Search Results - "Pieterman, E."

Higher Dosing of Rifamycins Does Not Increase Activity against Mycobacterium tuberculosis in the Hollow-Fiber Infection Model by Pieterman, E D, van den Berg, S, van der Meijden, A, Svensson, E M, Bax, H I, de Steenwinkel, J E M

“…Improvements in the translational value of preclinical models can allow more-successful and more-focused research on shortening the duration of tuberculosis…”
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Advanced Quantification Methods To Improve the 18b Dormancy Model for Assessing the Activity of Tuberculosis Drugs In Vitro by Pieterman, E D, Sarink, M J, Sala, C, Cole, S T, de Steenwinkel, J E M, Bax, H I

“…One of the reasons for the lengthy tuberculosis (TB) treatment is the difficulty to treat the nonmultiplying mycobacterial subpopulation. In order to assess…”
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Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE3Leiden.CETP mice--a translational model for atherosclerosis by Gierman, L M, Kühnast, S, Koudijs, A, Pieterman, E J, Kloppenburg, M, van Osch, G J V M, Stojanovic-Susulic, V, Huizinga, T W J, Princen, H M G, Zuurmond, A-M

“…Hypercholesterolaemia, a risk factor for atherosclerosis (ATH), has been suggested to have a role in the development of osteoarthritis (OA). To test this…”
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A multicentre verification study of the QuantiFERON®-TB Gold Plus assay by Pieterman, E.D., Liqui Lung, F.G., Verbon, A., Bax, H.I., Ang, C.W., Berkhout, J., Blaauw, G., Brandenburg, A., van Burgel, N.D., Claessen, A., van Dijk, K., Heron, M., Hooghiemstra, M., Leussenkamp-Hummelink, R., van Lochem, E., van Loo, I.H.M., Mulder, B., Ott, A., Pontesilli, O., Reuwer, A., Rombouts, P., Saegeman, V., Scholing, M., Vainio, S., de Steenwinkel, J.E.M.

“…The aim of this verification study was to compare the QuantiFERON®-TB Gold Plus (QFT-Plus) to the QuantiFERON®-TB Gold In Tube (QFT-GIT). The new QFT-Plus test…”
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IL-1β inhibition combined with cholesterol-lowering therapies decreases synovial lining thickness and spontaneous cartilage degeneration in a humanized dyslipidemia mouse model by van Gemert, Y., Kruisbergen, N.N.L., Blom, A.B., van den Bosch, M.H.J., van der Kraan, P.M., Pieterman, E.J., Princen, H.M.G., van Lent, P.L.E.M.

“…Both systemic inflammation and dyslipidemia contribute to osteoarthritis (OA) development and have been suggested as a possible link between metabolic disease…”
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Novel high-intensive cholesterol-lowering therapies do not ameliorate knee OA development in humanized dyslipidemic mice by van Gemert, Y., Kozijn, A.E., Pouwer, M.G., Kruisbergen, N.N.L., van den Bosch, M.H.J., Blom, A.B., Pieterman, E.J., Weinans, H., Stoop, R., Princen, H.M.G., van Lent, P.L.E.M.

“…High systemic cholesterol levels have been associated with osteoarthritis (OA) development. Therefore, cholesterol lowering by statins has been suggested as a…”
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Intensive cholesterol-lowering treatment reduces synovial inflammation during early collagenase-induced osteoarthritis, but not pathology at end-stage disease in female dyslipidemic E3L.CETP mice by van Gemert, Y., Blom, A.B., Di Ceglie, I., Walgreen, B., Helsen, M., Sloetjes, A., Vogl, T., Roth, J., Kruisbergen, N.N.L., Pieterman, E.J., Princen, H.M.G., van der Kraan, P.M., van Lent, P.L.E.M., van den Bosch, M.H.J.

“…The association between metabolic syndrome (MetS) and osteoarthritis (OA) development has become increasingly recognized. In this context, the exact role of…”
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Anacetrapib reduces progression of atherosclerosis, mainly by reducing non-HDL-cholesterol, improves lesion stability and adds to the beneficial effects of atorvastatin by Kühnast, Susan, van der Tuin, Sam J L, van der Hoorn, José W A, van Klinken, Jan B, Simic, Branko, Pieterman, Elsbet, Havekes, Louis M, Landmesser, Ulf, Lüscher, Thomas F, Willems van Dijk, Ko, Rensen, Patrick C N, Jukema, J Wouter, Princen, Hans M G

“…The residual risk that remains after statin treatment supports the addition of other LDL-C-lowering agents and has stimulated the search for secondary…”
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APOE3Leiden.CETP transgenic mice as model for pharmaceutical treatment of the metabolic syndrome by van den Hoek, A. M., van der Hoorn, J. W. A., Maas, A. C., van den Hoogen, R. M., van Nieuwkoop, A., Droog, S., Offerman, E. H., Pieterman, E. J., Havekes, L. M., Princen, H. M. G.

