Search Results - "Pijoan, Albert Puig"
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Underdiagnosis of Unilateral Spatial Neglect in stroke unit
Published in Acta neurologica Scandinavica (01-11-2018)“…Objectives Unilateral spatial neglect (USN) is the incapacity to respond to stimuli presented opposite to a dysfunctional cerebral hemisphere. It is usually…”
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Plasma and CSF biomarkers in a memory clinic: Head‐to‐head comparison of phosphorylated tau immunoassays
Published in Alzheimer's & dementia (01-05-2023)“…Introduction Direct comparisons of the main blood phosphorylated tau immunoassays in memory clinic populations are needed to understand possible differences…”
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Effects of COVID-19 Pandemic Confinement in Patients With Cognitive Impairment
Published in Frontiers in neurology (24-11-2020)“…State of emergency caused by COVID-19 pandemic and subsequent lockdown hit Spain on 14th March 2020 and lasted until 21st June 2020. Social isolation measures…”
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Blood‐brain barrier integrity impacts the use of plasma amyloid‐β as a proxy of brain amyloid‐β pathology
Published in Alzheimer's & dementia (01-09-2023)“…INTRODUCTION Amyloid‐β (Aβ) and tau can be quantified in blood. However, biological factors can influence the levels of brain‐derived proteins in the blood…”
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Cognitive function and neuroimaging correlates in a subjective cognitive decline population within a multimodal intervention supplemented with green tea extract (PENSA Study): Preliminary results of a voxel‐based morphometry study
Published in Alzheimer's & dementia (01-12-2021)“…Background Multicomponent interventions including diet, physical activity and cognitive training have shown great potential to prevent cognitive decline in…”
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PENSA study for the prevention of cognitive decline in APOE‐ɛ4 carriers with subjective cognitive decline: Baseline preliminary demographic and neuropsychological description of the study population
Published in Alzheimer's & dementia (01-12-2021)“…Background In the absence of effective treatments to reverse cognitive deterioration related to Alzheimer's disease (AD), nonpharmacological secondary…”
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Time‐encoded ASL reveals lower cerebral blood flow in the early AD continuum
Published in Alzheimer's & dementia (01-08-2024)“…INTRODUCTION Cerebral blood flow (CBF) is reduced in cognitively impaired (CI) Alzheimer's disease (AD) patients. We checked the sensitivity of time‐encoded…”
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Risk of cognitive decline progression is associated to increased blood‐brain‐barrier permeability: A longitudinal study in a memory unit clinical cohort
Published in Alzheimer's & dementia (01-01-2024)“…INTRODUCTION This study examined the relationship between blood‐brain‐barrier permeability (BBBp), measured by cerebrospinal fluid/serum albumin ratio (QAlb),…”
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A blood‐based multi‐pathway biomarker assay for early detection and staging of Alzheimer's disease across ethnic groups
Published in Alzheimer's & dementia (01-03-2024)“…INTRODUCTION Existing blood‐based biomarkers for Alzheimer's disease (AD) mainly focus on its pathological features. However, studies on blood‐based biomarkers…”
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Blood Biomarkers of Alzheimer's Disease and Cognition: A Literature Review
Published in Biomolecules (Basel, Switzerland) (01-01-2024)“…Recent advances in blood-based biomarkers of Alzheimer's Disease (AD) show great promise for clinical applications, offering a less invasive alternative to…”
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Clinical performance and head-to-head comparison of CSF p-tau235 with p-tau181, p-tau217 and p-tau231 in two memory clinic cohorts
Published in Alzheimer's research & therapy (10-03-2023)“…Cerebrospinal fluid (CSF) p-tau235 is a novel biomarker highly specific of Alzheimer's disease (AD). However, CSF p-tau235 has only been studied in…”
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Medical help-seeking intentions among patients with early Alzheimer's disease
Published in Frontiers in psychiatry (19-12-2023)“…Limited information is available on the active process of seeking medical help in patients with Alzheimer's disease (AD) at early stages. The aim of this study…”
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The antigen-binding fragment of human gamma immunoglobulin prevents amyloid β-peptide folding into β-sheet to form oligomers
Published in Oncotarget (20-06-2017)“…The amyloid beta-peptide (Aβ) plays a leading role in Alzheimer's disease (AD) physiopathology. Even though monomeric forms of Aβ are harmless to cells, Aβ can…”
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Blood‐brain barrier permeability and risk of conversion to dementia in patients with mild cognitive impairment
Published in Alzheimer's & dementia (01-12-2023)“…Background Cardiovascular risk factors (CVRF) have been associated with an increased risk of cognitive decline and dementia. Increase of blood‐brain barrier…”
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Insulin resistance, vascular dysfunction and inflammation biomarkers associations with an increased CAIDE risk score in APOE‐ε4 carriers with subjective cognitive decline from the PENSA study
Published in Alzheimer's & dementia (01-12-2023)“…Background The CAIDE (Cardiovascular Risk Factors –CVRF‐, Aging, and Incidence of Dementia) Dementia Risk Score is a validated tool to predict late‐life…”
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Time‐encoded ASL shows higher sensitivity to detect cerebral blood flow reductions in AD
Published in Alzheimer's & dementia (01-12-2023)“…Background Pseudo continuous arterial spin labelling (pcASL) is an MRI technique to quantify cerebral blood flow (CBF). Time encoded ASL (te‐ASL) is a multiple…”
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Prevention of cognitive decline in subjective cognitive decline APOE‐ε4 carriers after Epigallocatechin gallate and a multimodal intervention, the PENSA study: 1‐year follow‐up results of the randomized controlled trial
Published in Alzheimer's & dementia (01-12-2023)“…Background Preventive approaches such as lifestyle interventions targeting multiple Alzheimer’s disease (AD) risk or preventive factors are effective…”
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Usefulness of R2 maps to detect GM changes in AD continuum: a pilot study
Published in Alzheimer's & dementia (01-12-2023)“…Background MRI multi‐echo sequences can be used to compute quantitative R2 maps (1/T2). This pilot study aimed to determine whether R2 maps might offer…”
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Shared Proteins and Pathways of Cardiovascular and Cognitive Diseases: Relation to Vascular Cognitive Impairment
Published in Journal of proteome research (02-02-2024)“…One of the primary goals of systems medicine is the detection of putative proteins and pathways involved in disease progression and pathological phenotypes…”
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PENSA study for the prevention of cognitive decline in APOE‐ɛ4 carriers with subjective cognitive decline: Description of baseline demographic and neuropsychological data of the study population
Published in Alzheimer's & dementia (01-06-2023)“…Background Alzheimer’s disease (AD) is a multifactorial disorder likely caused by a complex interplay of different pathological processes that are influenced…”
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