Search Results - "Pike, Martin M"

Increased 20-HETE Signaling Suppresses Capillary Neurovascular Coupling After Ischemic Stroke in Regions Beyond the Infarct by Li, Zhenzhou, McConnell, Heather L, Stackhouse, Teresa L, Pike, Martin M, Zhang, Wenri, Mishra, Anusha

“…Neurovascular coupling, the process by which neuronal activity elicits increases in the local blood supply, is impaired in stroke patients in brain regions…”
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Dysfunctional cilia lead to altered ependyma and choroid plexus function, and result in the formation of hydrocephalus by Banizs, Boglarka, Pike, Martin M, Millican, C Leigh, Ferguson, William B, Komlosi, Peter, Sheetz, James, Bell, Phillip D, Schwiebert, Erik M, Yoder, Bradley K

“…Cilia are complex organelles involved in sensory perception and fluid or cell movement. They are constructed through a highly conserved process called…”
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GPR39 Deficiency Impairs Memory and Alters Oxylipins and Inflammatory Cytokines Without Affecting Cerebral Blood Flow in a High-Fat Diet Mouse Model of Cognitive Impairment by Bah, Thierno M, Allen, Elyse M, Garcia-Jaramillo, Manuel, Perez, Ruby, Zarnegarnia, Yalda, Davis, Catherine M, Bloom, Madeline B, Magana, Armando A, Choi, Jaewoo, Bobe, Gerd, Pike, Martin M, Raber, Jacob, Maier, Claudia S, Alkayed, Nabil J

“…Vascular cognitive impairment (VCI) is the second most common cause of dementia. There is no treatment for VCI, in part due to a lack of understanding of the…”
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Dynamic MRI using iron oxide nanoparticles to assess early vascular effects of antiangiogenic versus corticosteroid treatment in a glioma model by Varallyay, Csanad G, Muldoon, Leslie L, Gahramanov, Seymur, Wu, Yingjen J, Goodman, James A, Li, Xin, Pike, Martin M, Neuwelt, Edward A

“…The vascular effects of antiangiogenic treatment may pose problems for evaluating brain tumor response based on contrast-enhanced magnetic resonance imaging…”
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Neurobehavioral and Imaging Correlates of Hippocampal Atrophy in a Mouse Model of Vascular Cognitive Impairment by Zuloaga, Kristen L., Zhang, Wenri, Yeiser, Lauren A., Stewart, Blair, Kukino, Ayaka, Nie, Xiao, Roese, Natalie E., Grafe, Marjorie R., Pike, Martin M., Raber, Jacob, Alkayed, Nabil J.

“…Vascular cognitive impairment (VCI) is the second most common cause of dementia. Reduced cerebral blood flow is thought to play a major role in the etiology of…”
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Combined efficacy of cediranib and quinacrine in glioma is enhanced by hypoxia and causally linked to autophagic vacuole accumulation by Lobo, Merryl R, Wang, Xiaoyan, Gillespie, G Yancey, Woltjer, Randall L, Pike, Martin M

“…We have previously reported that the in vivo anti-glioma efficacy of the anti-angiogenic receptor tyrosine kinase inhibitor cediranib is substantially enhanced…”
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Synergistic Antivascular and Antitumor Efficacy with Combined Cediranib and SC6889 in Intracranial Mouse Glioma by Lobo, Merryl R, Kukino, Ayaka, Tran, Huong, Schabel, Matthias C, Springer, Jr, Charles S, Gillespie, G Yancey, Grafe, Marjorie R, Woltjer, Randall L, Pike, Martin M

“…Prognosis remains extremely poor for malignant glioma. Targeted therapeutic approaches, including single agent anti-angiogenic and proteasome inhibition…”
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A new model of cortical stroke in the rhesus macaque by West, G Alexander, Golshani, Kiarash J, Doyle, Kristian P, Lessov, Nikola S, Hobbs, Theodore R, Kohama, Steven G, Pike, Martin M, Kroenke, Christopher D, Grafe, Marjorie R, Spector, Maxwell D, Tobar, Eric T, Simon, Roger P, Stenzel-Poore, Mary P

“…Primate models are essential tools for translational research in stroke but are reportedly inconsistent in their ability to produce cortical infarcts of…”
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Aquaporin-4-dependent glymphatic solute transport in the rodent brain by Mestre, Humberto, Hablitz, Lauren M, Xavier, Anna Lr, Feng, Weixi, Zou, Wenyan, Pu, Tinglin, Monai, Hiromu, Murlidharan, Giridhar, Castellanos Rivera, Ruth M, Simon, Matthew J, Pike, Martin M, Plá, Virginia, Du, Ting, Kress, Benjamin T, Wang, Xiaowen, Plog, Benjamin A, Thrane, Alexander S, Lundgaard, Iben, Abe, Yoichiro, Yasui, Masato, Thomas, John H, Xiao, Ming, Hirase, Hajime, Asokan, Aravind, Iliff, Jeffrey J, Nedergaard, Maiken

“…The glymphatic system is a brain-wide clearance pathway; its impairment contributes to the accumulation of amyloid-β. Influx of cerebrospinal fluid (CSF)…”
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High fat diet-induced diabetes in mice exacerbates cognitive deficit due to chronic hypoperfusion by Zuloaga, Kristen L, Johnson, Lance A, Roese, Natalie E, Marzulla, Tessa, Zhang, Wenri, Nie, Xiao, Alkayed, Farah N, Hong, Christine, Grafe, Marjorie R, Pike, Martin M, Raber, Jacob, Alkayed, Nabil J

“…Diabetes causes endothelial dysfunction and increases the risk of vascular cognitive impairment. However, it is unknown whether diabetes causes cognitive…”
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Metabolic activity diffusion imaging (MADI): I. Metabolic, cytometric modeling and simulations by Springer, Charles S., Baker, Eric M., Li, Xin, Moloney, Brendan, Wilson, Gregory J., Pike, Martin M., Barbara, Thomas M., Rooney, William D., Maki, Jeffrey H.

