Search Results - "Pihán, Philippe"

BCL-2 family: integrating stress responses at the ER to control cell demise by Pihán, Philippe, Carreras-Sureda, Amado, Hetz, Claudio

“…In the last decade, the endoplasmic reticulum (ER) has emerged as a central organelle regulating the core mitochondrial apoptosis pathway. At the ER membrane,…”
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Calcium signaling at the endoplasmic reticulum: fine-tuning stress responses by Carreras-Sureda, Amado, Pihán, Philippe, Hetz, Claudio

“…[Display omitted] Endoplasmic reticulum (ER) calcium signaling is implicated in a myriad of coordinated cellular processes. The ER calcium content is tightly…”
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The UPRosome - decoding novel biological outputs of IRE1α function by Urra, Hery, Pihán, Philippe, Hetz, Claudio

“…Different perturbations alter the function of the endoplasmic reticulum (ER), resulting in the accumulation of misfolded proteins in its lumen, a condition…”
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Calcium signaling in lysosome-dependent cell death by Milani, Mateus, Pihán, Philippe, Hetz, Claudio

“…•Calcium is a crucial messenger of intracellular and extracellular signals.•Lysosome-dependent cell death is a specific type of cell death mediated by…”
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Getting intimate: Lysosomes and ER rendezvous to control autophagy by Pihán, Philippe, Hetz, Claudio

“…The endoplasmic reticulum (ER) is the source of lysosomal calcium. The finding that the protein TMBIM6 –a putative ER calcium channel and cell death regulator…”
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The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics by Carreras-Sureda, Amado, Pihán, Philippe, Hetz, Claudio

“…Endoplasmic reticulum (ER) to mitochondria communication has emerged in recent years as a signaling hub regulating cellular physiology with a relevant…”
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Proapoptotic RECS1: a requisite gateway to lysosomal dysfunction and death by Pihán, Philippe, Milani, Mateus, Hetz, Claudio

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Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics by Carreras-Sureda, Amado, Jaña, Fabián, Urra, Hery, Durand, Sylvere, Mortenson, David E., Sagredo, Alfredo, Bustos, Galdo, Hazari, Younis, Ramos-Fernández, Eva, Sassano, Maria L., Pihán, Philippe, van Vliet, Alexander R., González-Quiroz, Matías, Torres, Angie K., Tapia-Rojas, Cheril, Kerkhofs, Martijn, Vicente, Rubén, Kaufman, Randal J., Inestrosa, Nibaldo C., Gonzalez-Billault, Christian, Wiseman, R. Luke, Agostinis, Patrizia, Bultynck, Geert, Court, Felipe A., Kroemer, Guido, Cárdenas, J. César, Hetz, Claudio

“…Mitochondria-associated membranes (MAMs) are central microdomains that fine-tune bioenergetics by the local transfer of calcium from the endoplasmic reticulum…”
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Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response by Dufey, Estefanie, Bravo-San Pedro, José Manuel, Eggers, Cristian, González-Quiroz, Matías, Urra, Hery, Sagredo, Alfredo I., Sepulveda, Denisse, Pihán, Philippe, Carreras-Sureda, Amado, Hazari, Younis, Sagredo, Eduardo A., Gutierrez, Daniela, Valls, Cristian, Papaioannou, Alexandra, Acosta-Alvear, Diego, Campos, Gisela, Domingos, Pedro M., Pedeux, Rémy, Chevet, Eric, Alvarez, Alejandra, Godoy, Patricio, Walter, Peter, Glavic, Alvaro, Kroemer, Guido, Hetz, Claudio

“…The molecular connections between homeostatic systems that maintain both genome integrity and proteostasis are poorly understood. Here we identify the…”
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Role of the unfolded protein response in organ physiology: Lessons from mouse models by Cornejo, Víctor Hugo, Pihán, Philippe, Vidal, René Luis, Hetz, Claudio

“…The endoplasmic reticulum (ER) is a key subcellular compartment involved in the folding and maturation of around one‐third of the total proteome. Accumulation…”
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Simultaneous determination of intraluminal lysosomal calcium and pH by dextran-conjugated fluorescent dyes by Pihán, Philippe, Nunes-Hasler, Paula, Demaurex, Nicolas, Hetz, Claudio

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A phenolic-rich extract from Ugni molinae berries reduces abnormal protein aggregation in a cellular model of Huntington's disease by Pérez-Arancibia, Rodrigo, Ordoñez, Jose Luis, Rivas, Alexis, Pihán, Philippe, Sagredo, Alfredo, Ahumada, Ulises, Barriga, Andrés, Seguel, Ivette, Cárdenas, César, Vidal, Rene L, Hetz, Claudio, Delporte, Carla

