Search Results - "Pike, Luke R. G."

Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival by Pike, Luke R G, Singleton, Dean C, Buffa, Francesca, Abramczyk, Olga, Phadwal, Kanchan, Li, Ji-Liang, Simon, Anna Katharina, Murray, James T, Harris, Adrian L

“…Hypoxia in the microenvironment of many solid tumours is an important determinant of malignant progression. The ISR (integrated stress response) protects cells…”
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Genomic analysis and clinical correlations of non-small cell lung cancer brain metastasis by Skakodub, Anna, Walch, Henry, Tringale, Kathryn R., Eichholz, Jordan, Imber, Brandon S., Vasudevan, Harish N., Li, Bob T., Moss, Nelson S., Hei Yu, Kenny Kwok, Mueller, Boris A., Powell, Simon, Razavi, Pedram, Yu, Helena A., Reis-Filho, Jorge S., Gomez, Daniel, Schultz, Nikolaus, Pike, Luke R. G.

“…Up to 50% of patients with non-small cell lung cancer (NSCLC) develop brain metastasis (BM), yet the study of BM genomics has been limited by tissue access,…”
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Safety of combining radiotherapy with immune-checkpoint inhibition by Hwang, William L., Pike, Luke R. G., Royce, Trevor J., Mahal, Brandon A., Loeffler, Jay S.

“…Immune-checkpoint inhibitors targeting cytotoxic T- lymphocyte antigen 4 (CTLA-4), programmed cell death protein 1 (PD-1), or programmed cell death 1 ligand 1…”
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Symptomatic Necrosis With Antibody-Drug Conjugates and Concurrent Stereotactic Radiotherapy for Brain Metastases by Lebow, Emily S, Pike, Luke R G, Seidman, Andrew D, Moss, Nelson, Beal, Kathryn, Yu, Yao

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Biomarkers in Nonmetastatic Castrate-Resistant Prostate Cancer: A Step in the Right Direction by Yang, David D, Mahal, Brandon A, Pike, Luke R G

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Outcomes Following Early Postoperative Adjuvant Radiosurgery for Brain Metastases by Bander, Evan D, El Ahmadieh, Tarek Y, Chen, Justin, Reiner, Anne S, Brown, Samantha, Giantini-Larsen, Alexandra M, Young, Robert J, Beal, Kathryn, Imber, Brandon S, Pike, Luke R G, Brennan, Cameron W, Tabar, Viviane, Panageas, Katherine S, Moss, Nelson S

“…Adjuvant stereotactic radiosurgery (SRS) enhances the local control of resected brain metastases (BrM). However, the risks of local failure (LF) and potential…”
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Palliative Radiation Therapy for Vertebral Metastases and Metastatic Cord Compression in Patients Treated With Anti-PD-1 Therapy by Fareed, Muhammad Mohsin, Pike, Luke R G, Bang, Andrew, Huynh, Mai Anh, Taylor, Allison, Spektor, Alexander, Awad, Mark M, Ott, Patrick A, Krishnan, Monica, Balboni, Tracy A, Schoenfeld, Jonathan D

“…There is increasing use of immune checkpoint blockade (ICB) across multiple cancer types, including in patients at risk for vertebral metastases and cord…”
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ATF4 orchestrates a program of BH3-only protein expression in severe hypoxia by Pike, Luke R. G., Phadwal, Kanchan, Simon, Anna Katharina, Harris, Adrian L.

“…Intratumoral hypoxia is associated with poor prognosis, regardless of the mode of therapy. Cancer cells survive this condition through activating several…”
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Improved CNS Control With the Addition of Chemotherapy to Osimertinib: A Devil's Bargain? by Yu, Yao, Miao, Emily, Pike, Luke R G

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The Impact of Radiation Therapy on Lymphocyte Count and Survival in Metastatic Cancer Patients Receiving PD-1 Immune Checkpoint Inhibitors by Pike, Luke R.G., Bang, Andrew, Mahal, Brandon A., Taylor, Allison, Krishnan, Monica, Spektor, Alexander, Cagney, Daniel N., Aizer, Ayal A., Alexander, Brian M., Rahma, Osama, Balboni, Tracy, Ott, Patrick A., Hodi, F. Stephen, Schoenfeld, Jonathan D.

“…Therapeutic radiation has conflicting immune effects: radiation therapy (RT)-induced immunogenic cell death can contribute to immune response, but lymphocytes…”
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Multicenter Evaluation of the Tolerability of Combined Treatment With PD-1 and CTLA-4 Immune Checkpoint Inhibitors and Palliative Radiation Therapy by Bang, Andrew, Wilhite, Tyler J., Pike, Luke R.G., Cagney, Daniel N., Aizer, Ayal A., Taylor, Allison, Spektor, Alexander, Krishnan, Monica, Ott, Patrick A., Balboni, Tracy A., Hodi, F. Stephen, Schoenfeld, Jonathan D.

“…To analyze immune-related adverse events (ir-AEs) in patients treated with radiation and immune checkpoint blockade. We retrospectively reviewed records from…”
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Real-World Use of Hypofractionated Radiotherapy for Primary CNS Tumors in the Elderly, and Implications on Medicare Spending by Tringale, Kathryn R, Lin, Andrew, Miller, Alexandra M, Khan, Atif, Chen, Linda, Zinovoy, Melissa, Yamada, Yoshiya, Yu, Yao, Pike, Luke R G, Imber, Brandon S

“…For elderly patients with high-grade gliomas, 3-week hypofractionated radiotherapy (HFRT) is noninferior to standard long-course radiotherapy (LCRT). We…”
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The focal adhesion protein Hic-5 is highly expressed in the rat myometrium during late pregnancy and labour and co-localizes with FAK by Croke, Jenn M, Pike, Luke R G, MacPhee, Daniel J

