Search Results - "Pietrek, Lisa M."

Hierarchical Ensembles of Intrinsically Disordered Proteins at Atomic Resolution in Molecular Dynamics Simulations by Pietrek, Lisa M, Stelzl, Lukas S, Hummer, Gerhard

“…Intrinsically disordered proteins (IDPs) constitute a large fraction of the human proteome and are critical in the regulation of cellular processes. A detailed…”
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Driving forces behind phase separation of the carboxy-terminal domain of RNA polymerase II by Flores-Solis, David, Lushpinskaia, Irina P., Polyansky, Anton A., Changiarath, Arya, Boehning, Marc, Mirkovic, Milana, Walshe, James, Pietrek, Lisa M., Cramer, Patrick, Stelzl, Lukas S., Zagrovic, Bojan, Zweckstetter, Markus

“…Eukaryotic gene regulation and pre-mRNA transcription depend on the carboxy-terminal domain (CTD) of RNA polymerase (Pol) II. Due to its highly repetitive,…”
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Global Structure of the Intrinsically Disordered Protein Tau Emerges from Its Local Structure by Stelzl, Lukas S, Pietrek, Lisa M, Holla, Andrea, Oroz, Javier, Sikora, Mateusz, Köfinger, Jürgen, Schuler, Benjamin, Zweckstetter, Markus, Hummer, Gerhard

“…The paradigmatic disordered protein tau plays an important role in neuronal function and neurodegenerative diseases. To disentangle the factors controlling the…”
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Structural ensembles of disordered proteins from hierarchical chain growth and simulation by Pietrek, Lisa M., Stelzl, Lukas S., Hummer, Gerhard

“…Disordered proteins and nucleic acids play key roles in cellular function and disease. Here, we review recent advances in the computational exploration of the…”
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Hierarchical Assembly of Single-Stranded RNA by Pietrek, Lisa M., Stelzl, Lukas S., Hummer, Gerhard

“…Single-stranded RNA (ssRNA) plays a major role in the flow of genetic information–most notably, in the form of messenger RNA (mRNA)–and in the regulation of…”
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Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation by Gruijs da Silva, Lara A, Simonetti, Francesca, Hutten, Saskia, Riemenschneider, Henrick, Sternburg, Erin L, Pietrek, Lisa M, Gebel, Jakob, Dötsch, Volker, Edbauer, Dieter, Hummer, Gerhard, Stelzl, Lukas S, Dormann, Dorothee

“…Post‐translational modifications (PTMs) have emerged as key modulators of protein phase separation and have been linked to protein aggregation in…”
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From integrative atomic-resolution ensembles of disordered proteins to simulations of phase-separated condensates by Stelzl, Lukas S., Pietrek, Lisa M., Ping, Xiaofei, Holla, Andrea, Sikora, Mateusz, Koefinger, Juergen, Dormann, Dorothee, Schuler, Benjamin, Zweckstetter, Markus, Hummer, Gerhard

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Structural ensembles of disordered proteins from hierarchical chain growth and simulation by Pietrek, Lisa M, Stelzl, Lukas S, Hummer, Gerhard

“…Disordered proteins and nucleic acids play key roles in cellular function and disease. Here we review recent advances in the computational exploration of the…”
Get full text