Search Results - "Pignolet, Beatrice"

Increased levels of circulating soluble CD226 in multiple sclerosis by Kari, Saniya, Bucciarelli, Florence, Angles, Thibault, Oster, Anne-Cecile, Cauboue, Pauline, Laviolette, Karl, Mougenot, Madeline, Morandi, Elena, Bernard, Isabelle, Pignolet, Beatrice, Bost, Chloé, Thomas, Joelle, Nogueira, Leonor, Saoudi, Abdelhadi, Liblau, Roland, Astier, Anne L

“…Background: The glycoprotein CD226 plays a key role in regulating immune cell function. Soluble CD226 (sCD226) is increased in sera of patients with several…”
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Immunopathogenesis of paraneoplastic neurological syndromes associated with anti-Hu antibodies: A beneficial antitumor immune response going awry by Pignolet, Béatrice SL, Gebauer, Christina MT, Liblau, Roland S

“…Paraneoplastic neurological disorders (PNDs) are syndromes that develop in cancer patients when an efficient antitumor immune response, directed against…”
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Prospective validation of the PML risk biomarker L-Selectin and influence of natalizumab extended intervals by Schwab, Nicholas, Schneider-Hohendorf, Tilman, Pignolet, Béatrice, Bucciarelli, Florence, Scandella, Lise, Ciron, Jonathan, Biotti, Damien, Lebrun-Frenay, Christine, Mathey, Guillaume, Clavelou, Pierre, Pelletier, Jean, Ostkamp, Patrick, Meinl, Ingrid, Windhagen, Susanne, Klotz, Luisa, Gross, Catharina C, Meuth, Sven G, Deisenhammer, Florian, Brassat, David, Wiendl, Heinz

“…Low l-selectin (CD62L) on CD4+ T cells after cryopreservation has been introduced in 2013 as a risk biomarker for the development of progressive multifocal…”
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Real-World Effectiveness of Natalizumab Extended Interval Dosing in a French Cohort by Pelle, Juliette, Briant, Anais R., Branger, Pierre, Derache, Nathalie, Arnaud, Charlotte, Lebrun-Frenay, Christine, Cohen, Mikael, Mondot, Lydiane, De Seze, Jerome, Bigaut, Kevin, Collongues, Nicolas, Kremer, Laurent, Ricard, Damien, Bompaire, Flavie, Ohlmann, Charlotte, Sallansonnet-Froment, Magali, Ciron, Jonathan, Biotti, Damien, Pignolet, Beatrice, Parienti, Jean-Jacques, Defer, Gilles

“…Introduction Natalizumab, a therapy for relapsing–remitting multiple sclerosis (RRMS), is associated with a risk of progressive multifocal leukoencephalopathy…”
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DNA Methylation in the Anti‐Mullerian Hormone Gene and the Risk of Disease Activity in Multiple Sclerosis by Giordano, Antonino, Pignolet, Béatrice, Mascia, Elisabetta, Clarelli, Ferdinando, Sorosina, Melissa, Misra, Kaalindi, Bucciarelli, Florence, Ferrè, Laura, Moiola, Lucia, Liblau, Roland, Filippi, Massimo, Esposito, Federica

“…Objective Multiple sclerosis (MS) has a complex pathobiology, with genetic and environmental factors being crucial players. Understanding the mechanisms…”
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CTLA4 blockade elicits paraneoplastic neurological disease in a mouse model by Yshii, Lidia M, Gebauer, Christina M, Pignolet, Béatrice, Mauré, Emilie, Quériault, Clémence, Pierau, Mandy, Saito, Hiromitsu, Suzuki, Noboru, Brunner-Weinzierl, Monika, Bauer, Jan, Liblau, Roland

“…CTLA4 is an inhibitory regulator of immune responses. Therapeutic CTLA4 blockade enhances T cell responses against cancer and provides striking clinical…”
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Author response: Prospective validation of the PML risk biomarker L-selectin and influence of natalizumab extended intervals by Schwab, Nicholas, Schneider-Hohendorf, Tilman, Pignolet, Béatrice, Brassat, David, Wiendl, Heinz

