Search Results - "Pietilä, Marko"

Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions by Hyvönen, Mervi T, Smirnova, Olga A, Mitkevich, Vladimir A, Tunitskaya, Vera L, Khomutov, Maxim, Karpov, Dmitry S, Korolev, Sergey P, Häkkinen, Merja R, Pietilä, Marko, Gottikh, Marina B, Vepsäläinen, Jouko, Alhonen, Leena, Makarov, Alexander A, Kochetkov, Sergey N, Wallace, Heather M, Keinänen, Tuomo A, Khomutov, Alex R

“…The polyamines, spermine (Spm) and spermidine (Spd), are important for cell growth and function. Their homeostasis is strictly controlled, and a key…”
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Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell functions by Ramot, Yuval, Tiede, Stephan, Bíró, Tamás, Abu Bakar, Mohd Hilmi, Sugawara, Koji, Philpott, Michael P, Harrison, Wesley, Pietilä, Marko, Paus, Ralf

“…Rapidly regenerating tissues need sufficient polyamine synthesis. Since the hair follicle (HF) is a highly proliferative mini-organ, polyamines may also be…”
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Enhanced Polyamine Catabolism Alters Homeostatic Control of White Adipose Tissue Mass, Energy Expenditure, and Glucose Metabolism by Pirinen, Eija, Kuulasmaa, Teemu, Pietilä, Marko, Heikkinen, Sami, Tusa, Maija, Itkonen, Paula, Boman, Susanna, Skommer, Joanna, Virkamäki, Antti, Hohtola, Esa, Kettunen, Mikko, Fatrai, Szabolcs, Kansanen, Emilia, Koota, Suvi, Niiranen, Kirsi, Parkkinen, Jyrki, Levonen, Anna-Liisa, Ylä-Herttuala, Seppo, Hiltunen, J. Kalervo, Alhonen, Leena, Smith, Ulf, Jänne, Juhani, Laakso, Markku

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Polyamines and hair: a couple in search of perfection by Ramot, Yuval, Pietilä, Marko, Giuliani, Giammaria, Rinaldi, Fabio, Alhonen, Leena, Paus, Ralf

“…Please cite this paper as: Polyamines and hair: a couple in search of perfection. Experimental Dermatology 2010; 19: 784–790. :  Polyamines (spermidine,…”
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Synthesis and Biological Characterization of Novel Charge-Deficient Spermine Analogues by Weisell, Janne, Hyvönen, Mervi T, Häkkinen, Merja R, Grigorenko, Nikolay A, Pietilä, Marko, Lampinen, Anita, Kochetkov, Sergey N, Alhonen, Leena, Vepsäläinen, Jouko, Keinänen, Tuomo A, Khomutov, Alex R

“…Biogenic polyamines, spermidine and spermine, are positively charged at physiological pH. They are present in all cells and essential for their growth and…”
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Spermidine is indispensable in differentiation of 3T3‐L1 fibroblasts to adipocytes by Vuohelainen, Susanna, Pirinen, Eija, Cerrada‐Gimenez, Marc, Keinänen, Tuomo A., Uimari, Anne, Pietilä, Marko, Khomutov, Alex R., Jänne, Juhani, Alhonen, Leena

“…Impaired adipogenesis has been shown to predispose to disturbed adipocyte function and development of metabolic abnormalities. Previous studies indicate that…”
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Systemic overexpression of antizyme 1 in mouse reduces ornithine decarboxylase activity without major changes in tissue polyamine homeostasis by Pietilä, Marko, Dhungana, Hiramani, Uimari, Anne, Sironen, Reijo, Alhonen, Leena

“…Polyamines, spermidine, spermine and their precursor putrescine, are ubiquitous cell components essential for normal cell growth. Increased polyamine levels…”
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Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A by Hyvönen, Mervi T, Koponen, Taina, Weisell, Janne, Pietilä, Marko, Khomutov, Alex R, Vepsäläinen, Jouko, Alhonen, Leena, Keinänen, Tuomo A

“…We have shown previously that the polyamine spermidine is indispensable for differentiation of 3T3-L1 preadipocytes. In the present study, we examined the…”
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Inducible expression of antizyme 1 in prostate cancer cell lines after lentivirus mediated gene transfer by Pietilä, Marko, Lampinen, Anita, Pellinen, Riikka, Alhonen, Leena

“…The prostate has the highest level of polyamines among all tissues, and it is the only tissue in which polyamines are purposely synthesized for export. It has…”
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Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults by Cerrada-Gimenez, Marc, Pietilä, Marko, Loimas, Suvikki, Pirinen, Eija, Hyvönen, Mervi T, Keinänen, Tuomo A, Jänne, Juhani, Alhonen, Leena

