Search Results - "Pilch, D S"

A Structural Model for the Ternary Cleavable Complex Formed between Human Topoisomerase I, DNA, and Camptothecin by Kerrigan, John E, Pilch, Daniel S

“…Using the X-ray crystal structure of the human topoisomerase I (TOP1)−DNA cleavable complex, we have developed a general model for the ternary drug−DNA−TOP1…”
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Influence of Cisplatin Intrastrand Crosslinking on the Conformation, Thermal Stability, and Energetics of a 20-mer DNA Duplex by Poklar, Natas̆a, Pilch, Daniel S., Lippard, Stephen J., Redding, Elizabeth A., Dunham, Shari U., Breslauer, Kenneth J.

“…cis-Diamminedichloroplatinum(II) (cisplatin) is a widely used anticancer drug that binds to and crosslinks DNA. The major DNA adduct of the drug results from…”
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Binding of a Hairpin Polyamide in the Minor Groove of DNA: Sequence-Specific Enthalpic Discrimination by Pilch, Daniel S., Poklar, Nataša, Gelfand, Craig A., Law, Scott M., Breslauer, Kenneth J., Baird, Eldon E., Dervan, Peter B.

“…Hairpin polyamides are synthetic ligands for sequence-specific recognition in the minor groove of double-helical DNA. A thermodynamic characterization of the…”
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Structural analysis of the (dA)10.2(dT)10 triple helix by Pilch, D S, Levenson, C, Shafer, R H

“…The existence of DNA triple helices in vitro has been known for some time. Recent evidence suggesting that DNA triplexes exist in vivo and showing their…”
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Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors by SONG JIN, JUNG SUN KIM, SIM, S.-P, LIU, A, PILCH, D. S, LIU, L. F, LAVOIE, E. J

“…A series of 2'-heterocyclic derivatives of 5-phenyl-2,5'-1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. Topo I…”
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Structure, stability, and thermodynamics of a short intermolecular purine-purine-pyrimidine triple helix by Pilch, Daniel S, Levenson, Corey, Shafer, Richard H

“…We have investigated the structure and physical chemistry of the d(C3T4C3).2[d(G3A4G3)] triple helix by polyacrylamide gel electrophoresis (PAGE), 1H NMR, and…”
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Thermodynamics of triple helix formation : spectrophotometric studies on the d(A)10.2d(T)10 and d(C+3T4C+3)•d(G3A4G3)•d(C3T4C3) triple helices by PILCH, D. S, BROUSSEAU, R, SHAFER, R. H

“…We have stabilized the d(A)10.2d(T)10 and d(C+LT4C+3).d(G3A4G3).d(C3T4C3) triple helices with either NaCl or MgCl2 at pH 5.5. UV mixing curves demonstrate a…”
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Ligand-Induced Formation of Nucleic Acid Triple Helices by Pilch, Daniel S., Breslauer, Kenneth J.

“…We demonstrate that ligand binding can be used to induce the formation of triplex structures that would not otherwise form. Specifically, we show that binding…”
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Thermodynamics of Aminoglycoside−rRNA Recognition:  The Binding of Neomycin-Class Aminoglycosides to the A Site of 16S rRNA by Kaul, Malvika, Pilch, Daniel S

“…We use spectroscopic and calorimetric techniques to characterize the binding of the aminoglycoside antibiotics neomycin, paromomycin, and ribostamycin to a RNA…”
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Site-Specific Topoisomerase I-Mediated DNA Cleavage Induced by Nogalamycin:  A Potential Role of Ligand-Induced DNA Bending at a Distal Site by Sim, Sai-Peng, Pilch, Daniel S, Liu, Leroy F

“…Many DNA binding ligands (e.g., nogalamycin, actinomycin D, terbenzimidazoles, indolocarbazoles, nitidine, and coralyne) and various types of DNA lesions…”
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Defining the Basis for the Specificity of Aminoglycoside-rRNA Recognition: A Comparative Study of Drug Binding to the A Sites of Escherichia coli and Human rRNA by Kaul, Malvika, Barbieri, Christopher M., Pilch, Daniel S.

