Search Results - "Pilch, Zofia"

Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma by Czystowska-Kuzmicz, Malgorzata, Sosnowska, Anna, Nowis, Dominika, Ramji, Kavita, Szajnik, Marta, Chlebowska-Tuz, Justyna, Wolinska, Ewa, Gaj, Pawel, Grazul, Magdalena, Pilch, Zofia, Zerrouqi, Abdessamad, Graczyk-Jarzynka, Agnieszka, Soroczynska, Karolina, Cierniak, Szczepan, Koktysz, Robert, Elishaev, Esther, Gruca, Slawomir, Stefanowicz, Artur, Blaszczyk, Roman, Borek, Bartlomiej, Gzik, Anna, Whiteside, Theresa, Golab, Jakub

“…Tumor-driven immune suppression is a major barrier to successful immunotherapy in ovarian carcinomas (OvCa). Among various mechanisms responsible for immune…”
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Inhibition of arginase modulates T-cell response in the tumor microenvironment of lung carcinoma by Sosnowska, Anna, Chlebowska-Tuz, Justyna, Matryba, Pawel, Pilch, Zofia, Greig, Alan, Wolny, Artur, Grzywa, Tomasz M., Rydzynska, Zuzanna, Sokolowska, Olga, Rygiel, Tomasz P., Grzybowski, Marcin, Stanczak, Paulina, Blaszczyk, Roman, Nowis, Dominika, Golab, Jakub

“…Immunotherapy has demonstrated significant activity in a broad range of cancer types, but still the majority of patients receiving it do not maintain durable…”
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The CD200 Regulates Inflammation in Mice Independently of TNF-α Production by Tonecka, Katarzyna, Braniewska, Agata, Pilch, Zofia, Sas, Zuzanna, Skorzynski, Marcin, Manuali, Elisabetta, Rygiel, Tomasz P.

“…Inflammatory bowel disease is characterized by the infiltration of immune cells and chronic inflammation. The immune inhibitory receptor, CD200R, is involved…”
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The pro-tumor effect of CD200 expression is not mimicked by agonistic CD200R antibodies by Pilch, Zofia, Tonecka, Katarzyna, Skorzynski, Marcin, Sas, Zuzanna, Braniewska, Agata, Kryczka, Tomasz, Boon, Louis, Golab, Jakub, Meyaard, Linde, Rygiel, Tomasz P

“…Tumor-infiltrating immune cells can impact tumor growth and progression. The inhibitory CD200 receptor (CD200R) suppresses the activation of myeloid cells and…”
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Targeting arginase-1 exerts antitumor effects in multiple myeloma and mitigates bortezomib-induced cardiotoxicity by Ramji, Kavita, Grzywa, Tomasz M., Sosnowska, Anna, Paterek, Aleksandra, Okninska, Marta, Pilch, Zofia, Barankiewicz, Joanna, Garbicz, Filip, Borg, Katarzyna, Bany-Laszewicz, Urszula, Zerrouqi, Abdesamad, Pyrzynska, Beata, Rodziewicz-Lurzynska, Anna, Papiernik, Diana, Sklepkiewicz, Piotr, Kedzierska, Hanna, Staruch, Adam, Sadowski, Radoslaw, Ciepiela, Olga, Lech-Maranda, Ewa, Juszczynski, Przemyslaw, Mackiewicz, Urszula, Maczewski, Michal, Nowis, Dominika, Golab, Jakub

“…Multiple myeloma (MM) remains an incurable malignancy of plasma cells despite constantly evolving therapeutic approaches including various types of…”
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Immune checkpoint inhibition improves antimyeloma activity of bortezomib and STING agonist combination in VkMYC preclinical model by Sokolowska, Olga, Rodziewicz-Lurzynska, Anna, Pilch, Zofia, Kedzierska, Hanna, Chlebowska-Tuz, Justyna, Sosnowska, Anna, Szumera-Cieckiewicz, Anna, Sokol, Kamil, Barankiewicz, Joanna, Salomon-Perzynski, Aleksander, Ciepiela, Olga, Lech-Maranda, Ewa, Golab, Jakub, Nowis, Dominika

“…Multiple myeloma (MM), a hematological malignancy of plasma cells, has remained incurable despite the development of novel therapies that improve patients’…”
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PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells by Bajor, Malgorzata, Graczyk-Jarzynka, Agnieszka, Marhelava, Katsiaryna, Burdzinska, Anna, Muchowicz, Angelika, Goral, Agnieszka, Zhylko, Andriy, Soroczynska, Karolina, Retecki, Kuba, Krawczyk, Marta, Klopotowska, Marta, Pilch, Zofia, Paczek, Leszek, Malmberg, Karl-Johan, Wälchli, Sébastien, Winiarska, Magdalena, Zagozdzon, Radoslaw

