Search Results - "Pieters, R J"

Uptake and Transport of Superparamagnetic Iron Oxide Nanoparticles through Human Brain Capillary Endothelial Cells by Thomsen, L. B, Linemann, T, Pondman, K. M, Lichota, J, Kim, K. S, Pieters, R. J, Visser, G. M, Moos, T

“…The blood–brain barrier (BBB) formed by brain capillary endothelial cells (BCECs) constitutes a firm physical, chemical, and immunological barrier, making the…”
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Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk by Mukherjee, R, van de Kaa, M, Garssen, J, Pieters, R J, Kraneveld, A D, Willemsen, L E M

“…Lactulose, a non-digestible oligosaccharide and functional food, promotes Bifidobacteria growth. Here we show that lactulose, beyond its prebiotic action, may…”
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Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy by Broekgaarden, M, van Vught, R, Oliveira, S, Roovers, R C, van Bergen en Henegouwen, P M P, Pieters, R J, Van Gulik, T M, Breukink, E, Heger, M

“…Photodynamic therapy for therapy-resistant cancers will greatly benefit from targeted delivery of tumor photosensitizing agents. In this study, a strategy for…”
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Topically used corticosteroids: What is the big picture of drug product degradation? by van Heugten, A.J.P., de Boer, W., de Vries, W.S., Pieters, R.J., Vromans, H.

“…Corticosteroids are widely used in topical formulations such as creams (aqueous) and ointments (non-aqueous). The generally used corticosteroids show large…”
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Wedgelike Glycodendrimers as Inhibitors of Binding of Mammalian Galectins to Glycoproteins, Lactose Maxiclusters, and Cell Surface Glycoconjugates by André, Sabine, Pieters, Roland J., Vrasidas, Ioannis, Kaltner, Herbert, Kuwabara, Ichiro, Liu, Fu‐Tong, Liskamp, Rob M. J., Gabius, Hans‐Joachim

“…Galectins are mammalian carbohydrate‐binding proteins that are involved in cell–cell and cell–matrix adhesion, cell migration, and growth regulation with…”
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Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells by KOPITZ, Jürgen, ANDRE, Sabine, HECK, Albert J. R, GABIUS, Hans-Joachim, VON REITZENSTEIN, Carolina, VERSLUIS, Kees, KALTNER, Herbert, PIETERS, Roland J, WASANO, Kojiro, KUWABARA, Ichiro, LIU, Fu-Tong, CANTZ, Michael

“…The extracellular functions of galectin-7 (p53-induced gene 1) are largely unknown. On the surface of neuroblastoma cells (SK-N-MC), the increased GM1 density,…”
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Inhibition of Streptococcus suis Adhesion by Dendritic Galabiose Compounds at Low Nanomolar Concentration by JOOSTEN, John A. F., LOIMARANTA, Vuokko, APPELDOORN, Chantal C. M., HAATAJA, Sauli, EL MAATE, Fatna Ait, LISKAMP, Rob M. J., FINNE, Jukka, PIETERS, Roland J.

“…A series of mono-, di-, and tetravalent galabiose (Galalpha1-4Gal) compounds were synthesized in good yields by coupling of a general carboxylic acid-bearing…”
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Design and synthesis of reagents for phage display screening of dehalogenases by Pieters, Roland J, Fennema, Marko, Kellogg, Richard M, Janssen, Dick B

“…Bifunctional molecules containing both a biotin and a substrate unit have been designed and synthesized for phage display screening of mutant libraries of…”
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Adhesion Inhibition of F1C-Fimbriated Escherichia coli and Pseudomonas aeruginosa PAK and PAO by Multivalent Carbohydrate Ligands by Autar, Reshma, Khan, A. Salam, Schad, Matthias, Hacker, Jörg, Liskamp, Rob M.J, Pieters, Roland J

“…In order to evaluate their inhibition of bacterial adhesion, the carbohydrate sequences GalNAcβ1→4Gal and GalNAcβ1→4Galβ1→4Glc were synthesized. The…”
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Synthesis and binding studies of carboxylate binding pocket analogs of vancomycin by Pieters, Roland J