“…2-Deoxystreptamine (2-DOS) aminoglycoside antibiotics exert their antimicrobial activities by targeting the decoding region A site of the rRNA and inhibiting…”
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2-substituted 5-phenylterbenzimidazoles as topoisomerase I poisons by RANGARAJAN, M, JUNG SUN KIM, SONG JIN, SIM, S.-P, LIU, A, PILCH, D. S, LIU, L. F, LAVOIE, E. J

“…5-Phenylterbenzimidazole (1) is active as a topoisomerase I poison (topo I) and is cytotoxic to human tumor cells. No cross-resistance was observed for 1 when…”
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Thermodynamics of aminoglycoside-rRNA recognition by Pilch, Daniel S., Kaul, Malvika, Barbieri, Christopher M., Kerrigan, John E.

“…2‐Deoxystreptamine (2‐DOS) aminoglycosides are a family of structurally related broad‐spectrum antibiotics that are used widely in the treatment of infections…”
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Human Topoisomerase I Poisoning by Protoberberines:  Potential Roles for Both Drug−DNA and Drug−Enzyme Interactions by Li, Tsai-Kun, Bathory, Eleanor, LaVoie, Edmond J, Srinivasan, A. R, Olson, Wilma K, Sauers, Ronald R, Liu, Leroy F, Pilch, Daniel S

“…Protoberberines represent a structural class of organic cations that induce topoisomerase I-mediated DNA cleavage, a behavior termed topoisomerase I poisoning…”
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Aminoglycoside binding in the major groove of duplex RNA: the thermodynamic and electrostatic forces that govern recognition by Jin, Emily, Katritch, Vsevolod, Olson, Wilma K., Kharatisvili, Malkhaz, Abagyan, Ruben, Pilch, Daniel S.

“…We use a combination of spectroscopic, calorimetric, viscometric and computer modeling techniques to characterize the binding of the aminoglycoside antibiotic,…”
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Pentamidine inhibits catalytic activity of group I intron Ca.LSU by altering RNA folding by Zhang, Yi, Li, Zhijie, Pilch, Daniel S., Leibowitz, Michael J.

“…The antimicrobial agent pentamidine inhibits the self-splicing of the group I intron Ca.LSU from the transcripts of the 26S rRNA gene of Candida albicans, but…”
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Deciphering the Origins of Observed Heat Capacity Changes for Aminoglycoside Binding to Prokaryotic and Eukaryotic Ribosomal RNA A-Sites:  A Calorimetric, Computational, and Osmotic Stress Study by Barbieri, Christopher M, Srinivasan, Annankoil R, Pilch, Daniel S

“…Isothermal titration calorimetry (ITC), computational, and osmotic stress techniques have been used to characterize the changes in heat capacity,…”
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Berenil [1,3-bis(4'-amidinophenyl)triazene] binding to DNA duplexes and to a RNA duplex: evidence for both intercalative and minor groove binding properties by Pilch, D S, Kirolos, M A, Liu, X, Plum, G E, Breslauer, K J

“…Berenil is an antitrypanosomal agent that binds to nucleic acid duplexes. The generally accepted mode of berenil binding is via complexation into the minor…”
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Minor Groove-Directed and Intercalative Ligand−DNA Interactions in the Poisoning of Human DNA Topoisomerase I by Protoberberine Analogs by Pilch, Daniel S, Yu, Chiang, Makhey, Darshan, LaVoie, Edmond J, Srinivasan, A. R, Olson, Wilma K, Sauers, Ronald R, Breslauer, Kenneth J, Geacintov, Nicholas E, Liu, Leroy F

“…Spectroscopic, calorimetric, DNA cleavage, electrophoretic, and computer modeling techniques have been employed to characterize the DNA binding and…”
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DNA sequence context modulates the impact of a cisplatin 1,2-d(GpG) intrastrand cross-link on the conformational and thermodynamic properties of duplex DNA by Pilch, Daniel S, Dunham, Shari U, Jamieson, Elizabeth R, Lippard, Stephen J, Breslauer, Kenneth J

“…The anticancer activity of cisplatin derives from its ability to bind and cross-link DNA, with the major adduct being the 1,2-d(GpG) intrastrand cross-link…”
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