Search Results - "Pikor, Natalia"

Differentiation and activation of fibroblastic reticular cells by Lütge, Mechthild, Pikor, Natalia B., Ludewig, Burkhard

“…Secondary lymphoid organs (SLO) are underpinned by fibroblastic reticular cells (FRC) that form dedicated microenvironmental niches to secure induction and…”
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Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation by Pikor, Natalia B., Astarita, Jillian L., Summers-Deluca, Leslie, Galicia, Georgina, Qu, Joy, Ward, Lesley A., Armstrong, Susan, Dominguez, Claudia X., Malhotra, Deepali, Heiden, Brendan, Kay, Robert, Castanov, Valera, Touil, Hanane, Boon, Louis, O’Connor, Paul, Bar-Or, Amit, Prat, Alexandre, Ramaglia, Valeria, Ludwin, Samuel, Turley, Shannon J., Gommerman, Jennifer L.

“…Tertiary lymphoid tissues (TLTs) have been observed in the meninges of multiple sclerosis (MS) patients, but the stromal cells and molecular signals that…”
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Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp by Cheng, Hung-Wei, Onder, Lucas, Novkovic, Mario, Soneson, Charlotte, Lütge, Mechthild, Pikor, Natalia, Scandella, Elke, Robinson, Mark D., Miyazaki, Jun-ichi, Tersteegen, Anne, Sorg, Ursula, Pfeffer, Klaus, Rülicke, Thomas, Hehlgans, Thomas, Ludewig, Burkhard

“…The splenic white pulp is underpinned by poorly characterized stromal cells that demarcate distinct immune cell microenvironments. Here we establish…”
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Remodeling of light and dark zone follicular dendritic cells governs germinal center responses by Pikor, Natalia B., Mörbe, Urs, Lütge, Mechthild, Gil-Cruz, Cristina, Perez-Shibayama, Christian, Novkovic, Mario, Cheng, Hung-Wei, Nombela-Arrieta, César, Nagasawa, Takashi, Linterman, Michelle A., Onder, Lucas, Ludewig, Burkhard

“…Efficient generation of germinal center (GC) responses requires directed movement of B cells between distinct microenvironments underpinned by specialized B…”
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B cell zone reticular cell microenvironments shape CXCL13 gradient formation by Cosgrove, Jason, Novkovic, Mario, Albrecht, Stefan, Pikor, Natalia B., Zhou, Zhaoukun, Onder, Lucas, Mörbe, Urs, Cupovic, Jovana, Miller, Helen, Alden, Kieran, Thuery, Anne, O’Toole, Peter, Pinter, Rita, Jarrett, Simon, Taylor, Emily, Venetz, Daniel, Heller, Manfred, Uguccioni, Mariagrazia, Legler, Daniel F., Lacey, Charles J., Coatesworth, Andrew, Polak, Wojciech G., Cupedo, Tom, Manoury, Bénedicte, Thelen, Marcus, Stein, Jens V., Wolf, Marlene, Leake, Mark C., Timmis, Jon, Ludewig, Burkhard, Coles, Mark C.

“…Through the formation of concentration gradients, morphogens drive graded responses to extracellular signals, thereby fine-tuning cell behaviors in complex…”
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PI16+ reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches by De Martin, Angelina, Stanossek, Yves, Lütge, Mechthild, Cadosch, Nadine, Onder, Lucas, Cheng, Hung-Wei, Brandstadter, Joshua D., Maillard, Ivan, Stoeckli, Sandro J., Pikor, Natalia B., Ludewig, Burkhard

“…Fibroblastic reticular cells (FRCs) direct the interaction and activation of immune cells in discrete microenvironments of lymphoid organs. Despite their…”
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Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis by Onder, Lucas, Mörbe, Urs, Pikor, Natalia, Novkovic, Mario, Cheng, Hung-Wei, Hehlgans, Thomas, Pfeffer, Klaus, Becher, Burkhard, Waisman, Ari, Rülicke, Thomas, Gommerman, Jennifer, Mueller, Christopher G., Sawa, Shinichiro, Scandella, Elke, Ludewig, Burkhard

“…Lymph nodes (LNs) are strategically situated throughout the body at junctures of the blood vascular and lymphatic systems to direct immune responses against…”
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B Cells in the Multiple Sclerosis Central Nervous System: Trafficking and Contribution to CNS-Compartmentalized Inflammation by Michel, Laure, Touil, Hanane, Pikor, Natalia B, Gommerman, Jennifer L, Prat, Alexandre, Bar-Or, Amit

“…Clinical trial results of peripheral B cell depletion indicate abnormal proinflammatory B cell properties, and particularly antibody-independent functions,…”
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Conserved stromal–immune cell circuits secure B cell homeostasis and function by Lütge, Mechthild, De Martin, Angelina, Gil-Cruz, Cristina, Perez-Shibayama, Christian, Stanossek, Yves, Onder, Lucas, Cheng, Hung-Wei, Kurz, Lisa, Cadosch, Nadine, Soneson, Charlotte, Robinson, Mark D., Stoeckli, Sandro J., Ludewig, Burkhard, Pikor, Natalia B.