“…Aims This study aimed to investigate systematically (i) the appropriate dietary conditions to induce the features of the MetS in APOE*3Leiden.humanCholesteryl…”
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Variable cartilage degradation in mice with diet-induced metabolic dysfunction: food for thought by Kozijn, A.E., Gierman, L.M., van der Ham, F., Mulder, P., Morrison, M.C., Kühnast, S., van der Heijden, R.A., Stavro, P.M., van Koppen, A., Pieterman, E.J., van den Hoek, A.M., Kleemann, R., Princen, H.M.G., Mastbergen, S.C., Lafeber, F.P.J.G., Zuurmond, A.-M., Bobeldijk, I., Weinans, H., Stoop, R.

“…Human cohort studies have demonstrated a role for systemic metabolic dysfunction in osteoarthritis (OA) pathogenesis in obese patients. To explore the…”
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The APOE3Leiden.GK+/- mouse as novel translational model for dyslipidemia, type 2 diabetes and macrovascular complications by Pouwer, M, Heinonen, S, Behrendt, M, Andréasson, A.C, Pieterman, E, van den Hoek, A, Jukema, W, Leighton, B, Jönsson-Rylander, A.C, Princen, H

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Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of TIMP-1 and TIMP-3 by VAN DER LAAN, W. H, QUAX, P. H. A, HUIZINGA, T. W. J, PAP, T, SEEMAYER, C. A, HUISMAN, L. G. M, PIETERMAN, E. J, GRIMBERGEN, J. M, VERHEIJEN, J. H, BREEDVELD, F. C, GAY, R. E, GAY, S

“…Matrix metalloproteinases (MMPs) are believed to be pivotal enzymes in the invasion of articular cartilage by synovial tissue in rheumatoid arthritis (RA)…”
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Invasive properties of fibroblast-like synoviocytes: correlation with growth characteristics and expression of MMP-1, MMP-3, and MMP-10 by Tolboom, T C A, Pieterman, E, van der Laan, W H, Toes, R E M, Huidekoper, A L, Nelissen, R G H H, Breedveld, F C, Huizinga, T W J

“…Background: Matrix metalloproteinases (MMPs) have a pivotal role in the destruction of cartilage in rheumatoid arthritis (RA), which is mediated by the…”
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Discovery of distinctive gene expression profiles in rheumatoid synovium using cDNA microarray technology: evidence for the existence of multiple pathways of tissue destruction and repair by VAN DER POUW KRAAN, T. C. T. M, VAN GAALEN, F. A, HUIZINGA, T. W. J, PIETERMAN, E, BREEDVELD, F. C, VERWEIJ, C. L

“…Rheumatoid arthritis (RA) is a heterogeneous disease. We used cDNA microarray technology to subclassify RA patients and disclose disease pathways in rheumatoid…”
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Quantification of left ventricular regional myocardial function using MRI feature tracking in healthy children - a dual-center study by Eichhorn, Joachim G, Buss, Sebastian, Foell, Angela, Helling, Astrid, Robbers-Visser, Daniel, Pieterman, E, Bossers, Sjoerd, Lossnitzer, Dirk, Gorenflo, Matthias, Helbing, Willem A

“…Doc number: O42…”
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Six microsatellite markers on the short arm of chromosome 6 in relation to HLA-DR3 and TNF-308A in systemic lupus erythematosus by van der Linden, M W, van der Slik, A R, Zanelli, E, Giphart, M J, Pieterman, E, Schreuder, G M, Westendorp, R G, Huizinga, T W

“…Differences in allelic distribution at loci surrounding the human HLA-DRB1 and tumor necrosis factor (TNF) genes have been observed in association with…”
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The Structurally Engineered Fatty Acid Icosabutate Improves Lipid Metabolism And Reduces Severity Of Atherogenesis In Mice by Stokman, G., van den Hoek, A., Pieterman, E., Verschuren, L., Fraser, D., Princen, H.

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Semaglutide has beneficial effects on non-alcoholic steatohepatitis in Ldlr-/-.Leiden mice by Inia, J., Stokman, G., Pieterman, E., Morrison, M., Worms, N., Verschuren, L., Caspers, M., Menke, A., Petitjean, L., Petitjean, M., Jukema, J.W., Chen, L., Princen, H., Van Den Hoek, A.

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The tyrosine kinase inhibitor nilotinib targets the discoidin domain receptor DDR2 in calcific aortic valve stenosis by Carracedo, Miguel, Pawelzik, Sven‐Christian, Artiach, Gonzalo, Pouwer, Marianne G., Plunde, Oscar, Saliba‐Gustafsson, Peter, Ehrenborg, Ewa, Eriksson, Per, Pieterman, Elsbet, Stenke, Leif, Princen, Hans M. G., Franco‐Cereceda, Anders, Bäck, Magnus

“…Background and Purpose Tyrosine kinase inhibitors (TKI) used to treat chronic myeloid leukaemia (CML) have been associated with cardiovascular side effects,…”
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Oral Atorvastatin Induces Plaque Regression By Inhibiting Macrophage Proliferation by Härdtner, C., Kornemann, J., Krebs, K., Sharipova, D., Dufner, B., Hoppe, N., Pieterman, E., H. Princen, M.G., Ho-Tin-Noé, B., Bode, C., Zirlik, A., Hilgendorf, I., Ehlert, C.

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