Search Results - "Pietz, Mark A"

Development of a Leuckart–Wallach Reaction in Flow for the Synthesis of Abemaciclib by Frederick, Michael O, Pietz, Mark A, Kjell, Douglas P, Richey, Rachel N, Tharp, Gregg A, Touge, Taichiro, Yokoyama, Naota, Kida, Michio, Matsuo, Toshiyasu

“…The development of a route for a key building block in the synthesis of abemaciclib is described. The route proceeds through a Leuckart–Wallach reductive…”
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Use of Modeling and Process Analytical Technologies in the Design of a Catalytic Amination Reaction: Understanding Oxygen Sensitivity at the Lab and Manufacturing Scales by Merritt, Jeremy M, Buser, Jonas Y, Campbell, Alison N, Fennell, Jared W, Kallman, Neil J, Koenig, Thomas M, Moursy, Hossam, Pietz, Mark A, Scully, Norma, Singh, Utpal K

“…A mechanistic approach was undertaken to understand the oxygen sensitivity of a Pd-catalyzed amination reaction used in the synthesis of an active…”
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Development of an Improved Route for the Synthesis of an Abemaciclib Intermediate by Carroll, Michael P, Moloney, Harold, Gowran, Olivia, O’Connor, Aoibheann, Wilson, Eoin M, Murray, Michael M, Pietz, Mark A, Kjell, Douglas P, Held, C. Brad, Frederick, Michael O

“…A new synthesis for an intermediate of abemaciclib is described. Keys to this route are the use of inexpensive starting materials, biphasic amine alkylation…”
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Mitigating the Risk of Coprecipitation of Pinacol during Isolation from Telescoped Miyaura Borylation and Suzuki Couplings Utilizing Boron Pinacol Esters: Use of Modeling for Process Design by Merritt, Jeremy M, Andiappan, Marimuthu, Pietz, Mark A, Richey, Rachel N, Sullivan, Kevin A, Kjell, Douglas P

“…Process definition and optimization of a telescoped Miyaura borylation and Suzuki coupling reaction employing bis­(pinacolato)­diboron (BisPin), used in the…”
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Practical Asymmetric Synthesis of an Edivoxetine·HCl Intermediate via an Efficient Diazotization Process by Kopach, Michael E, Heath, Perry C, Scherer, Roger B, Pietz, Mark A, Astleford, Bret A, McCauley, Mary Kay, Singh, Utpal K, Wong, Sze Wing, Coppert, David M, Kerr, Mark S, Houghton, Peter G, Rhodes, Gary A, Tharp, Gregg A

“…A convergent synthesis of (S)-(4-benzylmorpholin-2-yl)­(morpholino)­methanone methanesulfonate (1), a key regulatory starting material for edivoxetine·HCl, was…”
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Practical Synthesis of Chiral 2-Morpholine: (4-Benzylmorpholin-2-(S)-yl)-(tetrahydropyran-4-yl)methanone Mesylate, a Useful Pharmaceutical Intermediate by Kopach, Michael E, Singh, Utpal K, Kobierski, Michael E, Trankle, William G, Murray, Michael M, Pietz, Mark A, Forst, Mindy B, Stephenson, Gregory A, Mancuso, Vincent, Giard, Thierry, Vanmarsenille, Michel, DeFrance, Thierry

“…A commercial synthesis was developed for the production of (4-benzylmorpholin-2-(S)-yl)-(tetrahydropyran-4-yl)methanone mesylate, 1a, a key starting material…”
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Identifying Scale Sensitivity for API Crystallizations from Desupersaturation Measurements by Singh, Utpal K, Pietz, Mark A, Kopach, Michael E

“…The present report details a methodology for discriminating between mass transfer- and surface integration-controlled crystallizations. Initial…”
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Pilot-Plant Preparation of an αvβ3 Integrin Antagonist. Part 3. Process Research and Development of a Diisopropylcarbodiimide and Catalytic 1-Hydroxybenzotriazole Peptide Coupling by Clark, Jerry D, Anderson, D. Keith, Banaszak, David V, Brown, Derek B, Czyzewski, Ann M, Edeny, Albert D, Forouzi, Puneh S, Gallagher, Donald J, Iskos, V. H, Kleine, H. Peter, Knable, Carl M, Lantz, Melissa K, Lapack, Mark A, Moore, Christine M. V, Muellner, Frank W, Murphy, James B, Orihuela, Carlos A, Pietz, Mark A, Rogers, Thomas E, Ruminski, Peter G, Santhanam, Harish K, Schilke, Tobin C, Shah, Ajit S, Sheikh, Ahmad Y, Weisenburger, Gerald A, Wise, Bruce E

“…Studies directed toward the process research, development, and scale-up preparation of the potential αvβ3 integrin antagonist 1 are described. A convergent…”
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Pilot-Plant Preparation of an α v β 3 Integrin Antagonist: Process Development of a Carbonyldiimidazole Peptide Coupling by Weisenburger, Gerald A., Anderson, D. Keith, Clark, Jerry D., Edney, Albert D., Karbin, Puneh S., Gallagher, Donald J., Knable, Carl M., Pietz, Mark A.

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Pilot-Plant Preparation of an α v β 3 Integrin Antagonist. Part 3. Process Research and Development of a Diisopropylcarbodiimide and Catalytic 1-Hydroxybenzotriazole Peptide Coupling by Clark, Jerry D., Anderson, D. Keith, Banaszak, David V., Brown, Derek B., Czyzewski, Ann M., Edeny, Albert D., Forouzi, Puneh S., Gallagher, Donald J., Iskos, V. H., Kleine, H. Peter, Knable, Carl M., Lantz, Melissa K., Lapack, Mark A., Moore, Christine M. V., Muellner, Frank W., Murphy, James B., Orihuela, Carlos A., Pietz, Mark A., Rogers, Thomas E., Ruminski, Peter G., Santhanam, Harish K., Schilke, Tobin C., Shah, Ajit S., Sheikh, Ahmad Y., Weisenburger, Gerald A., Wise, Bruce E.

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Pilot-Plant Preparation of an αvβ3 Integrin Antagonist: Process Development of a Carbonyldiimidazole Peptide Coupling by Weisenburger, Gerald A, Anderson, D. Keith, Clark, Jerry D, Edney, Albert D, Karbin, Puneh S, Gallagher, Donald J, Knable, Carl M, Pietz, Mark A

“…The process development of a peptide coupling with CDI is discussed. Various solvents, addition orders, stoichiometries, and reaction temperatures were…”
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