Search Results - "Pietras, R"

CNS Adverse Effects: From Functional Observation Battery/Irwin Tests to Electrophysiology by Fonck, Carlos, Easter, Alison, Pietras, Mark R, Bialecki, Russell A

“…This chapter describes various approaches for the preclinical assessment of drug-induced central nervous system (CNS) adverse effects. Traditionally, methods…”
Get more information

Rational Combinations of Trastuzumab With Chemotherapeutic Drugs Used in the Treatment of Breast Cancer by Pegram, Mark D., Konecny, Gottfried E., O'Callaghan, Carminda, Beryt, Malgorzata, Pietras, Richard, Slamon, Dennis J.

“…Background: Trastuzumab, a humanized anti-HER2 antibody, increases the clinical benefit of first-line chemotherapy in patients with metastatic breast cancers…”
Get full text

Estrogen and growth factor receptor interactions in human breast and non-small cell lung cancer cells by Pietras, Richard J., Márquez, Diana C., Chen, Hsiao-Wang, Tsai, Eugene, Weinberg, Olga, Fishbein, Michael

“…Extranuclear estrogen receptors may mediate rapid effects of estradiol that communicate with nuclear receptors and contribute to proliferation of human cancers…”
Get full text

Remission of human breast cancer xenografts on therapy with humanized monoclonal antibody to HER-2 receptor and DNA-reactive drugs by PIETRAS, R. J, PEGRAM, M. D, FINN, R. S, MANEVAL, D. A, SLAMON, D. J

“…HER-2 oncogene encodes a transmembrane growth factor receptor that is overexpressed in 25-30% of patients with primary breast and ovarian cancer. A murine…”
Get full text

Dimensional changes and creep of silica core ceramics used in investment casting of superalloys by WERESZCZAK, A. A, BREDER, K, FERBER, M. K, KIRKLAND, T. P, PAYZANT, E. A, RAWN, C. J, KRUG, E, LAROCCO, C. L, PIETRAS, R. A, KARAKUS, M

“…Dimensional changes and creep deformation of a silica/zircon (74%/24%, respectively) and a high silica (93% silica and 3% zircon) ceramic were characterized…”
Get full text

Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells by Pietras, R J, Fendly, B M, Chazin, V R, Pegram, M D, Howell, S B, Slamon, D J

“…Approximately 30% of human breast and ovarian cancers have amplification and/or overexpression of HER-2/neu gene which encodes a cell surface growth-factor…”
Get more information

The combination of green tea and tamoxifen is effective against breast cancer by Sartippour, Maryam R., Pietras, Richard, Marquez-Garban, Diana C., Chen, Hsiao-Wang, Heber, David, Henning, Susanne M., Sartippour, Guilan, Zhang, Liping, Lu, Ming, Weinberg, Olga, Rao, Jian Yu, Brooks, Mai N.

“…Epidemiologic data have suggested that green tea may prevent breast cancer. Studies in our laboratory have provided evidence that green tea extract inhibits…”
Get full text

The effect of HER-2/neu overexpression on chemotherapeutic drug sensitivity in human breast and ovarian cancer cells by PEGRAM, M. D, FINN, R. S, ARZOO, K, BERYT, M, PIETRAS, R. J, SLAMON, D. J

“…Recent studies indicate that oncogenes may be involved in determining the sensitivity of human cancers to chemotherapeutic agents. To define the effect of…”
Get full text

Biologic effects of heregulin/neu differentiation factor on normal and malignant human breast and ovarian epithelial cells by AGUILAR, Z, AKITA, R. W, FINN, R. S, RAMOS, B. L, PEGRAM, M. D, KABBINAVAR, F. F, PIETRAS, R. J, PISACANE, P, SLIWKOWSKI, M. X, SLAMON, D. J

“…The heregulins are a family of ligands with ability to induce phosphorylation of the p185HER-2/neu receptor. Various investigators have reported a variety of…”
Get full text

Estrogen-signaling pathways in lung cancer by Márquez-Garbán, D C, Pietras, R J

Get more information

Membrane-associated binding sites for estrogen contribute to growth regulation of human breast cancer cells by MARQUEZ, Diana C, PIETRAS, Richard J

“…Membrane-associated binding sites for estrogen may mediate rapid effects of estradiol-17beta that contribute to proliferation of human breast cancers. After…”
Get full text

New approaches to reverse resistance to hormonal therapy in human breast cancer by Weinberg, Olga K., Marquez-Garban, Diana C., Pietras, Richard J.

“…Breast cancer is now the most common malignancy diagnosed in women. Growth factor and estrogen receptors elicit tight regulation of breast tumor progression…”
Get full text

Steroid hormone receptors in target cell membranes by Pietras, R J, Nemere, I, Szego, C M

“…Numerous reports of rapid steroid hormone effects in diverse cell types cannot be explained by the generally prevailing theory that centers on the activity of…”
Get full text

Monoclonal Antibody to HER-2/neu Receptor Modulates Repair of Radiation-induced DNA Damage and Enhances Radiosensitivity of Human Breast Cancer Cells Overexpressing This Oncogene by Pietras, R J, Poen, J C, Gallardo, D, Wongvipat, P N, Lee, HJ, Slamon, D J

“…The management of human breast cancer frequently includes radiation therapy as an important intervention, and improvement in the clinical efficacy of radiation…”
Get full text

Development and validation of an HPTLC-densitometric method for determination of ACE inhibitors by KOWALCZUK, D, PIETRAS, R, HOPKAŁA, H

Get full text

Preclinical pharmacology of AZD2327: a highly selective agonist of the δ-opioid receptor by Hudzik, T J, Maciag, C, Smith, M A, Caccese, R, Pietras, M R, Bui, K H, Coupal, M, Adam, L, Payza, K, Griffin, A, Smagin, G, Song, D, Swedberg, M D B, Brown, W

“…In the present article, we summarize the preclinical pharmacology of 4-{(R)-(3-aminophenyl)[4-(4-fluorobenzyl)-piperazin-1-yl]methyl}-N,N-diethylbenzamide…”
Get more information

Retention behavior of anti-arrhythmic drugs on the Chromolith Performance RP 18 column. Liquid chromatographic determination of mexiletine hydrochloride by PIETRAS, R, KOWALCZUK, D, HOPKAŁA, H

Get full text

Effects of the δ opioid agonist AZD2327 upon operant behaviors and assessment of its potential for abuse by Hudzik, T.J., Pietras, M.R., Caccese, R., Bui, K.H., Yocca, F., Paronis, C.A., M.D.B., Swedberg

“…AZD2327 is a brain-penetrant agonist at δ opioid receptors which has antidepressant and anxiolytic properties in a wide array of animal models. As part of the…”
Get full text

Cell membrane estrogen receptors resurface by Pietras, Richard J, Szego, Clara M

Get full text

Overview of the FASEB 2004 Summer Research Conference on Steroid Hormone Receptors: Integration of Plasma Membrane and Nuclear-Initiated Signaling in Hormone Action by Pietras, Richard J.

Get full text