Search Results - "Pike, Marilyn C"

Phase 1 safety and tolerability study of BMP-7 in symptomatic knee osteoarthritis by Hunter, David J, Pike, Marilyn C, Jonas, Beth L, Kissin, Eugene, Krop, Julie, McAlindon, Tim

“…There are no proven therapies that modify the structural changes associated with osteoarthritis (OA). Preclinical data suggests that intra-articular…”
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Data Quality Challenges in Systemic Lupus Erythematosus Trials: How Can This Be Optimized? by Pike, Marilyn C., Kelley, Lexy

“…Major scientific advances in basic science, pharmacology, and translational medicine have allowed the discovery of new molecular targets whose manipulation by…”
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N-Terminus Urea-Substituted Chemotactic Peptides:  New Potent Agonists and Antagonists toward the Neutrophil fMLF Receptor by Higgins, John D, Bridger, Gary J, Derian, Claudia K, Beblavy, Michael J, Hernandez, Pedro E, Gaul, Forrest E, Abrams, Michael J, Pike, Marilyn C, Solomon, Howard F

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Biologic and Biochemical Activities of Continuous Macrophage Cell Lines P388D1 and J774.1 by Snyderman, Ralph, Pike, Marilyn C, Fischer, Dina G, Koren, Hillel S

“…Abstract The study of continuous lines of murine cells with macrophage-like properties may provide important information concerning biochemical parameters…”
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Selective Inhibition of N-Formylpeptide-Induced Neutrophil Activation by Carbamate-Modified Peptide Analogues by Derian, Claudia K, Solomon, Howard F, Higgins, John D, Beblavy, Michael J, Santulli, Rosemary J, Bridger, Gary J, Pike, Marilyn C, Kroon, Daniel J, Fischman, Alan J

“…Stimulation of the leukocyte N-formylpeptide receptor (FPR) induces chemotaxis, cell adhesion, free radical release, and degranulation, responses associated…”
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Depression of Macrophage Function by a Factor Produced by Neoplasms: A Mechanism for Abrogation of Immune Surveillance by Pike, Marilyn C, Snyderman, Ralph

“…Abstract The possibility that macrophages mediate surveillance against the development of neoplasms has been receiving increasing support. The acquisition, by…”
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Phospholipid Methylation in Macrophages is Inhibited by Chemotactic Factors by Pike, Marilyn C., Kredich, Nicholas M., Snyderman, Ralph

“…Chemotaxis by human monocytes has been shown to require methylation mediated by S-adenosyl-L-methionine(AdoMet), but the specific transmethylation reaction…”
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Augmentation of human monocyte chemotactic response by levamisole by PIKE, MARILYN C, SNYDERMAN, RALPH

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Effects of Neoplasms on Inflammation: Depression of Macrophage Accumulation after Tumor Implantation by Snyderman, Ralph, Pike, Marilyn C, Blaylock, Barbara L, Weinstein, Phillip

“…The local accumulation of macrophages at sites of neoplasms may be a critical event in immunologically mediated tumor killing. Individuals with neoplasms,…”
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Technetium-99m-Labeled Hydrazino Nicotinamide Derivatized Chemotactic Peptide Analogs for Imaging Focal Sites of Bacterial Infection by Babich, John W, Solomon, Howard, Pike, Marilyn C, Kroon, Daniel, Graham, Wendy, Abrams, Michael J, Tompkins, Ronald G, Rubin, Robert H, Fischman, Alan J

“…We synthesized and evaluated four hydrazino nicotinamide (HYNIC) derivatized chemotactic peptide analogs: For-NleLFK-HYNIC (HP1), For-MLFK-HYNIC (HP2),…”
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Imaging Focal Sites of Bacterial Infection in Rats with Indium-111-Labeled Chemotactic Peptide Analogs by Fischman, Alan J, Pike, Marilyn C, Kroon, Daniel, Fucello, Anthony J, Rexinger, Douglas, tenKate, Caroline, Wilkinson, Robert, Rubin, Robert H, Strauss, H. William

“…Four DTPA-derivatized chemotactic peptide analogs: ForNleLFNleYK-DTPA (P1), ForMLFNH(CH2)6NH-DTPA (P2), ForNleLFK(NH2)-DTPA (P3), and ForNleLFK-DTPA (P4), were…”
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Characterization of interleukin-8 receptors in human neutrophil membranes: regulation by guanine nucleotides by Barnett, M L, Lamb, K A, Costello, K M, Pike, M C

“…Interleukin-8 (IL-8) is a polymorphonuclear leukocyte (PMN) chemoattractant and activator which mediates its effects through specific cell-surface receptors…”
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Specific Receptor Sites for Chemotactic Peptides on Human Polymorphonuclear Leukocytes by Williams, Lewis T., Snyderman, Ralph, Pike, Marilyn C., Lefkowitz, Robert J.

“…Synthetic N-formylmethionyl peptides are chemotactic attractants for human polymorphonuclear leukocytes. The well-defined structure-activity relationship of…”
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Chemoattractant-Mediated Stimulation of the Respiratory Burst in Human Polymorphonuclear Leukocytes May Require Appearance of Protein Kinase Activity in the Cells’ Particulate Fraction by Pike, Marilyn C., Jakoi, Laszlo, McPhail, Linda C., Snyderman, Ralph

“…Low doses of aliphatic alcohols produce divergent effects on the function of chemoattractant receptors on human polymorphonuclear leukocytes (PMNs) since they…”
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Transmethylation reactions regulate affinity and functional activity of chemotactic factor receptors on macrophages by Pike, M C, Snyderman, R

“…Methylation mediated by S-adenosyl-L-methionine is required for the chemotaxis of mononuclear leukocytes. We investigated whether transmethylation reactions…”
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Stimulation of human polymorphonuclear leukocyte phosphatidylinositol-4- phosphate kinase by concanavalin A and formyl-methionyl-leucyl- phenylalanine is calcium-independent. Correlation with maintenance of actin assembly by Pike, MC, Costello, K, Southwick, FS

“…Chemoattractants directly stimulate the enzyme activity that synthesizes phosphatidylinositol-4,5-bisphosphate (PIP2), phosphoinositol-4-monophosphate (PIP)…”
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IL-8 stimulates phosphatidylinositol-4-phosphate kinase in human polymorphonuclear leukocytes by Pike, MC, Costello, KM, Lamb, KA

“…IL-8 is a neutrophil-specific chemoattractant and cellular activator which exists in at least three forms, 69, 72, and 77 amino acids. The predominant monocyte…”
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N-Formylmethionyl Peptide Receptors on Equine Leukocytes Initiate Secretion but not Chemotaxis by Snyderman, Ralph, Pike, Marilyn C.

“…The chemotaxis of leukocytes appears to be initiated by the binding of chemotactic factors to the surface of these cells. N-Formylated peptides induce…”
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Requirement of S-adenosyl-L-methionine-Mediated Methylation for Human Monocyte Chemotaxis by Pike, Marilyn C., Kredich, Nicholas M., Snyderman, Ralph

“…The chemotactic response of motile bacteria requires the methylation of specific proteins by S-adenosyl-L-methionine. To determine whether methylation is…”
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An Inhibitor of Macrophage Chemotaxis Produced by Neoplasms by Snyderman, Ralph, Pike, Marilyn C.

“…The accumulation of macrophages at neoplastic sites may be an important event in immunologically mediated tumor killing. The implantation of syngeneic…”
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