Search Results - "Pierreux, C. E."

Dietary supplementation of cystinotic mice by lysine inhibits the megalin pathway and decreases kidney cystine content by Rega, L. R., Janssens, V., Graversen, J. H., Moestrup, S. K., Cairoli, S., Goffredo, B. M., Nevo, N., Courtoy, G. E., Jouret, F., Antignac, C., Emma, F., Pierreux, C. E., Courtoy, P. J.

“…Megalin/LRP2 is a major receptor supporting apical endocytosis in kidney proximal tubular cells. We have previously reported that kidney-specific perinatal…”
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Hematopoietic Stem Cells Transplantation Can Normalize Thyroid Function in a Cystinosis Mouse Model by Gaide Chevronnay, H. P, Janssens, V, Van Der Smissen, P, Rocca, C. J, Liao, X. H, Refetoff, S, Pierreux, C. E, Cherqui, S, Courtoy, P. J

“…Hypothyroidism is the most frequent and earliest endocrine complication in cystinosis, a multisystemic lysosomal storage disease caused by defective…”
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A Mouse Model Suggests Two Mechanisms for Thyroid Alterations in Infantile Cystinosis: Decreased Thyroglobulin Synthesis Due to Endoplasmic Reticulum Stress/Unfolded Protein Response and Impaired Lysosomal Processing by Gaide Chevronnay, H. P, Janssens, V, Van Der Smissen, P, Liao, X. H, Abid, Y, Nevo, N, Antignac, C, Refetoff, S, Cherqui, S, Pierreux, C. E, Courtoy, P. J

“…Thyroid hormones are released from thyroglobulin (Tg) in lysosomes, which are impaired in infantile/nephropathic cystinosis. Cystinosis is a lysosomal cystine…”
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Transforming Growth Factor β-Independent Shuttling of Smad4 between the Cytoplasm and Nucleus by Pierreux, Christophe E., Nicolás, Francisco J., Hill, Caroline S.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability by Maurice, D, Pierreux, C E, Howell, M, Wilentz, R E, Owen, M J, Hill, C S

“…At early stages of tumorigenesis, the transforming growth factor-beta (TGF-beta) signaling pathway is thought to have tumor suppressor activity as a result of…”
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Liver glucokinase gene expression is controlled by the onecut transcription factor hepatocyte nuclear factor-6 by Lannoy, V J, Decaux, J F, Pierreux, C E, Lemaigre, F P, Rousseau, G G

“…Glucokinase plays a key role in glucose homeostasis and the expression of its gene is differentially regulated in pancreatic beta cells and in the liver…”
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Transcriptional stimulation by hepatocyte nuclear factor-6. Target-specific recruitment of either CREB-binding protein (CBP) or p300/CBP-associated factor (p/CAF) by Lannoy, V J, Rodolosse, A, Pierreux, C E, Rousseau, G G, Lemaigre, F P

“…Transcription factors of the ONECUT class, whose prototype is HNF-6, contain a single cut domain and a divergent homeodomain characterized by a phenylalanine…”
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Inhibition by insulin of glucocorticoid-induced gene transcription: involvement of the ligand-binding domain of the glucocorticoid receptor and independence from the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways by Pierreux, C E, Ursø, B, De Meyts, P, Rousseau, G G, Lemaigre, F P

“…Insulin can inhibit the stimulatory effect of glucocorticoid hormones on the transcription of genes coding for enzymes involved in glucose metabolism. We…”
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Antiglucocorticoid Activity of Hepatocyte Nuclear Factor-6 by Pierreux, Christophe E., Stafford, John, Demonte, Dominique, Scott, Donald K., Vandenhaute, Jean, O'Brien, Richard M., Granner, Daryl K., Rousseau, Guy G., Lemaigre, Frederic P.

“…Glucocorticoids exert their effects on gene transcription through ubiquitous receptors that bind to regulatory sequences present in many genes. These…”
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Insulin inhibition of glucocorticoid-stimulated gene transcription: requirement for an insulin response element? by Pierreux, Christophe E., Rousseau, Guy G., Lemaigre, Frédéric P.

