Search Results - "Pietras, M."

Inflammation: a key regulator of hematopoietic stem cell fate in health and disease by Pietras, Eric M.

“…Hematopoietic stem cells (HSCs) are responsible for lifelong production of blood cells. At the same time, they must respond rapidly to acute needs such as…”
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Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection by Caiado, Francisco, Pietras, Eric M, Manz, Markus G

“…Inflammation is an evolutionarily selected defense response to infection or tissue damage that involves activation and consumption of immune cells in order to…”
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Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions by Pietras, Eric M., Reynaud, Damien, Kang, Yoon-A., Carlin, Daniel, Calero-Nieto, Fernando J., Leavitt, Andrew D., Stuart, Joshua M., Göttgens, Berthold, Passegué, Emmanuelle

“…Despite great advances in understanding the mechanisms underlying blood production, lineage specification at the level of multipotent progenitors (MPPs)…”
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Cell cycle regulation in hematopoietic stem cells by Pietras, Eric M, Warr, Matthew R, Passegué, Emmanuelle

“…Hematopoietic stem cells (HSCs) give rise to all lineages of blood cells. Because HSCs must persist for a lifetime, the balance between their proliferation and…”
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Pro-inflammatory cytokines: Emerging players regulating HSC function in normal and diseased hematopoiesis by Mirantes, Cristina, Passegué, Emmanuelle, Pietras, Eric M.

“…Hematopoiesis is the hierarchical process in which all lineages of blood cells are produced by self-renewing hematopoietic stem cells (HSCs) in the bone marrow…”
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Myeloproliferative Neoplasia Remodels the Endosteal Bone Marrow Niche into a Self-Reinforcing Leukemic Niche by Schepers, Koen, Pietras, Eric M., Reynaud, Damien, Flach, Johanna, Binnewies, Mikhail, Garg, Trit, Wagers, Amy J., Hsiao, Edward C., Passegué, Emmanuelle

“…Multipotent stromal cells (MSCs) and their osteoblastic lineage cell (OBC) derivatives are part of the bone marrow (BM) niche and contribute to hematopoietic…”
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Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal by Pietras, Eric M., Mirantes-Barbeito, Cristina, Fong, Sarah, Loeffler, Dirk, Kovtonyuk, Larisa V., Zhang, SiYi, Lakshminarasimhan, Ranjani, Chin, Chih Peng, Techner, José-Marc, Will, Britta, Nerlov, Claus, Steidl, Ulrich, Manz, Markus G., Schroeder, Timm, Passegué, Emmanuelle

“…Haematopoietic stem cells (HSCs) maintain lifelong blood production and increase blood cell numbers in response to chronic and acute injury. However, the…”
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Starspot Modeling and Flare Analysis on Selected Main-sequence M-type Stars by Bicz, K., Falewicz, R., Pietras, M., Siarkowski, M., Preś, P.

“…Abstract We studied the light curves of GJ 1243, YZ CMi, and V374 Peg, as observed by TESS, for the presence of stellar spots and stellar flares. One of the…”
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Clonal hematopoiesis: Mutation-specific adaptation to environmental change by Florez, Marcus A, Tran, Brandon T, Wathan, Trisha K, DeGregori, James, Pietras, Eric M, King, Katherine Y

“…Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion of genetically variant hematopoietic cells that increases exponentially…”
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Simplified murine multipotent progenitor isolation scheme: Establishing a consensus approach for multipotent progenitor identification by Challen, Grant A., Pietras, Eric M., Wallscheid, Nina Cabezas, Signer, Robert A.J.

“…•A simplified scheme for identifying murine multipotent progenitor cells is described.•This scheme was developed with assistance and feedback from the ISEH…”
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Analysis of Solar-like X-class Flare on Wolf 359 Observed Simultaneously with TESS and XMM-Newton by Pietras, M., Falewicz, R., Siarkowski, M., Kepa, A., Bicz, K., Preś, P.

“…Abstract We present an analysis of a flare on the Wolf 359 star based on simultaneous observations of Transiting Exoplanet Survey Satellite and XMM-Newton. A…”
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Statistical Analysis of Stellar Flares from the First Three Years of TESS Observations by Pietras, M., Falewicz, R., Siarkowski, M., Bicz, K., Preś, P.

