Search Results - "Pilatova, Martina Bago"

Targeting hematological malignancies with isoxazole derivatives by Majirská, Monika, Pilátová, Martina Bago, Kudličková, Zuzana, Vojtek, Martin, Diniz, Carmen

“…[Display omitted] •Hematological malignancies comprise 1.2 million new cases annually worldwide.•Current treatment options are limited by cancer cell…”
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Derivatives Incorporating Acridine, Pyrrole, and Thiazolidine Rings as Promising Antitumor Agents by Garberová, Monika, Potočňák, Ivan, Tvrdoňová, Monika, Majirská, Monika, Bago-Pilátová, Martina, Bekešová, Slávka, Kováč, Andrej, Takáč, Peter, Khiratkar, Krutika, Kudličková, Zuzana, Elečko, Ján, Vilková, Mária

“…Derivatives combining acridine, pyrrole, and thiazolidine rings have emerged as promising candidates in the field of antitumor drug discovery. This paper aims…”
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Ceramides and their roles in programmed cell death by Pilátová, Martina Bago, Solárová, Zuzana, Mezencev, Roman, Solár, Peter

“…Programmed cell death plays a crucial role in maintaining the homeostasis and integrity of multicellular organisms, and its dysregulation contributes to the…”
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An approach to pyrrolidine-containing sphingomimetics based on l-tartaric acid chiron by Špaková Raschmanová, Jana, Fábian, Martin, Sudzina, Adam, Martinková, Miroslava, Bago Pilátová, Martina, Cvačka, Josef, Kofroňová, Edita, Mezencev, Roman

“…A short synthetic approach to constructing pyrrolidine-containing sphingolipid-like derivatives has been accomplished. The cornerstone feature of the synthesis…”
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Straightforward access to novel cytotoxic phytosphingosine-like aminotriols from l-erythrose chiron by Vargová, Kristína, Martinková, Miroslava, Raschmanová, Jana Špaková, Pilátová, Martina Bago, Kešeľáková, Alexandra, Jáger, Dávid

“…A divergent approach to a small library of long-chain 6-amino-1,4,5-triols as novel phytosphingosine-type entities, together with their preliminary cytotoxic…”
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The first synthesis of natural alkaloid capparine A by Očenášová, Lucia, Budovská, Mariana, Očenáš, Peter, Tomášková, Nataša, Pilátová, Martina Bago, Mojžiš, Ján

“…Substances containing a spirooxindole framework display important biological activities. Natural alkaloid capparine A [(S)-(−)-1] has an anti-inflammatory…”
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Synthesis and in vitro anticancer activity of penaresidin-related stereoisomeric analogues by Raschmanová, Jana Špaková, Martinková, Miroslava, Pilátová, Martina Bago, Nosálová, Natália, Kuchár, Juraj, Bodnár, Gergo

“…A straightforward route to penaresidin-based derivatives with an unsubstituted alkyl side chain was developed. To construct these stereoisomeric…”
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Involvement of Both Extrinsic and Intrinsic Apoptotic Pathways in Tridecylpyrrolidine-Diol Derivative-Induced Apoptosis In Vitro by Nosalova, Natalia, Keselakova, Alexandra, Kello, Martin, Martinkova, Miroslava, Fabianova, Dominika, Pilatova, Martina Bago

“…Despite the decreasing trend in mortality from colorectal cancer, this disease still remains the third most common cause of death from cancer. In the present…”
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Synthesis and in vitro biological evaluation of 3-amino-3-deoxydihydrosphingosines and their analogues by Raschmanová, Jana Špaková, Martinková, Miroslava, Gonda, Jozef, Pilátová, Martina Bago, Kuchár, Juraj, Jáger, Dávid

“…The stereoselective synthesis of the 3-amino-3-deoxydihydrosphingosines and their isomeric analogues from dimethyl l-tartrate is described by means of…”
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Synthesis and in vitro cytotoxic evaluation of spiro-β-lactone-γ-lactam scaffolds by Fábian, Martin, Gonda, Jozef, Jacková, Dominika, Martinková, Miroslava, Pilátová, Martina Bago, Jáger, Dávid

