Search Results - "Pike, B.R."

Temporal Profile of Apoptotic-like Changes in Neurons and Astrocytes Following Controlled Cortical Impact Injury in the Rat by Newcomb, J.K., Zhao, X., Pike, B.R., Hayes, R.L.

“…Apoptotic cell death has been observed in both neurodegenerative diseases and acute neurological traumas such as ischemia, spinal cord injury, and traumatic…”
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Effects of injury severity on regional and temporal mRNA expression levels of calpains and caspases after traumatic brain injury in rats by Ringger, N C, Tolentino, P J, McKinsey, D M, Pike, B R, Wang, K K W, Hayes, R L

“…Despite a preponderance of studies demonstrating gene expression and/or enzymatic activation of calpain and caspase proteases after traumatic brain injury…”
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Protective effects of moderate hypothermia on behavioral deficits but not necrotic cavitation following cortical impact injury in the rat by Dixon, C E, Markgraf, C G, Angileri, F, Pike, B R, Wolfson, B, Newcomb, J K, Bismar, M M, Blanco, A J, Clifton, G L, Hayes, R L

“…A number of experimental studies have reported that moderate hypothermia can produce significant protection against behavioral deficits and/or…”
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Systemic administration of a calpain inhibitor reduces behavioral deficits and blood-brain barrier permeability changes after experimental subarachnoid hemorrhage in the rat by Germanò, A, Costa, C, DeFord, S M, Angileri, F F, Arcadi, F, Pike, B R, Bramanti, P, Bausano, B, Zhao, X, Day, A L, Anderson, D K, Hayes, R L

“…Increases in intracellular calcium and subsequent activation of calcium-activated proteases (e.g., calpains) may play a critical role in central nervous system…”
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pH dependency of μ-calpain and m-calpain activity assayed by casein zymography following traumatic brain injury in the rat by Zhao, X, Newcomb, J.K, Posmantur, R.M, Wang, K.K.W, Pike, B.R, Hayes, R.L

“…Studies employing casein zymographic assays analyzed the effects of varying pH (from pH 6.8 to pH 8.0) on changes in μ-calpain and m-calpain activity in naive,…”
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Chronic post-injury administration of BIBN 99, a selective muscarinic M2 receptor antagonist, attenuates cognitive impairment following traumatic brain injury in the rat by Pike, B.R, Hamm, R.J, O'Dell, D.M, Temple, M.D, Lyeth, B.G

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Activation of phosphatidylinositol 3-kinase by brain-derived neurotrophic factor gene transfection in septo-hippocampal cultures by Qiu, Y.H., Zhao, X., Hayes, R.L., Perez-Polo, J.R., Pike, B.R., Huang, L., Clifton, G.L., Yang, K.

“…Brain‐derived neurotrophic factor (BDNF) has therapeutic potential for treatment of the injured central nervous system. BDNF induces both differentiation and…”
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