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Broader Epstein-Barr virus-specific T cell receptor repertoire in patients with multiple sclerosis by Schneider-Hohendorf, Tilman, Gerdes, Lisa Ann, Pignolet, Béatrice, Gittelman, Rachel, Ostkamp, Patrick, Rubelt, Florian, Raposo, Catarina, Tackenberg, Björn, Riepenhausen, Marianne, Janoschka, Claudia, Wünsch, Christian, Bucciarelli, Florence, Flierl-Hecht, Andrea, Beltrán, Eduardo, Kümpfel, Tania, Anslinger, Katja, Gross, Catharina C, Chapman, Heidi, Kaplan, Ian, Brassat, David, Wekerle, Hartmut, Kerschensteiner, Martin, Klotz, Luisa, Lünemann, Jan D, Hohlfeld, Reinhard, Liblau, Roland, Wiendl, Heinz, Schwab, Nicholas

“…Epstein-Barr virus (EBV) infection precedes multiple sclerosis (MS) pathology and cross-reactive antibodies might link EBV infection to CNS autoimmunity. As an…”
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CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice by Bernard-Valnet, Raphaël, Yshii, Lidia, Quériault, Clémence, Nguyen, Xuan-Hung, Arthaud, Sébastien, Rodrigues, Magda, Canivet, Astrid, Morel, Anne-Laure, Matthys, Arthur, Bauer, Jan, Pignolet, Béatrice, Dauvilliers, Yves, Peyron, Christelle, Liblau, Roland S.

“…Narcolepsy with cataplexy is a rare and severe sleep disorder caused by the destruction of orexinergic neurons in the lateral hypothalamus. The genetic and…”
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BEST-MS: A prospective head-to-head comparative study of natalizumab and fingolimod in active relapsing MS by Cohen, Mikael, Mondot, Lydiane, Bucciarelli, Florence, Pignolet, Béatrice, Laplaud, David-Axel, Wiertlewski, Sandrine, Brochet, Bruno, Ruet, Aurélie, Defer, Gilles, Derache, Nathalie, Vermersch, Patrick, Zephir, Hélène, Debouverie, Marc, Mathey, Guillaume, Berger, Eric, Cappé, Chrystelle, Labauge, Pierre, Carra, Clarisse, De Seze, Jérôme, Bigaut, Kevin, Brassat, David, Lebrun-Frenay, Christine

“…Background: There are few head-to-head studies to compare highly active treatments in multiple sclerosis (MS) Objective: The aim of this study was to compare…”
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Vitamin D affects the risk of disease activity in multiple sclerosis by Giordano, Antonino, Clarelli, Ferdinando, Pignolet, Béatrice, Mascia, Elisabetta, Sorosina, Melissa, Misra, Kaalindi, Ferrè, Laura, Bucciarelli, Florence, Manouchehrinia, Ali, Moiola, Lucia, Martinelli, Vittorio, Rocca, Maria A, Liblau, Roland, Filippi, Massimo, Esposito, Federica

“…BackgroundVitamin D (VitD) affects the risk of multiple sclerosis (MS), but the impact on disease activity is controversial. We assessed whether VitD is…”
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CD4+ and CD8+ T cells are both needed to induce paraneoplastic neurological disease in a mouse model by Gebauer, Christina, Pignolet, Béatrice, Yshii, Lidia, Mauré, Emilie, Bauer, Jan, Liblau, Roland

“…Paraneoplastic neurological disorders (PNDs) are rare human autoimmune diseases that mostly affect the central nervous system (CNS). They are triggered by an…”
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EVER proteins, key elements of the natural anti-human papillomavirus barrier, are regulated upon T-cell activation by Lazarczyk, Maciej, Dalard, Cécile, Hayder, Myriam, Dupre, Loïc, Pignolet, Béatrice, Majewski, Slawomir, Vuillier, Francoise, Favre, Michel, Liblau, Roland S

