Search Results - "Piers, Thomas"

A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC‐derived microglia by Piers, Thomas M., Cosker, Katharina, Mallach, Anna, Johnson, Gabriel Thomas, Guerreiro, Rita, Hardy, John, Pocock, Jennifer M.

“…Loss‐of‐function genetic variants of triggering receptor expressed on myeloid cells 2 (TREM2) are linked with an enhanced risk of developing dementias…”
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Modelling microglial function with induced pluripotent stem cells: an update by Pocock, Jennifer M., Piers, Thomas M.

“…It is becoming increasingly apparent that microglia, the immune cells of the CNS, and their peripheral counterparts, macrophages, have a major role in normal…”
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Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions by Liu, Wenfei, Taso, Orjona, Wang, Rui, Bayram, Sevinc, Graham, Andrew C, Garcia-Reitboeck, Pablo, Mallach, Anna, Andrews, William D, Piers, Thomas M, Botia, Juan A, Pocock, Jennifer M, Cummings, Damian M, Hardy, John, Edwards, Frances A, Salih, Dervis A

“…Abstract Genome-wide association studies have reported that, amongst other microglial genes, variants in TREM2 can profoundly increase the incidence of…”
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Human myeloid progenitor glucocorticoid receptor activation causes genomic instability, type 1 IFN‐ response pathway activation and senescence in differentiated microglia; an early life stress model by Wei, Jingzhang, Arber, Charles, Wray, Selina, Hardy, John, Piers, Thomas M., Pocock, Jennifer M.

“…One form of early life stress, prenatal exposure to glucocorticoids (GCs), confers a higher risk of psychiatric and neurodevelopmental disorders in later life…”
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A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene by Magusali, Naciye, Graham, Andrew C, Piers, Thomas M, Panichnantakul, Pantila, Yaman, Umran, Shoai, Maryam, Reynolds, Regina H, Botia, Juan A, Brookes, Keeley J, Guetta-Baranes, Tamar, Bellou, Eftychia, Bayram, Sevinc, Sokolova, Dimitra, Ryten, Mina, Sala Frigerio, Carlo, Escott-Price, Valentina, Morgan, Kevin, Pocock, Jennifer M, Hardy, John, Salih, Dervis A

“…Recently, we reported oligoadenylate synthetase 1 (OAS1) contributed to the risk of Alzheimer's disease, by its enrichment in transcriptional networks…”
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Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis by Garcia-Reitboeck, Pablo, Phillips, Alexandra, Piers, Thomas M., Villegas-Llerena, Claudio, Butler, Matt, Mallach, Anna, Rodrigues, Celia, Arber, Charles E., Heslegrave, Amanda, Zetterberg, Henrik, Neumann, Harald, Neame, Stephen, Houlden, Henry, Hardy, John, Pocock, Jennifer M.

“…Dysfunction of microglia, the brain’s immune cells, is linked to neurodegeneration. Homozygous missense mutations in TREM2 cause Nasu-Hakola disease (NHD), an…”
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The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans by Xiang, Xianyuan, Piers, Thomas M, Wefers, Benedikt, Zhu, Kaichuan, Mallach, Anna, Brunner, Bettina, Kleinberger, Gernot, Song, Wilbur, Colonna, Marco, Herms, Jochen, Wurst, Wolfgang, Pocock, Jennifer M, Haass, Christian

“…The R47H variant of the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) significantly increases the risk for late onset Alzheimer's disease. Mouse…”
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Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome by Cosker, Katharina, Mallach, Anna, Limaye, Janhavi, Piers, Thomas M., Staddon, James, Neame, Stephen J., Hardy, John, Pocock, Jennifer M.

“…The R47H variant of the microglial membrane receptor TREM2 is linked to increased risk of late onset Alzheimer’s disease. Human induced pluripotent stem cell…”
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Tau phosphorylation at serine 396 residue is required for hippocampal LTD by Regan, Philip, Piers, Thomas, Yi, Jee-Hyun, Kim, Dong-Hyun, Huh, Seonghoo, Park, Se Jin, Ryu, Jong Hoon, Whitcomb, Daniel J, Cho, Kwangwook

“…Tau is required for the induction of long-term depression (LTD) of synaptic transmission in the hippocampus. Here we probe the role of tau in LTD, finding that…”
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Microtubule-associated protein tau is essential for long-term depression in the hippocampus by Kimura, Tetsuya, Whitcomb, Daniel J., Jo, Jihoon, Regan, Philip, Piers, Thomas, Heo, Seonghoo, Brown, Christopher, Hashikawa, Tsutomu, Murayama, Miyuki, Seok, Heon, Sotiropoulos, Ioannis, Kim, Eunjoon, Collingridge, Graham L., Takashima, Akihiko, Cho, Kwangwook

“…The microtubule-associated protein tau is a principal component of neurofibrillary tangles, and has been identified as a key molecule in Alzheimer's disease…”
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Intracranial pressure monitoring in severe traumatic brain injury: Quo Vadis? by Rosenfeld, Jeffrey V., Thomas, Piers A. W., Hunn, Martin K.

