Search Results - "Pierre Dayer"

Drug-Induced Long QT in Adult Psychiatric Inpatients: The 5-Year Cross-Sectional ECG Screening Outcome in Psychiatry Study by R. Girardin, François, Gex-Fabry, Marianne, Berney, Patricia, Shah, Dipen, Gaspoz, Jean-Michel, Dayer, Pierre

“…Routine electrocardiograms of 6,790 patients admitted to a Swiss public psychiatric hospital over 5 years showed the likelihood of a long QT interval increases…”
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Patented drug extension strategies on healthcare spending: a cost-evaluation analysis by Vernaz, Nathalie, Haller, Guy, Girardin, François, Huttner, Benedikt, Combescure, Christophe, Dayer, Pierre, Muscionico, Daniel, Salomon, Jean-Luc, Bonnabry, Pascal

“…Drug manufacturers have developed "evergreening" strategies to compete with generic medication after patent termination. These include marketing of slightly…”
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CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis by VUILLEUMIER, Nicolas, ROSSIER, Michel F, CHIAPPE, Alberto, DEGOUMOIS, Florence, DAYER, Pierre, MERMILLOD, Bernadette, NICOD, Laurent, DESMEULES, Jules, HOCHSTRASSER, Denis

“…To determine whether pharmacogenetic tests such as N-acetyltransferase 2 (NAT2) and cytochrome P450 2E1 (CYP2E1) genotyping are useful in identifying patients…”
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Pharmacokinetic Interaction Between Prasugrel and Ritonavir in Healthy Volunteers by Ancrenaz, Virginie, Déglon, Julien, Samer, Caroline, Staub, Christian, Dayer, Pierre, Daali, Youssef, Desmeules, Jules

“…The new anti‐aggregating agent prasugrel is bioactivated by cytochromes P450 (CYP) 3A and 2B6. Ritonavir is a potent CYP3A inhibitor and was shown in vitro as…”
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Impact of Advance Directives and a Health Care Proxy on Doctors' Decisions: A Randomized Trial by Escher, Monica, MD, Perneger, Thomas V., MD, Rudaz, Sandrine, MA, Dayer, Pierre, MD, Perrier, Arnaud, MD

“…Abstract Context Advance directives or proxy designations are widely recommended, but how they affect doctors' decision making is not well known. Objectives…”
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Doctors' Decisions When Faced With Contradictory Patient Advance Directives and Health Care Proxy Opinion: A Randomized Vignette-Based Study by Escher, Monica, MD, Perrier, Arnaud, MD, Rudaz, Sandrine, MA, Dayer, Pierre, MD, Perneger, Thomas V., MD

“…Abstract Context Sometimes a written advance directive contradicts the opinion of a health care proxy. How this affects doctors' decision making is unknown…”
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Role of P‐glycoprotein in the Uptake/Efflux Transport of Oral Vitamin K Antagonists and Rivaroxaban through the Caco‐2 Cell Model by Gschwind, Liliane, Rollason, Victoria, Daali, Youssef, Bonnabry, Pascal, Dayer, Pierre, Desmeules, Jules Alexandre

“…Vitamin K antagonists (VKAs) are prescribed worldwide and remain the oral anticoagulant of choice. These drugs are characterized by a narrow therapeutic index…”
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Pharmacogenetics of analgesics: toward the individualization of prescription by Rollason, Victoria, Samer, Caroline, Piguet, Valerie, Dayer, Pierre, Desmeules, Jules

“…The use of analgesics is based on the empiric administration of a given drug with clinical monitoring for efficacy and toxicity. However, individual responses…”
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Providing Quality Therapeutics in Switzerland: Role of the Stakeholders and Recent Incentives for Further Improvements by Besson, Marie, MD, Samer, Caroline, MD, PharmD, Rollason, Victoria, PharmD, Dayer, Pierre, MD, Desmeules, Jules, MD

“…Abstract Quality therapeutics play an important role in Switzerland’s health care and economy. Switzerland holds a key position in the world of research and…”
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Transcriptional regulation of CYP2C19 and its role in altered enzyme activity by Uppugunduri, Chakradhara Rao S, Daali, Youssef, Desmeules, Jules, Dayer, Pierre, Krajinovic, Maja, Ansari, Marc