“…Synthetic receptors based on the carboxylate binding pocket of vancomycin were synthesized. Using a UV binding assay, affinities of various cell wall related…”
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Mutation of Tyrosine Residues Involved in the Alkylation Half Reaction of Epoxide Hydrolase from Agrobacterium radiobacter AD1 Results in Improved Enantioselectivity by Rink, Rick, Lutje Spelberg, Jeffrey H, Pieters, Roland J, Kingma, Jaap, Nardini, Marco, Kellogg, Richard M, Dijkstra, Bauke W, Janssen, Dick B

“…Enantiomerically pure epoxides (oxiranes) are uniquely suited building blocks for synthetic purposes. Such epoxides are often prepared by means of remarkably…”
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Identification of laminin-binding motifs of Yersinia pestis plasminogen activator by phage display by Benedek, Orsolya, Salam Khan, A., Schneider, György, Nagy, Gábor, Autar, Reshma, Pieters, Roland J., Emődy, Levente

“…Yersinia pestis plasminogen activator (Pla), a surface virulence factor contributes to the highly invasive nature of the pathogen by binding various tissue…”
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High enantioselectivity in the intramolecular cyclopropanation of allyl diazoacetates using a novel rhodium(II) catalyst by Doyle, Michael P, Pieters, Roland J, Martin, Stephen F, Austin, Richard E, Oalmann, Christopher J, Mueller, Paul

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Synthesis of nitrogen-containing polycycles via rhodium(II)-induced cyclization-cycloaddition and insertion reactions of N-(diazoacetoacetyl)amides. Conformational control of reaction selectivity by Doyle, Michael P, Pieters, Roland J, Taunton, Jack, Pho, Hoan Q, Padwa, Albert, Hertzog, Donald L, Precedo, Laura

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Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry by Rijkers, Dirk T S, van Esse, G Wilma, Merkx, Remco, Brouwer, Arwin J, Jacobs, Hans J F, Pieters, Roland J, Liskamp, Rob M J

“…Multivalent dendrimeric peptides were synthesized via a microwave-assisted Huisgen 1,3-dipolar cycloaddition between azido peptides and dendrimeric alkynes in…”
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High-Yielding Microwave-Assisted Synthesis of Triazole-Linked Glycodendrimers by Copper-Catalyzed [3+2] Cycloaddition by Joosten, John A. F., Tholen, Niels T. H., Ait El Maate, Fatna, Brouwer, Arwin J., van Esse, G. Wilma, Rijkers, Dirk T. S., Liskamp, Rob M. J., Pieters, Roland J.

“…A facile and high‐yielding synthesis of multivalent 1,4‐disubstituted 1,2,3‐triazole‐linked glycodendrimers is described. Azido carbohydrates are linked by a…”
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Synthesis and cholera toxin binding properties of multivalent GM1 mimics by Arosio, Daniela, Vrasidas, Ioannis, Valentini, Paola, Liskamp, Rob M J, Pieters, Roland J, Bernardi, Anna

“…Dendrimers based on the 3,5-di-(2-aminoethoxy)-benzoic acid branching unit were used to attach multiple copies of a GM1 mimic for inhibition of cholera toxin…”
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Rigidified multivalent lactose molecules and their interactions with mammalian galectins: a route to selective inhibitors by Vrasidas, Ioannis, André, Sabine, Valentini, Paola, Böck, Corina, Lensch, Martin, Kaltner, Herbert, Liskamp, Rob M, Gabius, Hans-J, Pieters, Roland J

“…New and rigid multivalent lactose molecules were prepared. The structures contain lactose-2-aminothiazoline units at the periphery that were formed from a…”
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New Chemical Probe for Proteomics of Carbohydrate-Binding Proteins by Ballell, Lluis, Alink, Kirstin J, Slijper, Monique, Versluis, Cees, Liskamp, Rob M.J, Pieters, Roland J

“…Selective capture of galectins, while leaving other proteins untouched, was achieved by activating photoaffinity labels that were precisely positioned on…”
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Novel multivalent mannose compounds and their inhibition of the adhesion of type 1 fimbriated uropathogenic E. coli by Appeldoorn, Chantal C.M., Joosten, John A.F., Ait el Maate, Fatna, Dobrindt, Ulrich, Hacker, Jörg, Liskamp, Rob M.J., Khan, A. Salam, Pieters, Roland J.

“…[Display omitted] A series of multivalent mannose containing compounds were prepared varying in size from small divalent, to 16-valent glycodenrimers and…”
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