“…BackgroundImmune checkpoint inhibitors and chimeric antigen receptor (CAR)-based therapies have transformed cancer treatment. Recently, combining these…”
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Antitumor Activity of TLR7 Is Potentiated by CD200R Antibody Leading to Changes in the Tumor Microenvironment by Pilch, Zofia, Tonecka, Katarzyna, Braniewska, Agata, Sas, Zuzanna, Skorzynski, Marcin, Boon, Louis, Golab, Jakub, Meyaard, Linde, Rygiel, Tomasz P

“…Stimulation of Toll-like receptor 7 (TLR7) activates myeloid cells and boosts the immune response. Previously, we have shown that stimulation of the inhibitory…”
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Inhibition of protein disulfide isomerase induces differentiation of acute myeloid leukemia cells by Chlebowska-Tuz, Justyna, Sokolowska, Olga, Gaj, Pawel, Lazniewski, Michal, Firczuk, Malgorzata, Borowiec, Karolina, Sas-Nowosielska, Hanna, Bajor, Malgorzata, Malinowska, Agata, Muchowicz, Angelika, Ramji, Kavita, Stawinski, Piotr, Sobczak, Mateusz, Pilch, Zofia, Rodziewicz-Lurzynska, Anna, Zajac, Malgorzata, Giannopoulos, Krzysztof, Juszczynski, Przemyslaw, Basak, Grzegorz W, Plewczynski, Dariusz, Ploski, Rafal, Golab, Jakub, Nowis, Dominika

“…A cute myeloid leukemia is a malignant disease of immature myeloid cells. Despite significant therapeutic effects of differentiation-inducing agents in some…”
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Immune Cells in Cancer Therapy and Drug Delivery by Król, Magdalena, Rygiel, Tomasz P., Boffi, Alberto, Ulewicz, Katarzyna, Taciak, Bartlomiej, Mucha, Joanna, Tonecka, Katarzyna, Pilch, Zofia, Majchrzak, Kinga, Eyileten, Ceren, Witt, Katarzyna

“…Recent studies indicate the critical role of tumour associated macrophages, tumour associated neutrophils, dendritic cells, T lymphocytes, and natural killer…”
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Targeting Negative and Positive Immune Checkpoints with Monoclonal Antibodies in Therapy of Cancer by Marhelava, Katsiaryna, Pilch, Zofia, Bajor, Malgorzata, Graczyk-Jarzynka, Agnieszka, Zagozdzon, Radoslaw

“…The immune checkpoints are regulatory molecules that maintain immune homeostasis in physiological conditions. By sending T cells a series of co-stimulatory or…”
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Inhibition of lymphangiogenesis impairs antitumour effects of photodynamic therapy and checkpoint inhibitors in mice by Muchowicz, Angelika, Wachowska, Malgorzata, Stachura, Joanna, Tonecka, Katarzyna, Gabrysiak, Magdalena, Wołosz, Dominika, Pilch, Zofia, Kilarski, Witold W., Boon, Louis, Klaus, Tomasz J., Golab, Jakub

“…Photodynamic therapy (PDT) has been shown to destroy tumour-associated lymphatic vessels. Therefore, we sought to investigate the functional outcomes of…”
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Dasatinib Effect on NK Cells and Anti-Tumor Immunity by Lachota, Mieszko, Siernicka, Marta, Pilch, Zofia, Graczyk-Jarzynka, Agnieszka, Winiarska, Magdalena

“…Introduction Dasatinib is a potent small molecule kinase inhibitor targeting BCR-ABL kinase - oncogenic driver in Philadelphia chromosome-positive (Ph+) cases…”
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Immunoregulatory CD71+ Erythroid Cells (CECs) Expand in Multiple Myeloma and Impair Control of L. Monocytogenes Infection by Grzywa, Tomasz M., Czubak, Karol, Sidor, Karolina, Pilch, Zofia, Bragiel-Pieczonka, Aneta, Hoser, Grazyna, Rodziewicz-Lurzynska, Anna, Małecka-Giełdowska, Milena, Barankiewicz, Joanna, Garbicz, Filip, Ciepiela, Olga, Juszczynski, Przemyslaw, Wegrzynowicz, Michal, Skirecki, Tomasz, Golab, Jakub, Nowis, Dominika

