Search Results - "Pike See, Cheah"

Mitochondrial Dysfunction in Down Syndrome: From Pathology to Therapy by Tan, Kai-Leng, Lee, Han-Chung, Cheah, Pike-See, Ling, King-Hwa

“…•Mitochondrial dysfunctions in Down syndrome are characterised by changes in the morphology, function, biogenesis and dynamics and gene…”
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Evaluation of wound healing properties of bioactive aqueous fraction from Moringa oleifera Lam on experimentally induced diabetic animal model by Muhammad, Abubakar Amali, Arulselvan, Palanisamy, Cheah, Pike See, Abas, Farida, Fakurazi, Sharida

“…Diabetic foot ulcer is a serious complication of diabetes, which affects a significant percentage (15%) of diabetics and up to 15%-24% of those affected may…”
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REST in the Road Map of Brain Development by Lam, Xin-Jieh, Maniam, Sandra, Cheah, Pike-See, Ling, King-Hwa

“…Repressor element-1 silencing transcription factor (REST) or also known as neuron-restrictive silencing factor (NRSF), is the key initiator of epigenetic…”
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REST Targets JAK-STAT and HIF-1 Signaling Pathways in Human Down Syndrome Brain and Neural Cells by Huang, Tan, Fakurazi, Sharida, Cheah, Pike-See, Ling, King-Hwa

“…Down syndrome (DS) is the most frequently diagnosed chromosomal disorder of chromosome 21 (HSA21) aneuploidy, characterized by intellectual disability and…”
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Mitragynine Attenuates Morphine Withdrawal Effects in Rats-A Comparison With Methadone and Buprenorphine by Hassan, Rahimah, Pike See, Cheah, Sreenivasan, Sasidharan, Mansor, Sharif M, Müller, Christian P, Hassan, Zurina

“…Opiate addiction is a major health problem in many countries. A crucial component of the medical treatment is the management of highly aversive opiate…”
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Screening of brain-derived neurotrophic factor (BDNF) single nucleotide polymorphisms and plasma BDNF levels among Malaysian major depressive disorder patients by Aldoghachi, Asraa Faris, Tor, Yin Sim, Redzun, Siti Zubaidah, Lokman, Khairul Aiman Bin, Razaq, Nurul Asyikin Abdul, Shahbudin, Aishah Farhana, Badamasi, Ibrahim Mohamed, Cheah, Pike-See, Stanslas, Johnson, Veerakumarasivam, Abhi, Rosli, Rozita, Ibrahim, Normala, Lye, Munn Sann, Ling, King-Hwa

“…Brain-derived neurotrophic factor (BDNF) is a neurotrophin found in abundance in brain regions such as the hippocampus, cortex, cerebellum and basal forebrain…”
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AAV9 transduction mediated by systemic delivery of vector via retro-orbital injection in newborn, neonatal and juvenile mice by Prabhakar, Shilpa, Lule, Sevda, Hora, Cintia Carla da, Breakefield, Xandra O., Cheah, Pike See

“…Adeno-associated virus (AAV)-based gene therapy is gaining popularity owing to its excellent safety profile and effective therapeutic outcomes in a number of…”
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Transient prenatal ruxolitinib treatment suppresses astrogenesis during development and improves learning and memory in adult mice by Lee, Han-Chung, Hamzah, Hamizun, Leong, Melody Pui-Yee, Md Yusof, Hadri, Habib, Omar, Zainal Abidin, Shahidee, Seth, Eryse Amira, Lim, Siong-Meng, Vidyadaran, Sharmili, Mohd Moklas, Mohamad Aris, Abdullah, Maizaton Atmadini, Nordin, Norshariza, Hassan, Zurina, Cheah, Pike-See, Ling, King-Hwa

“…Ruxolitinib is the first janus kinase 1 (JAK1) and JAK2 inhibitor that was approved by the United States Food and Drug Administration (FDA) agency for the…”
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Defects in nerve conduction velocity and different muscle fibre-type specificity contribute to muscle weakness in Ts1Cje Down syndrome mouse model by Bala, Usman, Leong, Melody Pui-Yee, Lim, Chai Ling, Shahar, Hayati Kadir, Othman, Fauziah, Lai, Mei-I, Law, Zhe-Kang, Ramli, Khairunnisa, Htwe, Ohnmar, Ling, King-Hwa, Cheah, Pike-See

“…Down syndrome (DS) is a genetic disorder caused by presence of extra copy of human chromosome 21. It is characterised by several clinical phenotypes. Motor…”
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Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks by Ling, King-Hwa, Hewitt, Chelsee A, Tan, Kai-Leng, Cheah, Pike-See, Vidyadaran, Sharmili, Lai, Mei-I, Lee, Han-Chung, Simpson, Ken, Hyde, Lavinia, Pritchard, Melanie A, Smyth, Gordon K, Thomas, Tim, Scott, Hamish S