“…Abstract In this paper, we study stellar light curves from the Transiting Exoplanet Survey Satellite (TESS) for the presence of stellar flares. The main aim is…”
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Analysis of the Stellar Occultations during the Unprecedented Long-duration Flare by Bicz, K., Falewicz, R., Heinzel, P., Pietras, M., Preś, P.

“…Abstract In strong stellar and solar flares, flare loops typically appear during the decay phase, providing an additional contribution to the flare emission…”
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Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors by Higa, Kelly C, Goodspeed, Andrew, Chavez, James S, De Dominici, Marco, Danis, Etienne, Zaberezhnyy, Vadym, Rabe, Jennifer L, Tenen, Daniel G, Pietras, Eric M, DeGregori, James

“…The early events that drive myeloid oncogenesis are not well understood. Most studies focus on the cell-intrinsic genetic changes and how they impact cell fate…”
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CD34 and EPCR coordinately enrich functional murine hematopoietic stem cells under normal and inflammatory conditions by Rabe, Jennifer L., Hernandez, Giovanny, Chavez, James S., Mills, Taylor S., Nerlov, Claus, Pietras, Eric M.

“…•EPCR and CD34 enrich for long-term repopulating SLAM cells in chronic IL-1 conditions.•EPCR and CD34 identify molecularly distinct SLAM fractions.•EPCR+/CD34–…”
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Myelodysplastic syndrome-associated spliceosome gene mutations enhance innate immune signaling by Pollyea, Daniel A, Harris, Chelsea, Rabe, Jennifer L, Hedin, Brenna R, De Arras, Lesly, Katz, Sigrid, Wheeler, Emily, Bejar, Rafael, Walter, Matthew J, Jordan, Craig T, Pietras, Eric M, Alper, Scott

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The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity by Cavalli, Giulio, Tengesdal, Isak W., Gresnigt, Mark, Nemkov, Travis, Arts, Rob J.W., Domínguez-Andrés, Jorge, Molteni, Raffaella, Stefanoni, Davide, Cantoni, Eleonora, Cassina, Laura, Giugliano, Silvia, Schraa, Kiki, Mills, Taylor S., Pietras, Eric M., Eisenmensser, Elan Z., Dagna, Lorenzo, Boletta, Alessandra, D’Alessandro, Angelo, Joosten, Leo A.B., Netea, Mihai G., Dinarello, Charles A.

“…Trained immunity (TI) is a de facto innate immune memory program induced in monocytes/macrophages by exposure to pathogens or vaccines, which evolved as…”
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Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis by Hernandez, Giovanny, Mills, Taylor S, Rabe, Jennifer L, Chavez, James S, Kuldanek, Susan, Kirkpatrick, Gregory, Noetzli, Leila, Jubair, Widian K, Zanche, Michelle, Myers, Jason R, Stevens, Brett M, Fleenor, Courtney J, Adane, Biniam, Dinarello, Charles A, Ashton, John, Jordan, Craig T, Di Paola, Jorge, Hagman, James R, Holers, V Michael, Kuhn, Kristine A, Pietras, Eric M

“…Rheumatoid arthritis (RA) is a debilitating autoimmune disease characterized by chronic inflammation and progressive destruction of joint tissue. It is also…”
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Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif by Saha, Supriya K, Pietras, Eric M, He, Jeannie Q, Kang, Jason R, Liu, Su-Yang, Oganesyan, Gagik, Shahangian, Arash, Zarnegar, Brian, Shiba, Travis L, Wang, Yao, Cheng, Genhong

“…Upon recognition of viral infection, RIG‐I and Helicard recruit a newly identified adapter termed Cardif, which induces type I interferon (IFN)‐mediated…”
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Maternal diet alters long-term innate immune cell memory in fetal and juvenile hematopoietic stem and progenitor cells in nonhuman primate offspring by Nash, Michael J., Dobrinskikh, Evgenia, Soderborg, Taylor K., Janssen, Rachel C., Takahashi, Diana L., Dean, Tyler A., Varlamov, Oleg, Hennebold, Jon D., Gannon, Maureen, Aagaard, Kjersti M., McCurdy, Carrie E., Kievit, Paul, Bergman, Bryan C., Jones, Kenneth L., Pietras, Eric M., Wesolowski, Stephanie R., Friedman, Jacob E.

“…Maternal overnutrition increases inflammatory and metabolic disease risk in postnatal offspring. This constitutes a major public health concern due to…”
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