“…Evidence mounts that the steady‐state cellular water efflux (unidirectional) first‐order rate constant (kio [s−1]) magnitude reflects the ongoing, cellular…”
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Soluble epoxide hydrolase inhibition reverses cognitive dysfunction in a mouse model of metabolic syndrome by modulating inflammation by Bah, Thierno M., Davis, Catherine M., Allen, Elyse M., Borkar, Rohan N., Perez, Ruby, Grafe, Marjorie R., Raber, Jacob, Pike, Martin M., Alkayed, Nabil J.

“…Midlife metabolic syndrome (MetS) is associated with cognitive impairment in late life. The mechanism of delayed MetS-related cognitive dysfunction (MetSCD) is…”
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Metabolic activity diffusion imaging (MADI): II. Noninvasive, high‐resolution human brain mapping of sodium pump flux and cell metrics by Springer, Charles S., Baker, Eric M., Li, Xin, Moloney, Brendan, Pike, Martin M., Wilson, Gregory J., Anderson, Valerie C., Sammi, Manoj K., Garzotto, Mark G., Kopp, Ryan P., Coakley, Fergus V., Rooney, William D., Maki, Jeffrey H.

“…We introduce a new 1H2O magnetic resonance approach: metabolic activity diffusion imaging (MADI). Numerical diffusion‐weighted imaging decay simulations…”
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Rearing environment influences boldness and prey acquisition behavior, and brain and lens development of bull trout by Brignon, William R., Pike, Martin M., Ebbesson, Lars O. E., Schaller, Howard A., Peterson, James T., Schreck, Carl B.

“…Animals reared in barren captive environments exhibit different developmental trajectories and behaviors than wild counterparts. Hence, the captive phenotypes…”
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High-dose estrogen treatment at reperfusion reduces lesion volume and accelerates recovery of sensorimotor function after experimental ischemic stroke by Carpenter, Randall S, Iwuchukwu, Ifeanyi, Hinkson, Cyrus L, Reitz, Sydney, Lee, Wonhee, Kukino, Ayaka, Zhang, An, Pike, Martin M, Ardelt, Agnieszka A

“…Abstract Estrogens have previously been shown to protect the brain against acute ischemic insults, by potentially augmenting cerebrovascular function after…”
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Age-dependent cognitive impairment, hydrocephalus and leukocyte infiltration in transgenic mice with endothelial expression of human EPHX2 by Davis, Catherine M., Zhang, Wenri H., Bah, Thierno M., Roese, Natalie E., Allen, Elyse M., Leung, Philberta, Boutros, Sydney J., Marzulla, Tessa, Patel, Esha, Nie, Xiao, Alkayed, Farah N., Huang, Justin H., Jensen, Michael A., Raber, Jacob, Pike, Martin M., Alkayed, Nabil J.

“…Soluble epoxide hydrolase (sEH) is upregulated in microvascular endothelium of human brain with vascular cognitive impairment (VCI). Transgenic endothelial…”
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Quinacrine synergistically enhances the antivascular and antitumor efficacy of cediranib in intracranial mouse glioma by Lobo, Merryl R, Green, Sarah C, Schabel, Matthias C, Gillespie, G Yancey, Woltjer, Randall L, Pike, Martin M

“…Despite malignant glioma vascularity, anti-angiogenic therapy is largely ineffective. We hypothesize that efficacy of the antiangiogenic agent cediranib is…”
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Dynamic-contrast-enhanced-MRI with extravasating contrast reagent: Rat cerebral glioma blood volume determination by Li, Xin, Rooney, William D., Várallyay, Csanád G., Gahramanov, Seymur, Muldoon, Leslie L., Goodman, James A., Tagge, Ian J., Selzer, Audrey H., Pike, Martin M., Neuwelt, Edward A., Springer, Charles S.

“…The accurate mapping of the tumor blood volume (TBV) fraction ( v b) is a highly desired imaging biometric goal. It is commonly thought that achieving this is…”
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Estradiol modulates post-ischemic cerebral vascular remodeling and improves long-term functional outcome in a rat model of stroke by Ardelt, Agnieszka A, Carpenter, Randall S, Lobo, Merryl R, Zeng, Huadong, Solanki, Rajanikant B, Zhang, An, Kulesza, Piotr, Pike, Martin M

“…Abstract We previously observed that 17β-estradiol (E2) augments ischemic borderzone vascular density 10 days after focal cerebral ischemia–reperfusion in…”
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Fasudil prevents KATP channel-induced improvement in postischemic functional recovery by Nishizawa, Kenya, Wolkowicz, Paul E, Yamagishi, Tadashi, Guo, Ling-Ling, Pike, Martin M

“…Whereas activation of ATP-dependent potassium (K(ATP)) channels greatly improves postischemic myocardial recovery, the final effector mechanism for K(ATP)…”
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