, 12 and 18 months after the surgery. Forty patients with 2- and 3-wall intrabony pockets were enrolled in this study. PPD, CAL, radiographic depth (RD) and angular defects were preoperatively measured. After surgery, patients were re-evaluated every 6 months for 18 months. Statistical analyses were also performed to investigate any differences between preoperative and postoperative measurements. Paired t-test samples conducted on the data obtained at baseline and 18 months after, showed significant (p<0.01) differences in each measurement performed. The role of preoperative RD was demonstrated to be a significant key factor (p<0.01). A relevant correlation between preoperative PPD and CAL gain was also found. Within the limitations of this study, the absence of anatomical variables, except the morphology of the bone defect, emphasizes the importance of the proper surgical approach and the graft material used.
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These Authors contributed equally to this article.
ISSN:1824-0852
1971-1441
1971-1441
DOI:10.11138/ads/2016.7.1.016