“…B cell zone reticular cells (BRCs) form stable microenvironments that direct efficient humoral immunity with B cell priming and memory maintenance being…”
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Meningeal Tertiary Lymphoid Tissues and Multiple Sclerosis: A Gathering Place for Diverse Types of Immune Cells during CNS Autoimmunity by Pikor, Natalia B, Prat, Alexandre, Bar-Or, Amit, Gommerman, Jennifer L

“…Collections of leukocytes in the meningeal space have been documented in Multiple Sclerosis (MS). These meningeal aggregates, which in the context of other…”
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An Innate Checkpoint Determines Immune Dysregulation and Immunopathology during Pulmonary Murine Coronavirus Infection by Grabherr, Sarah, Waltenspühl, Alexandra, Büchler, Lorina, Lütge, Mechthild, Cheng, Hung-Wei, Caviezel-Firner, Sonja, Ludewig, Burkhard, Krebs, Philippe, Pikor, Natalia B

“…Hallmarks of life-threatening, coronavirus-induced disease include dysregulated antiviral immunity and immunopathological tissue injury. Nevertheless, the…”
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Stromal Cell Niches in the Inflamed Central Nervous System by Pikor, Natalia B, Cupovic, Jovana, Onder, Lucas, Gommerman, Jennifer L, Ludewig, Burkhard

“…Inflammation in the CNS must be tightly regulated to respond efficiently to infection with neurotropic pathogens. Access of immune cells to the CNS and their…”
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Secondary B cell receptor diversification is necessary for T cell mediated neuro-inflammation during experimental autoimmune encephalomyelitis by Galicia, Georgina, Boulianne, Bryant, Pikor, Natalia, Martin, Alberto, Gommerman, Jennifer L

“…Clinical studies of B cell depletion in Multiple Sclerosis (MS) have revealed that B Lymphocytes are involved in the neuro-inflammatory process, yet it remains…”
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A sphingosine-1-phosphate receptor 1-directed agonist reduces central nervous system inflammation in a plasmacytoid dendritic cell-dependent manner by Galicia-Rosas, Georgina, Pikor, Natalia, Schwartz, Jordan A, Rojas, Olga, Jian, Allen, Summers-Deluca, Leslie, Ostrowski, Mario, Nuesslein-Hildesheim, Barbara, Gommerman, Jennifer L

“…Gradients of the sphingolipid sphingosine-1-phosphate (S1P) are responsible for the egress of lymphocytes from lymph nodes by activating the S1P1 receptor…”
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Substrain Differences Reveal Novel Disease-Modifying Gene Candidates That Alter the Clinical Course of a Rodent Model of Multiple Sclerosis by deLuca, Leslie E. Summers, Pikor, Natalia B, O'Leary, Jennifer, Galicia-Rosas, Georgina, Ward, Lesley A, Defreitas, Dustin, Finlay, Trisha M, Ousman, Shalina S, Osborne, Lucy R, Gommerman, Jennifer L

“…Experimental autoimmune encephalomyelitis (EAE) is a rodent model of multiple sclerosis that is executed in animals by immunization with myelin Ag in adjuvant…”
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Postvaccination anti-S IgG levels predict anti-SARS-CoV-2 neutralising activity over 24 weeks in patients with RA by Schmiedeberg, Kristin, Abela, Irene A, Pikor, Natalia Barbara, Vuilleumier, Nicolas, Schwarzmueller, Magdalena, Epp, Selina, Pagano, Sabrina, Grabherr, Sarah, Patterson, Angelica Brooke, Nussberger, Madalina, Trkola, Alexandra, Ludewig, Burkhard, von Kempis, Johannes, Rubbert-Roth, Andrea

“…ObjectivesTo correlate immune responses following a two-dose regimen of mRNA anti-SARS-CoV-2 vaccines in patients with rheumatoid arthritis (RA) to the…”
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Insights into coronavirus immunity taught by the murine coronavirus by Grabherr, Sarah, Ludewig, Burkhard, Pikor, Natalia Barbara

“…Coronaviruses (CoVs) represent enveloped, ss RNA viruses with the ability to infect a range of vertebrates causing mainly lung, CNS, enteric, and hepatic…”
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Protective fibroblastic niches in secondary lymphoid organs by De Martin, Angelina, Stanossek, Yves, Pikor, Natalia Barbara, Ludewig, Burkhard

“…Fibroblastic reticular cells (FRCs) are specialized fibroblasts of secondary lymphoid organs that provide the structural foundation of the tissue. Moreover,…”
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Development and Immunological Function of Lymph Node Stromal Cells by Pikor, Natalia Barbara, Cheng, Hung-Wei, Onder, Lucas, Ludewig, Burkhard

“…Stromal cells have for a long time been viewed as structural cells that support distinct compartments within lymphoid tissues and little more. Instead, an…”
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CCL19-producing fibroblastic stromal cells restrain lung carcinoma growth by promoting local antitumor T-cell responses by Cheng, Hung-Wei, Onder, Lucas, Cupovic, Jovana, Boesch, Maximilian, Novkovic, Mario, Pikor, Natalia, Tarantino, Ignazio, Rodriguez, Regulo, Schneider, Tino, Jochum, Wolfram, Brutsche, Martin, Ludewig, Burkhard

“…A particular characteristic of non–small cell lung cancer is the composition of the tumor microenvironment with a very high proportion of fibroblastic stromal…”
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