“…Cytochrome P450 2C19 (CYP2C19) is involved in the metabolism of several drugs that are currently in clinical use. The gene encoding CYP2C19 is polymorphic with…”
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Monitoring white blood cell count in adult patients with schizophrenia who are taking clozapine: a cost-effectiveness analysis by Girardin, François R, Dr, Poncet, Antoine, MSc, Blondon, Marc, MD, Rollason, Victoria, PhD, Vernaz, Nathalie, PhD, Chalandon, Yves, Prof, Dayer, Pierre, Prof, Combescure, Christophe, PhD

“…Summary Background Long-term monitoring of white blood cell count is compulsory in patients taking clozapine, although the incidence of drug-induced…”
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Pharmacokinetic and Pharmacodynamic Properties of Buprenorphine After a Single Intravenous Administration in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study by Escher, Monica, MD, Daali, Youssef, PharmD,PhD, Chabert, Jocelyne, PhD, Hopfgartner, Gérard, PhD, Dayer, Pierre, MD, Desmeules, Jules, MD

“…Abstract Background: Buprenorphine is used as an analgesic for postoperative and chronic pain. The usual sublingual dose is 0.2 to 0.8 mg, and the usual…”
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Validation of the simplified UVB model to assess the pharmacodynamics of analgesics in healthy human volunteers by Ing Lorenzini, Kuntheavy, Besson, Marie, Daali, Youssef, Salomon, Denis, Dayer, Pierre, Desmeules, Jules

“…A pharmacokinetic/pharmacodynamic, randomized, crossover, placebo-controlled study was conducted in healthy human volunteers with the primary objective of…”
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A simplified analytical method for a phenotyping cocktail of major CYP450 biotransformation routes by Jerdi, Mallorie Clement, Daali, Youssef, Oestreicher, Mitsuko Kondo, Cherkaoui, Samir, Dayer, Pierre

“…An efficient, fast and reliable analytical method was developed for the simultaneous evaluation of the activities of five major human drug metabolising…”
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A new genetic defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin by Ferguson, R J, De Morais, S M, Benhamou, S, Bouchardy, C, Blaisdell, J, Ibeanu, G, Wilkinson, G R, Sarich, T C, Wright, J M, Dayer, P, Goldstein, J A

“…The 4'-hydroxylation of the S-enantiomer of the anticonvulsant drug mephenytoin exhibits a genetic polymorphism in humans. This polymorphism shows marked…”
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Two-dimensional liquid chromatography–ion trap mass spectrometry for the simultaneous determination of ketorolac enantiomers and paracetamol in human plasma by Ing-Lorenzini, Kuntheavy R., Desmeules, Jules A., Besson, Marie, Veuthey, Jean-Luc, Dayer, Pierre, Daali, Youssef

“…A bioanalytical method was developed for the simultaneous determination of paracetamol and ketorolac enantiomers in human plasma using two-dimensional liquid…”
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In vivo inhibition profile of cytochrome P450TB (CYP2C9) by (+/-)-fluvastatin by Transon, C, Leemann, T, Vogt, N, Dayer, P

“…(+/-)-Fluvastatin is a synthetic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that selectively and competitively inhibits P450TB…”
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Metabolic genetic polymorphisms and susceptibility to lung cancer by Bouchardy, Christine, Benhamou, Simone, Jourenkova, Nadejda, Dayer, Pierre, Hirvonen, Ari

“…Activity of some enzymes implicated in the metabolism of tobacco carcinogens presents a great variability between individuals due to the existence of a…”
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Glutathione S-Transferase GSTM3 and GSTP1 Genotypes and Larynx Cancer Risk by Jourenkova-Mironova, N, Voho, A, Bouchardy, C, Wikman, H, Dayer, P, Benhamou, S, Hirvonen, A

“…Glutathione S -transferases (GSTs) are involved in detoxification of reactive metabolites of carcinogens and, therefore, could be potentially important in…”
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Admission to intensive care: A qualitative study of triage and its determinants by Escher, Monica, Cullati, Stéphane, Hudelson, Patricia, Nendaz, Mathieu, Ricou, Bara, Perneger, Thomas, Dayer, Pierre

“…Objective To examine physicians’ decision making and its determinants about admission to intensive care. Data Sources/Study Setting ICU physicians (n = 12) and…”
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