“…Enhanced polyamine catabolism via polyamine acetylation-oxidation elevates the oxidative stress in an organism due to increased production of reactive oxygen…”
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Activated polyamine catabolism leads to low cholesterol levels by enhancing bile acid synthesis by Pirinen, Eija, Gylling, Helena, Itkonen, Paula, Yaluri, Nagendra, Heikkinen, Sami, Pietilä, Marko, Kuulasmaa, Teemu, Tusa, Maija, Cerrada-Gimenez, Marc, Pihlajamäki, Jussi, Alhonen, Leena, Jänne, Juhani, Miettinen, Tatu A, Laakso, Markku

“…Transgenic mice with activated polyamine catabolism due to overexpression of spermidine/spermine N¹-acetyltransferase (SSAT) have significantly reduced plasma…”
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Mice with targeted disruption of spermidine/spermine N 1 -acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging by Niiranen, Kirsi, Keinänen, Tuomo A., Pirinen, Eija, Heikkinen, Sami, Tusa, Maija, Fatrai, Szabolcs, Suppola, Suvikki, Pietilä, Marko, Uimari, Anne, Laakso, Markku, Alhonen, Leena, Jänne, Juhani

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Genetic approaches to the cellular functions of polyamines in mammals by Jänne, Juhani, Alhonen, Leena, Pietilä, Marko, Keinänen, Tuomo A.

“…The polyamines putrescine, spermidine and spermine are organic cations shown to participate in a bewildering number of cellular reactions, yet their exact…”
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Genetic Manipulation of Polyamine Catabolism in Rodents by Jänne, Juhani, Alhonen, Leena, Pietilä, Marko, Keinänen, Tuomo A, Uimari, Anne, Hyvönen, Mervi T, Pirinen, Eija, Järvinen, Aki

“…Activation of polyamine catabolism through the overexpression of spermidine/spermine N¹-acetyltransferase (SSAT) in transgenic rodents does not only lead to…”
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Cutaneous application of α-methylspermidine activates the growth of resting hair follicles in mice by Fashe, Tekele M, Keinänen, Tuomo A, Grigorenko, Nikolay A, Khomutov, Alex R, Jänne, Juhani, Alhonen, Leena, Pietilä, Marko

“…Recent studies using transgenic animals have revealed a crucial role for polyamines in the development and the growth of skin and hair follicles. In mammals,…”
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Disturbed Keratinocyte Differentiation in Transgenic Mice and Organotypic Keratinocyte Cultures as a Result of Spermidine/Spermine N1-Acetyltransferase Overexpression by Pietilä, Marko, Pirinen, Eija, Keskitalo, Salla, Juutinen, Sisko, Pasonen-Seppänen, Sanna, Keinänen, Tuomo, Alhonen, Leena, Jänne, Juhani

“…Overexpression of the rate-limiting enzyme in polyamine catabolism spermidine/spermine N1-acetyltransferase (SSAT) in transgenic (Tg) mouse leads to…”
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Polyamines are required for the initiation of rat liver regeneration by ALHONEN, Leena, RÄSÄNEN, Tiina-Liisa, SINERVIRTA, Riitta, PARKKINEN, Jyrki J., KORHONEN, Veli-Pekka, PIETILÄ, Marko, JÄNNE, Juhani

“…A large number of studies applying inhibitors of polyamine biosynthesis have indicated that these compounds are required for animal cell proliferation. Here we…”
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Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs by Korhonen, V P, Niiranen, K, Halmekytö, M, Pietilä, M, Diegelman, P, Parkkinen, J J, Eloranta, T, Porter, C W, Alhonen, L, Jänne, J

“…Polyamines are known to be essential for normal cell growth and differentiation. However, despite numerous studies, specific cellular functions of polyamines…”
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Animal disease models generated by genetic engineering of polyamine metabolism by Jänne, Juhani, Alhonen, Leena, Keinänen, Tuomo A., Pietilä, Marko, Uimari, Anne, Pirinen, Eija, Hyvönen, Mervi T., Järvinen, Aki

“…The polyamines putrescine, spermidine and spermine are natural components of all living cells. Although their exact cellular functions are still largely…”
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Mice with targeted disruption of spermidine/spermine N1‐acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging by Niiranen, Kirsi, Keinänen, Tuomo A., Pirinen, Eija, Heikkinen, Sami, Tusa, Maija, Fatrai, Szabolcs, Suppola, Suvikki, Pietilä, Marko, Uimari, Anne, Laakso, Markku, Alhonen, Leena, Jänne, Juhani

“…The N1‐acetylation of spermidine or spermine by spermidine/spermine N1‐acetyltransferase (SSAT) is the ratecontrolling enzymatic step in the polyamine…”
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