Search Results - "Pikal, M J"

A procedure to optimize scale-up for the primary drying phase of lyophilization by Kramer, T, Kremer, D M, Pikal, M J, Petre, W J, Shalaev, E Y, Gatlin, L A

“…This article describes a procedure to facilitate scale-up for the primary drying phase of lyophilization using a combination of empirical testing and numerical…”
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Rational design of stable lyophilized protein formulations : Some practical advice by CARPENTER, J. F, PIKAL, M. J, CHANG, B. S, RANDOLPH, T. W

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Effect of initial buffer composition on pH changes during far-from-equilibrium freezing of sodium phosphate buffer solutions by GOMEZ, Gerardo, PIKAL, Michael J, RODRIGUEZ-HORNEDO, Nair

“…This study aims to assess the pH changes induced by salt precipitation during far-from-equilibrium freezing of sodium phosphate buffers as a function of buffer…”
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The nonsteady state modeling of freeze drying: In-process product temperature and moisture content mapping and pharmaceutical product quality applications by PIKAL, M. J, CARDON, S, BHUGRA, Chandan, JAMEEL, F, RAMBHATLA, S, MASCARENHAS, W. J, AKAY, H. U

“…Theoretical models of the freeze-drying process are potentially useful to guide the design of a freeze-drying process as well as to obtain information not…”
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CdSe quantum dots synthesized by laser ablation in water and their photovoltaic applications by Horoz, Sabit, Lu, Liyou, Dai, Qilin, Chen, Jiajun, Yakami, Baichhabi, Pikal, J. M., Wang, Wenyong, Tang, Jinke

“…CdSe quantum dots (QDs) have been prepared by a facile and clean synthesis method––laser ablation in water. The structural and luminescent properties of the…”
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Interpretation of relaxation time constants for amorphous pharmaceutical systems by Shamblin, S L, Hancock, B C, Dupuis, Y, Pikal, M J

“…The molecular mobility of amorphous pharmaceutical materials is known to be a key factor in determining their stability, reactivity, and physicochemical…”
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Carrier distribution, gain, and lasing in 1.3-μm InAs-InGaAs quantum-dot lasers by DIKSHIT, A. A, PIKAL, J. M

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The stability of insulin in crystalline and amorphous solids : Observation of greater stability for the amorphous form by PIKAL, M. J, RIGSBEE, D. R

“…Generalizations based upon behavior of small molecules have established that a crystalline solid is generally much more stable toward chemical degradation than…”
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A computational model for finite element analysis of the freeze-drying process by Mascarenhas, W.J., Akay, H.U., Pikal, M.J.

“…A brief overview of the freeze-drying process is given, followed by presentation of the governing equations and the finite element formulation in…”
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The role of electroosmotic flow in transdermal iontophoresis by Pikal, Michael J.

“…Iontophoresis enhances transdermal drug delivery by three mechanisms: (a) the ion-electric field interaction provides an additional force which drives ions…”
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Increased monomolecular recombination in MOCVD grown 1.3- mu m InGaAsN-GaAsP-GaAs QW lasers from carrier lifetime measurements by Anton, O, Menoni, C S, Yeh, J Y, Mawst, L J, Pikal, J M, Tansu, N

“…The recombination lifetime of metal-organic chemical vapor deposition grown InGaAsN-GaAsP-GaAs lasers with nitrogen content of 0% and 0.5% has been…”
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A pragmatic test of a simple calorimetric method for determining the fragility of some amorphous pharmaceutical materials by HANCOCK, B. C, DALTON, C. R, PIKAL, M. J, SHAMBLIN, S. L

“…To evaluate a simple calorimetric method for estimating the fragility of amorphous pharmaceutical materials from the width of the glass transition region. The…”
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The effects of formulation variables on the stability of freeze-dried human growth hormone by PIKAL, M. J, DELLERMAN, K. M, ROY, M. L, RIGGIN, R. M

“…Formulation often has a dramatic effect on degradation of proteins during the freeze-drying process as well as impacting on the "shelf-life" stability of the…”
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Small-signal response of 1.3-μm InAsP-InGaAsP quantum-well laser diodes obtained with a terahertz-bandwidth frequency comb by ANTON, Ovidio H, PATEL, Dinesh, VASCHENKO, Georgiy, MENONI, Carmen S, PIKAL, J. M

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Mass and heat transfer in vial freeze-drying of pharmaceuticals: role of the vial by Pikal, M J, Roy, M L, Shah, S

“…Flow of water vapor is impeded by three barriers or resistances: resistance of the dried-product layer, resistance of the semistoppered vial, and resistance of…”
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A spectroscopic investigation of hydrogen bond patterns in crystalline and amorphous phases in dihydropyridine calcium channel blockers by TANG, Xiaolin Charlie, PIKAL, Michael J, TAYLOR, Lynne S

“…To gain insight into the molecular structure of amorphous compounds by investigating hydrogen bonding patterns and strength in a series of structurally related…”
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Carrier lifetime and recombination in long-wavelength quantum-well lasers by Pikal, J.M., Menoni, C.S., Temkin, H., Thiagarajan, P., Robinson, G.Y.

“…We present a novel analysis for correcting the measured differential carrier lifetime to account for carrier population in both the barrier and separate…”
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Carrier Recombination Dynamics Investigations of Strain-Compensated InGaAsN Quantum Wells by Lifang Xu, Patel, D., Menoni, C. S., Pikal, J. M., Jeng-Ya Yeh, Huang, J. Y. T., Mawst, L. J., Tansu, N.

“…The time evolution of the photoluminescence (PL) of 1300-nm emitting InGaAsN/ GaAs/GaAsP strain-compensated single quantum well (QW) in the temperature range…”
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A method for the rapid estimation of sublimation rates of organic compounds at standard temperature and pressure by Tesconi, M, Pikal, M J, Yalkowsky, S H

“…A method for the rapid estimation of the sublimation rates of organic compounds at standard temperature and pressure (STP; 298 K and 101.3 kPa, respectively)…”
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The effect of temperature on hydrogen bonding in crystalline and amorphous phases in dihydropyrine calcium channel blockers by TANG, Xiaolin Charlie, PIKAL, Michael J, TAYLOR, Lynne S

“…To investigate the effect of temperature on hydrogen bonding in a series of structurally related amorphous and crystalline compounds to gain a better…”
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