Search Results - "Pieters, Tim"

Role of cell-cell adhesion complexes in embryonic stem cell biology by Pieters, Tim, van Roy, Frans

“…Pluripotent embryonic stem cells (ESCs) can self-renew or differentiate into any cell type within an organism. Here, we focus on the roles of cadherins and…”
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Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling by Pieters, Tim, van Roy, Frans, van Hengel, Jolanda

“…The functions of many organs depend on the generation of an epithelium. The transition from a set of loosely connected nonpolarized cells to organized sheets…”
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Functions of p120ctn in development and disease by Pieters, Tim, van Hengel, Jolanda, van Roy, Frans

“…p120 catenin (p120ctn), a component of the cadherin-catenin complex, was the first member to be identified in a most interesting subfamily of the Armadillo…”
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Emerging Epigenetic and Posttranslational Mechanisms Controlling Resistance to Glucocorticoids in Acute Lymphoblastic Leukemia by Borin, Cristina, Pieters, Tim, Serafin, Valentina, Ntziachristos, Panagiotis

“…Glucocorticoids are extensively used for the treatment of acute lymphoblastic leukemia as they pressure cancer cells to undergo apoptosis. Nevertheless,…”
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SOX11 regulates SWI/SNF complex components as member of the adrenergic neuroblastoma core regulatory circuitry by Decaesteker, Bieke, Louwagie, Amber, Loontiens, Siebe, De Vloed, Fanny, Bekaert, Sarah-Lee, Roels, Juliette, Vanhauwaert, Suzanne, De Brouwer, Sara, Sanders, Ellen, Berezovskaya, Alla, Denecker, Geertrui, D’haene, Eva, Van Haver, Stéphane, Van Loocke, Wouter, Van Dorpe, Jo, Creytens, David, Van Roy, Nadine, Pieters, Tim, Van Neste, Christophe, Fischer, Matthias, Van Vlierberghe, Pieter, Roberts, Stephen S., Schulte, Johannes, Ek, Sara, Versteeg, Rogier, Koster, Jan, van Nes, Johan, Zimmerman, Mark, De Preter, Katleen, Speleman, Frank

“…The pediatric extra-cranial tumor neuroblastoma displays a low mutational burden while recurrent copy number alterations are present in most high-risk cases…”
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The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling by Li, Jin, Riedt, Tamara, Goossens, Steven, Carrillo García, Carmen, Szczepanski, Sabrina, Brandes, Maria, Pieters, Tim, Dobrosch, Linne, Gütgemann, Ines, Farla, Natalie, Radaelli, Enrico, Hulpiau, Paco, Mallela, Nikhil, Fröhlich, Holger, La Starza, Roberta, Matteucci, Caterina, Chen, Tong, Brossart, Peter, Mecucci, Cristina, Huylebroeck, Danny, Haigh, Jody J., Janzen, Viktor

“…Epithelial-to-mesenchymal-transition (EMT) is critical for normal embryogenesis and effective postnatal wound healing, but is also associated with cancer…”
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Direct and indirect anti-leukemic properties of activity-on-target interferons for the treatment of T-cell acute lymphoblastic leukemia by Goossens, Steven, Cauwels, Anje, Pieters, Tim, De Smedt, Renate, T'Sas, Sara, Almeida, André, Daneels, Willem, Van Vlierberghe, Pieter, Tavernier, Jan

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Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma by De Coninck, Stien, De Smedt, Renate, Lintermans, Beatrice, Reunes, Lindy, Kosasih, Hansen J, Reekmans, Alexandra, Brown, Lauren M, Van Roy, Nadine, Palhais, Bruno, Roels, Juliette, Van der Linden, Malaika, Van Dorpe, Jo, Ntziachristos, Panagiotis, Van Delft, Frederik W, Mansour, Marc R, Pieters, Tim, Lammens, Tim, De Moerloose, Barbara, De Bock, Charles E, Goossens, Steven, Van Vlierberghe, Pieter

“…T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) are rare aggressive hematologic malignancies. Current treatment consists…”
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S239: SOX11 DRIVES B1A LINEAGE COMMITMENT AND B1A/MCL‐LIKE LYMPHOMA FORMATION IN MICE by Pieters, Tim, Pagliaro, Luca, Ntziachristos, Panagiotis, Van Vlierberghe, Pieter, Goossens, Steven

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p120 Catenin-Mediated Stabilization of E-Cadherin Is Essential for Primitive Endoderm Specification by Pieters, Tim, Goossens, Steven, Haenebalcke, Lieven, Andries, Vanessa, Stryjewska, Agata, De Rycke, Riet, Lemeire, Kelly, Hochepied, Tino, Huylebroeck, Danny, Berx, Geert, Stemmler, Marc P, Wirth, Dagmar, Haigh, Jody J, van Hengel, Jolanda, van Roy, Frans

“…E-cadherin-mediated cell-cell adhesion is critical for naive pluripotency of cultured mouse embryonic stem cells (mESCs). E-cadherin-depleted mESC fail to…”
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Efficient ROSA26-Based Conditional and/or Inducible Transgenesis Using RMCE-Compatible F1 Hybrid Mouse Embryonic Stem Cells by Haenebalcke, Lieven, Goossens, Steven, Naessens, Michael, Kruse, Natascha, Ghahremani, Morvarid Farhang, Bartunkova, Sonia, Haigh, Katharina, Pieters, Tim, Dierickx, Pieterjan, Drogat, Benjamin, Nyabi, Omar, Wirth, Dagmar, Haigh, Jody J.