“…The Ts1Cje mouse model of Down syndrome (DS) has partial triplication of mouse chromosome 16 (MMU16), which is partially homologous to human chromosome 21…”
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Phenotype microarrays reveal metabolic dysregulations of neurospheres derived from embryonic Ts1Cje mouse model of Down syndrome by Seth, Eryse Amira, Lee, Han-Chung, Yusof, Hadri Hadi bin Md, Nordin, Norshariza, Cheah, Yoke Kqueen, Ho, Eric Tatt Wei, Ling, King-Hwa, Cheah, Pike-See

“…Down syndrome (DS), is the most common cause of intellectual disability, and is characterized by defective neurogenesis during perinatal development. To…”
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Step-by-step approach: Stereotaxic surgery for in vivo extracellular field potential recording at the rat Schaffer collateral-CA1 synapse using the eLab system by Azimzadeh, Mansour, Mohd Azmi, Mohd Amirul Najwa, Reisi, Parham, Cheah, Pike-See, Ling, King-Hwa

“…In vivo extracellular field potential recording is a commonly used technique in modern neuroscience research. The success of long-term electrophysiological…”
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Mitochondria dysfunction and bipolar disorder: From pathology to therapy by Lam, Xin-Jieh, Xu, Bingzhe, Yeo, Pei-Ling, Cheah, Pike-See, Ling, King-Hwa

“…Bipolar disorder (BD) is one of the major psychiatric diseases in which the impairment of mitochondrial functions has been closely connected or associated with…”
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Molecular genetics of the developing neuroendocrine hypothalamus by Szarek, Eva, Cheah, Pike-See, Schwartz, Jeff, Thomas, Paul

“…Formation of the mammalian endocrine system and neuroendocrine organs involves complex regulatory networks resulting in a highly specialized cell system able…”
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Anatomic Variation in Morphometry of Human Coracoid Process among Asian Population by Othman, Fauziah, Mahmud, Rozi, Abdul Rahim, Ezamin, San, Aye Aye, Nasir, M. Nizlan, Ahmad, Umar, Cheah, Pike-See, Fathi, Manal, Hussin, Paisal

“…Ethnic origin plays an important role in bone morphometry. Studies examining the influence of coracoid process have focused primarily on adults and have not…”
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Potential Role of JAK-STAT Signaling Pathway in the Neurogenic-to-Gliogenic Shift in Down Syndrome Brain by Ling, King-Hwa, Cheah, Pike-See, Tan, Kai-Leng, Lee, Han-Chung

“…Trisomy of human chromosome 21 in Down syndrome (DS) leads to several phenotypes, such as mild-to-severe intellectual disability, hypotonia, and craniofacial…”
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Expression Profiling of Notch Signalling Pathway and Gamma-Secretase Activity in the Brain of Ts1Cje Mouse Model of Down Syndrome by Yusof, Hadri Hadi, Lee, Han-Chung, Seth, Eryse Amira, Wu, Xiangzhong, Hewitt, Chelsee A., Scott, Hamish S, Cheah, Pike-See, Li, Yue-Ming, Chau, De-Ming, Ling, King-Hwa

“…Notch signalling pathway is involved in the proliferation of neural progenitor cells (NPCs), to inhibit neuronal cell commitment and to promote glial cell…”
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In Silico Prediction and Validation of Gfap as an miR-3099 Target in Mouse Brain by Abidin, Shahidee Zainal, Leong, Jia-Wen, Mahmoudi, Marzieh, Nordin, Norshariza, Abdullah, Syahril, Cheah, Pike-See, Ling, King-Hwa

“…MicroRNAs are small non-coding RNAs that play crucial roles in the regulation of gene expression and protein synthesis during brain development. MiR-3099 is…”
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Gene therapy for tuberous sclerosis complex type 2 in a mouse model by delivery of AAV9 encoding a condensed form of tuberin by Cheah, Pike-See, Prabhakar, Shilpa, Yellen, David, Beauchamp, Roberta L, Zhang, Xuan, Kasamatsu, Shingo, Bronson, Roderick T, Thiele, Elizabeth A, Kwiatkowski, David J, Stemmer-Rachamimov, Anat, György, Bence, Ling, King-Hwa, Kaneki, Masao, Tannous, Bakhos A, Ramesh, Vijaya, Maguire, Casey A, Breakefield, Xandra O

“…Tuberous sclerosis complex (TSC) results from loss of a tumor suppressor gene - 1 or 2, encoding hamartin and tuberin, respectively. These proteins formed a…”
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Deep sequencing analysis of the developing mouse brain reveals a novel microRNA by Ling, King-Hwa, Brautigan, Peter J, Hahn, Christopher N, Daish, Tasman, Rayner, John R, Cheah, Pike-See, Raison, Joy M, Piltz, Sandra, Mann, Jeffrey R, Mattiske, Deidre M, Thomas, Paul Q, Adelson, David L, Scott, Hamish S

“…MicroRNAs (miRNAs) are small non-coding RNAs that can exert multilevel inhibition/repression at a post-transcriptional or protein synthesis level during…”
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