“…Human papillomaviruses (HPV) cause a variety of mucosal and skin lesions ranging from benign proliferations to invasive carcinomas. The clinical manifestations…”
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NFL pattern in progressive Multiple Sclerosis cohort under MD1003 treatment (P4.2-008) by Pignolet, Beatrice, Ammoscato, Francesca, Ciron, Jonathan, Bucciarelli, Florence, Scandella, Lise, Biotti, Damien, Lerebours, Fleur, Dorcet, Guillaume, Rabadeux, Céline, Freitas, Noellie, Bonneville, Fabrice, Gnanapavan, Sharmilee, Brassat, David

“…Abstract only…”
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PML risk stratification using anti-JCV antibody index and L-selectin by Schwab, Nicholas, Schneider-Hohendorf, Tilman, Pignolet, Béatrice, Spadaro, Michela, Görlich, Dennis, Meinl, Ingrid, Windhagen, Susanne, Tackenberg, Björn, Breuer, Johanna, Cantó, Ester, Kümpfel, Tania, Hohlfeld, Reinhard, Siffrin, Volker, Luessi, Felix, Posevitz-Fejfár, Anita, Montalban, Xavier, Meuth, Sven G, Zipp, Frauke, Gold, Ralf, Du Pasquier, Renaud A, Kleinschnitz, Christoph, Jacobi, Annett, Comabella, Manuel, Bertolotto, Antonio, Brassat, David, Wiendl, Heinz

“…Background: Natalizumab treatment is associated with progressive multifocal leukoencephalopathy (PML) development. Treatment duration, prior immunosuppressant…”
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Therapy with natalizumab is associated with high JCV seroconversion and rising JCV index values by Schwab, Nicholas, Schneider-Hohendorf, Tilman, Pignolet, Béatrice, Breuer, Johanna, Gross, Catharina C, Göbel, Kerstin, Brassat, David, Wiendl, Heinz

“…OBJECTIVE:The aim of the study was to analyze John Cunningham virus (JCV) serology in natalizumab-treated patients over time and assess whether they are…”
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Matrix metalloproteinase 9 is decreased in natalizumab‐treated multiple sclerosis patients at risk for progressive multifocal leukoencephalopathy by Fissolo, Nicolas, Pignolet, Béatrice, Matute‐Blanch, Clara, Triviño, Juan Carlos, Miró, Berta, Mota, Miriam, Perez‐Hoyos, Santiago, Sanchez, Alex, Vermersch, Patrick, Ruet, Aurélie, Sèze, Jérôme, Labauge, Pierre, Vukusic, Sandra, Papeix, Caroline, Almoyna, Laurent, Tourbah, Ayman, Clavelou, Pierre, Moreau, Thibault, Pelletier, Jean, Lebrun‐Frenay, Christine, Montalban, Xavier, Brassat, David, Comabella, Manuel

“…Objective To identify biomarkers associated with the development of progressive multifocal leukoencephalopathy (PML) in multiple sclerosis (MS) patients…”
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IFN-γ is a therapeutic target in paraneoplastic cerebellar degeneration by Yshii, Lidia, Pignolet, Béatrice, Mauré, Emilie, Pierau, Mandy, Brunner-Weinzierl, Monika, Hartley, Oliver, Bauer, Jan, Liblau, Roland

“…Paraneoplastic neurological disorders result from an autoimmune response against neural self-antigens that are ectopically expressed in neoplastic cells. In…”
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Cutting edge: neuronal recognition by CD8 T cells elicits central diabetes insipidus by Scheikl, Tanja, Pignolet, Béatrice, Dalard, Cécile, Desbois, Sabine, Raison, Danièle, Yamazaki, Masanori, Saoudi, Abdelhadi, Bauer, Jan, Lassmann, Hans, Hardin-Pouzet, Hélène, Liblau, Roland S

“…An increasing number of neurologic diseases is associated with autoimmunity. The immune effectors contributing to the pathogenesis of such diseases are often…”
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Transgenic mouse models of multiple sclerosis by Scheikl, Tanja, Pignolet, Béatrice, Mars, Lennart T., Liblau, Roland S.

“…Multiple sclerosis (MS) is an inflammatory demyelinating disease affecting the central nervous system (CNS) and a frequent cause of neurological disability in…”
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