“…Myometrial growth and remodeling of the cytoskeleton and focal adhesions during late pregnancy may be critical aspects of myometrial activation and thus…”
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Radiation and PD-1 inhibition: Favorable outcomes after brain-directed radiation by Pike, Luke R.G., Bang, Andrew, Ott, Patrick, Balboni, Tracy, Taylor, Allison, Catalano, Paul, Rawal, Bhupendra, Spektor, Alexander, Krishnan, Monica, Cagney, Daniel, Alexander, Brian, Aizer, Ayal A, Buchbinder, Elizabeth, Awad, Mark, Gandhi, Leena, Hodi, F. Stephen, Schoenfeld, Jonathan D

“…Patients with metastatic melanoma, renal cell carcinoma (RCC) and non-small cell lung cancer (NSCLC) are increasingly treated with immune checkpoint blockade…”
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Tyrosine Kinase Inhibitors With and Without Up-Front Stereotactic Radiosurgery for Brain Metastases From EGFR and ALK Oncogene-Driven Non-Small Cell Lung Cancer (TURBO-NSCLC) by Pike, Luke R G, Miao, Emily, Boe, Lillian A, Patil, Tejas, Imber, Brandon S, Myall, Nathaniel J, Pollom, Erqi L, Hui, Caressa, Qu, Vera, Langston, Jacob, Chiang, Veronica, Grant, Michael, Goldberg, Sarah B, Palmer, Joshua D, Prasad, Rahul N, Wang, Tony J C, Lee, Albert, Shu, Catherine A, Chen, Lanyi Nora, Thomas, Nicholas J, Braunstein, Steve E, Kavanagh, Brian D, Camidge, D Ross, Rusthoven, Chad G

“…Newer-generation tyrosine kinase inhibitors (TKIs) for non-small cell lung cancer (NSCLC) with epidermal growth factor receptor ( ) mutations and anaplastic…”
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Fractionated Proton Radiation Therapy and Hearing Preservation for Vestibular Schwannoma: Preliminary Analysis of a Prospective Phase 2 Clinical Trial by Saraf, Anurag, Pike, Luke R G, Franck, Kevin H, Horick, Nora K, Yeap, Beow Y, Fullerton, Barbara C, Wang, Irene S, Abazeed, Mohamed E, McKenna, Michael J, Mehan, William A, Plotkin, Scott R, Loeffler, Jay S, Shih, Helen A

“…Local management for vestibular schwannoma (VS) is associated with excellent local control with focus on preserving long-term serviceable hearing. Fractionated…”
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Optimal systemic treatment and real-world clinical application of ctDNA in patients with metastatic HER2-mutant lung cancer by Liu, Si-Yang, Erazo, Tatiana, Jee, Justin, Arfe, Andrea, Gupta, Avantika, Pike, Luke R.G., Santini, Fernando C., Daly, Bobby, Schoenfeld, Adam, Eichholz, Jordan, Johnson, Kaylie, Martinez, Andres, Sui, Jane, Riaz, Nadeem, Chang, Jason, Yang, Soo-Ryum, Travis, William, Arcila, Maria E., Guo, Jiannan, Gagne, Eric, Garg, Kavita, Baehner, Frederick, Lee, Nancy Y., Drilon, Alexander, Kris, Mark G., Scher, Howard I., Razavi, Pedram, Gomez, Daniel R., Jones, David R., Rudin, Charles M., Chandarlapaty, Sarat, Isbell, James M., Li, Bob T.

“…No definitive answers currently exist regarding optimal first-line therapy for HER2-mutant NSCLC. Access to rapid tissue sequencing is a major barrier to…”
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Clinicogenomic predictors of survival and intracranial progression after stereotactic radiosurgery for colorectal cancer brain metastases by Gui, Chengcheng, Walch, Henry S, Mueller, Kirin D, Boe, Lillian A, Ilica, A Turan, Strong, James, Eichholz, Jordan E, Yu, Kenny K H, Wilcox, Jessica A, Manca, Paolo, Yu, Yao, Yamada, Yoshiya, Imber, Brandon S, Maron, Steven B, Foote, Michael B, Yaeger, Rona, Schultz, Nikolaus, Pike, Luke R G

“…Brain metastases (BM) from colorectal cancer (CRC) are associated with dismal prognosis. When BM-directed therapy is considered, better methods are needed to…”
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40 Gray in 5 Fractions for Salvage Reirradiation of Spine Lesions Previously Treated With Stereotactic Body Radiotherapy by Moore, Assaf, Zhang, Zhigang, Fei, Teng, Zhang, Lei, Accomando, Laura, Schmitt, Adam M, Higginson, Daniel S, Mueller, Boris A, Zinovoy, Melissa, Gelblum, Daphna Y, Yerramilli, Divya, Xu, Amy J, Brennan, Victoria S, Guttmann, David M, Grossman, Craig E, Dover, Laura L, Shaverdian, Narek, Pike, Luke R G, Cuaron, John J, Dreyfuss, Alexandra, Lis, Eric, Barzilai, Ori, Bilsky, Mark H, Yamada, Yoshiya

“…A retrospective single-center analysis of the safety and efficacy of reirradiation to 40 Gy in 5 fractions (reSBRT) in patients previously treated with…”
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Outcomes of HPV-Associated Squamous Cell Carcinoma of the Head and Neck: Impact of Race and Socioeconomic Status by Pike, Luke R G, Royce, Trevor J, Mahal, Amandeep R, Kim, Daniel W, Hwang, William L, Mahal, Brandon A, Sanford, Nina N

“…Socioeconomic factors affecting outcomes of HPV-associated squamous cell carcinoma of the head and neck (SCCHN) are poorly characterized. A custom SEER…”
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