“…The glucocorticoid hormone receptor binds to regulatory elements of target genes and activates transcription through interactions with coactivators. For a…”
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In vivo protein-DNA interactions on a glucocorticoid response unit of a liver-specific gene: hormone-induced transcription factor binding to constitutively open chromatin by Zimmermann, P L, Pierreux, C E, Rigaud, G, Rousseau, G G, Lemaigre, F P

“…Transcription from the liver promoter of a 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2) gene depends on the presence of glucocorticoids that…”
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Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors by Clotman, Frédéric, Jacquemin, Patrick, Plumb-Rudewiez, Nicolas, Pierreux, Christophe E, Van der Smissen, Patrick, Dietz, Harry C, Courtoy, Pierre J, Rousseau, Guy G, Lemaigre, Frédéric P

“…During liver development, hepatocytes and biliary cells differentiate from common progenitors called hepatoblasts. The factors that control hepatoblast fate…”
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The Transcription Factor Hepatocyte Nuclear Factor-6 Controls the Development of Pancreatic Ducts in the Mouse by Pierreux, Christophe E., Poll, Aurélie V., Kemp, Caroline R., Clotman, Frédéric, Maestro, Miguel A., Cordi, Sabine, Ferrer, Jorge, Leyns, Luc, Rousseau, Guy G., Lemaigre, Frédéric P.

“…Background & Aims: A number of hereditary polycystic diseases are associated with formation of cysts within the pancreatic ducts. The cysts result from…”
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Raf induces TGFβ production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells by Lehmann, Kerstin, Janda, Elzbieta, Pierreux, Christophe E., Rytömaa, Marjatta, Schulze, Almut, McMahon, Martin, Hill, Caroline S., Beug, Hartmut, Downward, Julian

“…c-Raf-1 is a major effector of Ras proteins, responsible for activation of the ERK MAP kinase pathway and a critical regulator of both normal growth and…”
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Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas by Maestro, Miguel A., Boj, Sylvia F., Luco, Reini F., Pierreux, Christophe E., Cabedo, Judit, Servitja, Joan M., German, Michael S., Rousseau, Guy G., Lemaigre, Frédéric P., Ferrer, Jorge

“…During pancreatic organogenesis endocrine cells arise from non self-renewing progenitors that express Ngn3. The precursors that give rise to Ngn3+ cells are…”
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Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells by Lehmann, K, Janda, E, Pierreux, C E, Rytömaa, M, Schulze, A, McMahon, M, Hill, C S, Beug, H, Downward, J

“…c-Raf-1 is a major effector of Ras proteins, responsible for activation of the ERK MAP kinase pathway and a critical regulator of both normal growth and…”
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Transcription factor HNF‐6/OC‐1 inhibits the stimulation of the HNF‐3α/Foxa1 gene by TGF‐β in mouse liver by Plumb‐Rudewiez, Nicolas, Clotman, Frédéric, Strick‐Marchand, Hélène, Pierreux, Christophe E., Weiss, Mary C., Rousseau, Guy G., Lemaigre, Frédéric P.

“…A network of liver‐enriched transcription factors controls differentiation and morphogenesis of the liver. These factors interact via direct, feedback, and…”
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Plasticity of a transcriptional regulation network among alpha‐proteobacteria is supported by the identification of CtrA targets in Brucella abortus by Bellefontaine, Anne‐Flore, Pierreux, Christophe E., Mertens, Pascal, Vandenhaute, Jean, Letesson, Jean‐Jacques, Bolle, Xavier De

“…Summary CtrA is a master response regulator found in many alpha‐proteobacteria. In Caulobacter crescentus and Sinorhizobium meliloti, this regulator is…”
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Shh-dependent differentiation of intestinal tissue from embryonic pancreas by activin A by van Eyll, Jonathan M, Pierreux, Christophe E, Lemaigre, Frédéric P, Rousseau, Guy G

“…The pancreas develops from the endoderm to give rise to ducts, acini and islets of Langerhans. This process involves extracellular signals of the Transforming…”
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The Transcription Factor Hepatocyte Nuclear Factor-6/Onecut-1 Controls the Expression of Its Paralog Onecut-3 in Developing Mouse Endoderm by Pierreux, Christophe E., Vanhorenbeeck, Vinciane, Jacquemin, Patrick, Lemaigre, Frédéric P., Rousseau, Guy G.

“…During development, the endoderm gives rise to several organs, including the pancreas and liver. This differentiation process requires spatial and temporal…”
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