“…Accumulation of misfolded proteins in the brain is a common hallmark of most age-related neurodegenerative diseases. Previous studies from our group identified…”
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Mitochondria-associated niches in health and disease by Milani, Mateus, Pihán, Philippe, Hetz, Claudio

“…The appreciation of the importance of interorganelle contacts has steadily increased over the past decades. Advances in imaging, molecular biology and…”
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Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1 by Pihán, Philippe, Lisbona, Fernanda, Borgonovo, Janina, Edwards-Jorquera, Sandra, Nunes-Hasler, Paula, Castillo, Karen, Kepp, Oliver, Urra, Hery, Saarnio, Suvi, Vihinen, Helena, Carreras-Sureda, Amado, Forveille, Sabrina, Sauvat, Allan, De Giorgis, Daniela, Pupo, Amaury, Rodríguez, Diego A, Quarato, Giovanni, Sagredo, Alfredo, Lourido, Fernanda, Letai, Anthony, Latorre, Ramon, Kroemer, Guido, Demaurex, Nicolas, Jokitalo, Eija, Concha, Miguel L, Glavic, Álvaro, Green, Douglas R, Hetz, Claudio

“…Programmed cell death is regulated by the balance between activating and inhibitory signals. Here, we have identified RECS1 (responsive to centrifugal force…”
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The Ric-8B Gene Is Highly Expressed in Proliferating Preosteoblastic Cells and Downregulated during Osteoblast Differentiation in a SWI/SNF- and C/EBPβ-Mediated Manner by Grandy, Rodrigo, Sepulveda, Hugo, Aguilar, Rodrigo, Pihan, Philippe, Henriquez, Berta, Olate, Juan, Montecino, Martin

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Role of the unfolded protein response in organ physiology: Lessons from mouse models: Physiological Function of UPR in Organs and Tissues by Cornejo, Víctor Hugo, Pihán, Philippe, Vidal, René Luis, Hetz, Claudio

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Publisher Correction: Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics by Carreras-Sureda, Amado, Jaña, Fabián, Urra, Hery, Durand, Sylvere, Mortenson, David E., Sagredo, Alfredo, Bustos, Galdo, Hazari, Younis, Ramos-Fernández, Eva, Sassano, Maria L., Pihán, Philippe, van Vliet, Alexander R., González-Quiroz, Matías, Torres, Angie K., Tapia-Rojas, Cheril, Kerkhofs, Martijn, Vicente, Rubén, Kaufman, Randal J., Inestrosa, Nibaldo C., Gonzalez-Billault, Christian, Wiseman, R. Luke, Agostinis, Patrizia, Bultynck, Geert, Court, Felipe A., Kroemer, Guido, Cárdenas, J. César, Hetz, Claudio

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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A Functional N-terminal Domain in C/EBPβ-LAP is Required for Interacting with SWI/SNF and to Repress Ric-8B Gene Transcription in Osteoblasts by Aguilar, Rodrigo, Grandy, Rodrigo, Meza, Daniel, Sepulveda, Hugo, Pihan, Philippe, van Wijnen, Andre J., Lian, Jane B., Stein, Gary S., Stein, Janet L., Montecino, Martin

“…ABSTRACT The chromatin remodeling complex SWI/SNF and the transcription factor C/EBPβ play critical roles in osteoblastic cells as they jointly control…”
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A Functional N-terminal Domain in C/EBP[beta]-LAP is Required for Interacting with SWI/SNF and to Repress Ric-8B Gene Transcription in Osteoblasts by Aguilar, Rodrigo, Grandy, Rodrigo, Meza, Daniel, Sepulveda, Hugo, Pihan, Philippe, van Wijnen, Andre J, Lian, Jane B, Stein, Gary S, Stein, Janet L, Montecino, Martin

“…The chromatin remodeling complex SWI/SNF and the transcription factor C/EBP[beta] play critical roles in osteoblastic cells as they jointly control…”
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The Ric-8B gene is highly expressed in proliferating preosteoblastic cells and downregulated during osteoblast differentiation in a SWI/SNF- and C/EBPbeta-mediated manner by Grandy, Rodrigo, Sepulveda, Hugo, Aguilar, Rodrigo, Pihan, Philippe, Henriquez, Berta, Olate, Juan, Montecino, Martin

“…The Ric-8 gene encodes a guanine exchange factor (GEF) that modulates G protein-mediated signaling, exhibiting a relevant role during regulation of cell…”
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