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PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress by Klopotowska, Marta, Bajor, Malgorzata, Graczyk-Jarzynka, Agnieszka, Kraft, Agnieszka, Pilch, Zofia, Zhylko, Andriy, Firczuk, Malgorzata, Baranowska, Iwona, Lazniewski, Michal, Plewczynski, Dariusz, Goral, Agnieszka, Soroczynska, Karolina, Domagala, Joanna, Marhelava, Katsiaryna, Slusarczyk, Aleksander, Retecki, Kuba, Ramji, Kavita, Krawczyk, Marta, Temples, Madison N, Sharma, Blanka, Lachota, Mieszko, Netskar, Herman, Malmberg, Karl-Johan, Zagozdzon, Radoslaw, Winiarska, Magdalena

“…Oxidative stress, caused by the imbalance between reactive species generation and the dysfunctional capacity of antioxidant defenses, is one of the…”
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Super-Enhancer-Driven PIM Kinase Upregulation in Multiple Myeloma Maintains the Plasma Cell-Specific Oncogenic and Microenvironmental Circuits, and Can be Efficiently Targeted By the Pan-PIM Inhibitor MEN1703 by Garbicz, Filip, Debek, Sonia, Szumera-Ciećkiewicz, Anna, Barankiewicz, Joanna, Komar, Dorota, Pawlak, Michał, Matrejek, Aleksandra, Stuehmer, Thorsten, Salomon-Perzynski, Aleksander, Malenda, Agata, Ostrowska, Julia, Dudkiewicz, Julia, Brzózka, Krzysztof, Rzymski, Tomasz, Bellarosa, Daniela, Lech-Marańda, Ewa, Prochorec-Sobieszek, Monika, Pilch, Zofia, Nowis, Dominika, Golab, Jakub, Tanton, Helen, Hideshima, Teru, Dorfman, David M., Misiewicz-Krzeminska, Irena, Sewastianik, Tomasz, Carrasco, Ruben D., Szydlowski, Maciej, Juszczynski, Przemyslaw

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Arginase Inhibition Mitigates Bortezomib-Exacerbated Cardiotoxicity in Multiple Myeloma by Paterek, Aleksandra, Oknińska, Marta, Pilch, Zofia, Sosnowska, Anna, Ramji, Kavita, Mackiewicz, Urszula, Golab, Jakub, Nowis, Dominika, Mączewski, Michał

“…Multiple myeloma (MM) is associated with increased cardiovascular morbidity and mortality, while MM therapies also result in adverse cardiac effects…”
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SK053 triggers tumor cells apoptosis by oxidative stress-mediated endoplasmic reticulum stress by Muchowicz, Angelika, Firczuk, Małgorzata, Wachowska, Małgorzata, Kujawa, Marek, Jankowska-Steifer, Ewa, Gabrysiak, Magdalena, Pilch, Zofia, Kłossowski, Szymon, Ostaszewski, Ryszard, Golab, Jakub

“…Thioredoxins (Trx) together with thioredoxin reductases (TrxR) participate in the maintenance of protein thiol homeostasis and play cytoprotective roles in…”
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Low dose of GRP78-targeting subtilase cytotoxin improves the efficacy of photodynamic therapy in vivo by GABRYSIAK, MAGDALENA, WACHOWSKA, MALGORZATA, BARANKIEWICZ, JOANNA, PILCH, ZOFIA, RATAJSKA, ANNA, SKRZYPEK, EWA, WINIARSKA, MAGDALENA, DOMAGALA, ANTONI, RYGIEL, TOMASZ P, JOZKOWICZ, ALICJA, BOON, LOUIS, GOLAB, JAKUB, FIRCZUK, MALGORZATA

“…Photodynamic therapy (PDT) exerts direct cytotoxic effects on tumor cells, destroys tumor blood and lymphatic vessels and induces local inflammation. Although…”
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Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies by Winiarska, Magdalena, Bojarczuk, Kamil, Pyrzynska, Beata, Bil, Jacek, Siernicka, Marta, Dwojak, Michal, Bobrowicz, Malgorzata, Miazek, Nina, Zapala, Piotr, Zagozdzon, Agnieszka, Krol, Magdalena, Syta, Aleksandra, Podszywalow-Bartnicka, Paulina, Pilch, Zofia, Dabrowska-Iwanicka, Anna, Juszczynski, Przemyslaw, Efremov, Dimitar G, Slabicki, Mikolaj, Zenz, Thorsten, Le Roy, Aude, Olive, Daniel, Rygiel, Tomasz P, Leusen, Jeanette H W, Golab, Jakub

“…Clinical trials with SRC family kinases (SFKs) inhibitors used alone or in a combination with anti-CD20 monoclonal antibodies (mAbs) are currently underway in…”
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