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Alzheimer's disease‐associated R47H TREM2 increases, but wild‐type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss by Popescu, Alma S., Butler, Claire A., Allendorf, David H., Piers, Thomas M., Mallach, Anna, Roewe, Julian, Reinhardt, Peter, Cinti, Alessandro, Redaelli, Loredana, Boudesco, Christophe, Pradier, Laurent, Pocock, Jennifer M., Thornton, Peter, Brown, Guy C.

“…Triggering receptor on myeloid cells 2 (TREM2) is an innate immune receptor, upregulated on the surface of microglia associated with amyloid plaques in…”
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Early Postoperative Morbidity After Chronic Subdural Hematoma: Predictive Usefulness of the Physiological and Operative Severity Score for Enumeration of Mortality and Morbidity, American College of Surgeons National Surgical Quality Improvement Program, and American Society of Anesthesiologists Grade in a Prospective Cohort by Thomas, Piers A.W., Mitchell, Paul S., Marshman, Laurence A.G.

“…Although chronic subdural hematoma (CSDH) is generally benign, long-term survival (LTS) after CSDH is poor in a significant subgroup. This dichotomy has been…”
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Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells by Nazish, Iqra, Arber, Charles, Piers, Thomas M., Warner, Thomas T., Hardy, John A., Lewis, Patrick A., Pocock, Jennifer M., Bandopadhyay, Rina

“…LRRK2 protein is expressed prominently in immune cells, cell types whose contribution to LRRK2-associated genetic Parkinson's disease (PD) is increasingly…”
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Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia by Arber, Charles, Casey, Jackie M., Crawford, Samuel, Rambarack, Naiomi, Yaman, Umran, Wiethoff, Sarah, Augustin, Emma, Piers, Thomas M., Price, Matthew, Rostagno, Agueda, Ghiso, Jorge, Lewis, Patrick A., Revesz, Tamas, Hardy, John, Pocock, Jennifer M., Houlden, Henry, Schott, Jonathan M., Salih, Dervis A., Lashley, Tammaryn, Wray, Selina

“…Mutations in ITM2B cause familial British, Danish, Chinese, and Korean dementias. In familial British dementia (FBD), a mutation in the stop codon of the ITM2B…”
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Mathematical formulae to estimate chronic subdural haematoma volume. Flawed assumption regarding ellipsoid morphology by Manickam, Appukutty, Marshman, Laurence A.G, Johnston, Ross, Thomas, Piers A.W

“…Highlights • The XYZ /2 formula has been recommended for CSDH volumetric estimation. • XYZ /2, π /6· XYZ and 2/3 S · h were compared to computer-assisted 3D…”
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Simultaneous multisystem surgery: an important capability for the civilian trauma hospital by Moore, Justin M, Thomas, Piers A.W, Gruen, Russell L, Chan, Patrick, Rosenfled, Jeffrey V

“…Highlights • We present two cases of multi-system trauma in which simultaneous operative management was undertaken in a time critical manner. • Reviews the…”
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Growth and Resorption of Chronic Subdural Hematomas: Gardner, Weir, and the Osmotic Hypothesis Revisited by Thomas, Piers A.W., Marshman, Laurence A.G., Rudd, Donna, Moffat, Claire, Mitchell, Paul S.

“…To explain why some chronic subdural hematomas (CSDHs) grow and/or resorb, a physically decreasing outer membrane (OM) surface area (SA) to CSDH volume (V)…”
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S-100β in chronic subdural haematoma: Prospective cohort study by Thomas, Piers A.W., Moffatt, Claire E., Rudd, Donna, Marshman, Laurence A.G.

“…•S-100β is used to prognosticate and manage acute neurotrauma.•S-100β was elevated in serum but was significantly higher in CSDHf.•Levels approached those…”
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Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus by Whitcomb, Daniel J., Hogg, Ellen L., Regan, Philip, Piers, Thomas, Narayan, Priyanka, Whitehead, Garry, Winters, Bryony L., Kim, Dong-Hyun, Kim, Eunjoon, St George-Hyslop, Peter, Klenerman, David, Collingridge, Graham L., Jo, Jihoon, Cho, Kwangwook

“…The acute neurotoxicity of oligomeric forms of amyloid-β 1-42 (Aβ) is implicated in the pathogenesis of Alzheimer’s disease (AD). However, how these oligomers…”
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