“…A successful approach to the construction of spiro-β-lactone-γ-lactam synthons 5 and ent-5 as a similar structural motif present in natural products such as…”
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Synthesis and biological activity of diastereoisomeric octahydro-1H-indole-5,6,7-triols, analogues of castanospermine by Gonda, Jozef, Široký, Michael, Martinková, Miroslava, Homolya, Samuel, Vilková, Mária, Pilátová, Martina Bago, Šesták, Sergej

“…A straightforward stereoselective route towards (3aR,5R,6S,7R,7aR)- and (3aR,5R,6S,7R,7aR)-octahydro-1H-indole-5,6,7-triol, analogues of castanospermine,…”
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Stereoselective synthesis and antiproliferative activity of the isomeric sphinganine analogues by Čonková, Miroslava, Martinková, Miroslava, Gonda, Jozef, Jacková, Dominika, Pilátová, Martina Bago, Kupka, Daniel, Jáger, Dávid

“…A flexible synthetic approach to biologically active sphingoid base-like compounds with a 3-amino-1,2-diol framework was achieved through a [3,3]-sigmatropic…”
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Synthesis of the cytotoxic phytosphingosines and their isomeric analogues by Raschmanová, Jana Špaková, Martinková, Miroslava, Gonda, Jozef, Pilátová, Martina Bago, Kupka, Daniel, Jáger, Dávid

“…A straightforward synthesis of l-lyxo- and l-xylo-phytosphingosine along with their isomeric analogues has been accomplished. The salient features of this…”
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A stereoselective approach towards a small library of cytotoxic isomeric sphingoid bases by Fabišíková, Milica, Martinková, Miroslava, Gonda, Jozef, Jacková, Dominika, Bago Pilátová, Martina, Kuchár, Juraj

“…Two approaches to a small library of cytotoxic dihydrosphingosine analogues are described. [3,3]-Sigmatropic rearrangements along with an OCM reaction were…”
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Synthesis and anticancer profile of novel sphingoid base-like compounds with a quaternary stereocentre by Jacková, Dominika, Brunderová, Mária, Fábian, Martin, Martinková, Miroslava, Gonda, Jozef, Pilátová, Martina Bago

“…The synthesis of novel sphingoid base-like compounds with a quaternary stereocentre was achieved in a sequence featuring [3,3]-sigmatropic rearrangements and…”
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The convergent synthesis and anticancer activity of broussonetinines related analogues by Jacková, Dominika, Martinková, Miroslava, Gonda, Jozef, Stanková, Kvetoslava, Bago Pilátová, Martina, Herich, Peter, Kožíšek, Jozef

“…The convergent synthesis of broussonetinines related congeners 3 and 4 with the simple C13 alkyl side chain and differently configured pyrrolidine skeleton has…”
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Total synthesis and the anticancer activity of (+)-spisulosine by Fabišíková, Milica, Martinková, Miroslava, Hirková, Simona, Gonda, Jozef, Pilátová, Martina Bago, Gönciová, Gabriela

“…The total synthesis of the anticancer agent (+)-spisulosine has been accomplished. The strategy involved a substrate-controlled aza-Claisen rearrangement to…”
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Stereoselective synthesis and anticancer activity of broussonetine analogues by Jacková, Dominika, Martinková, Miroslava, Gonda, Jozef, Vilková, Mária, Pilátová, Martina Bago, Takáč, Peter

“…[Display omitted] The stereoselective synthesis of two broussonetine analogues 14·HCl and ent-14·HCl with differing stereochemistry of the polyhydroxylated…”
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Assessment of the effects of Annona muricata leaf aqueous extract in vitro by Liliána, Buzogáňová, Martin, Kello, Martina, Bago Pilátová, Ogurčáková, Daniela, Vašková, Janka

“…Background:  The extracts of Annona muricata, also known as graviola, form part of traditional medicine. Objectives: Verification of their effects and…”
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Development of novel parameter for monitoring of malignant melanoma progression by Špaková, Ivana, Rabajdová, Miroslava, Dubayová, Katarína, Nagyová, Vladimíra, Pilátová, Martina Bago, Mareková, Mária

“…Increasing HIFs in malignant melanoma, the highly aggressive skin tumour, results in the stimulation of invasiveness. Increased HIF-1α fallouts in inhibition…”
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