“…The conditional Cre/loxP system and/or the doxycycline (Dox) inducible Tet-on/off system are widely used in mouse transgenesis but often require time…”
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Myb overexpression synergizes with the loss of Pten and is a dependency factor and therapeutic target in T‐cell lymphoblastic leukemia by Almeida, André, T'Sas, Sara, Pagliaro, Luca, Fijalkowski, Igor, Sleeckx, Wouter, Van Steenberge, Hannah, Zamponi, Raffaella, Lintermans, Béatrice, Van Loocke, Wouter, Palhais, Bruno, Reekmans, Alexandra, Bardelli, Valentina, Demoen, Lisa, Reunes, Lindy, Deforce, Dieter, Van Nieuwerburgh, Filip, Kentsis, Alex, Ntziachristos, Panagiotis, Van Roy, Nadine, De Moerloose, Barbara, Mecucci, Cristina, La Starza, Roberta, Roti, Giovanni, Goossens, Steven, Van Vlierberghe, Pieter, Pieters, Tim

“…T‐lineage acute lymphoblastic leukemia (T‐ALL) is an aggressive hematological malignancy that accounts for 10%–15% of pediatric and 25% of adult ALL cases…”
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LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19 by Helsmoortel, Hetty H, De Moerloose, Barbara, Pieters, Tim, Ghazavi, Farzaneh, Bresolin, Silvia, Cavé, Hélène, de Vries, Andrica, de Haas, Valerie, Flotho, Christian, Labarque, Veerle, Niemeyer, Charlotte, De Paepe, Pascale, Van Roy, Nadine, Stary, Jan, van den Heuvel-Eibrink, Marry M, Benoit, Yves, Schulte, Johannes, Goossens, Steven, Berx, Geert, Haigh, Jody J, Speleman, Frank, Van Vlierberghe, Pieter, Lammens, Tim

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Jmjd3 Drives Immature T-Cell Lymphoblastic Leukemia by Borin, Cristina, Pieters, Tim, Van Vlierberghe, Pieter, Ntziachristos, Panagiotis

“…Introduction: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that accounts for 15% of pediatric and 25% of adult ALL…”
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A Dual Role of SOX11 Expression in the Formation of T-Cell Acute Lymphoblastic Leukemia in Mouse Models by De Almeida, André, T'Sas, Sara, Van Ammel, Els, Van Vlierberghe, Pieter, Pieters, Tim, Goossens, Steven

“…Introduction: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that accounts for 10%-15% of pediatric and 25% of adult ALL…”
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3187 – IKAROS LOSS ENHANCES PRE-LEUKEMIC THYMOCYTE SELF-RENEWAL AND DRIVES T-ALL IN MICE by Van Trimpont, Maaike, T'Sas, Sara, Lammens, Tim, Van Vlierberghe, Pieter, Pieters, Tim, Goossens, Steven

“…T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy characterized by the clonal expansion of immature T-cell progenitors. The…”
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SOX11 Functions As an Oncogene in Lmo2-Driven T-Cell Lymphoblastic Leukemia (T-ALL) by De Almeida, André, Pieters, Tim, T'Sas, Sara, Goossens, Steven, Van Vlierberghe, Pieter

“…Background: T-lineage acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy that accounts for 10%-15% of pediatric and 25% of adult ALL…”
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Abstract A26: SOX11 drives B1a lineage commitment and B1a/MCL-like lymphoma formation in mice by Pieters, Tim, Goossens, Steven, Van Vlierberghe, Pieter

“…Abstract Mantle cell lymphoma (MCL) is a highly aggressive B cell lymphoma that accounts for 6% of all non-Hodgkin lymphomas and is characterized by abnormal…”
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Mutations in the histone methyltransferase Ezh2 drive context-dependent leukemia in Xenopus tropicalis by Tulkens, Dieter, Boelens, Marthe, Naert, Thomas, Carron, Marjolein, Demuynck, Suzan, Dewaele, Sylviane, Van Isterdael, Gert, Creytens, David, Pieters, Tim, Goossens, Steven, Van Vlierberghe, Pieter, Vleminckx, Kris

“…CRISPR-mediated simultaneous targeting of candidate tumor suppressor genes in Xenopus tropicalis allows fast functional assessment of co-driver genes for…”
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The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia by Van der Meulen, Joni, Sanghvi, Viraj, Mavrakis, Konstantinos, Durinck, Kaat, Fang, Fang, Matthijssens, Filip, Rondou, Pieter, Rosen, Monica, Pieters, Tim, Vandenberghe, Peter, Delabesse, Eric, Lammens, Tim, De Moerloose, Barbara, Menten, Björn, Van Roy, Nadine, Verhasselt, Bruno, Poppe, Bruce, Benoit, Yves, Taghon, Tom, Melnick, Ari M., Speleman, Frank, Wendel, Hans-Guido, Van Vlierberghe, Pieter

“…T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive form of leukemia that is mainly diagnosed in children and shows a skewed gender distribution…”
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