Search Results - "Piero Marchetti"

Encapsulated islets for diabetes therapy: History, current progress, and critical issues requiring solution by Scharp, David W., Marchetti, Piero

“…Insulin therapy became a reality in 1921 dramatically saving lives of people with diabetes, but not protecting them from long-term complications. Clinically…”
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Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource by Marchetti, Piero, Suleiman, Mara, Marselli, Lorella

“…Direct in vivo assessment of pancreatic islet-cells for the study of the pathophysiology of diabetes in humans is hampered by anatomical and technological…”
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A circular RNA generated from an intron of the insulin gene controls insulin secretion by Stoll, Lisa, Rodríguez-Trejo, Adriana, Guay, Claudiane, Brozzi, Flora, Bayazit, Mustafa Bilal, Gattesco, Sonia, Menoud, Véronique, Sobel, Jonathan, Marques, Ana Claudia, Venø, Morten Trillingsgaard, Esguerra, Jonathan Lou S., Barghouth, Mohammad, Suleiman, Mara, Marselli, Lorella, Kjems, Jørgen, Eliasson, Lena, Renström, Erik, Bouzakri, Karim, Pinget, Michel, Marchetti, Piero, Regazzi, Romano

“…Fine-tuning of insulin release from pancreatic β-cells is essential to maintain blood glucose homeostasis. Here, we report that insulin secretion is regulated…”
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Phosphoproteomics Reveals the GSK3-PDX1 Axis as a Key Pathogenic Signaling Node in Diabetic Islets by Sacco, Francesca, Seelig, Anett, Humphrey, Sean J., Krahmer, Natalie, Volta, Francesco, Reggio, Alessio, Marchetti, Piero, Gerdes, Jantje, Mann, Matthias

“…Progressive decline of pancreatic beta cell function is central to the pathogenesis of type 2 diabetes. Protein phosphorylation regulates glucose-stimulated…”
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Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose by Johnston, Natalie R., Mitchell, Ryan K., Haythorne, Elizabeth, Pessoa, Maria Paiva, Semplici, Francesca, Ferrer, Jorge, Piemonti, Lorenzo, Marchetti, Piero, Bugliani, Marco, Bosco, Domenico, Berishvili, Ekaterine, Duncanson, Philip, Watkinson, Michael, Broichhagen, Johannes, Trauner, Dirk, Rutter, Guy A., Hodson, David J.

“…The arrangement of β cells within islets of Langerhans is critical for insulin release through the generation of rhythmic activity. A privileged role for…”
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SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β -Cells and in the Human Pancreas Microvasculature by Fignani, Daniela, Licata, Giada, Brusco, Noemi, Nigi, Laura, Grieco, Giuseppina E, Marselli, Lorella, Overbergh, Lut, Gysemans, Conny, Colli, Maikel L, Marchetti, Piero, Mathieu, Chantal, Eizirik, Decio L, Sebastiani, Guido, Dotta, Francesco

“…Increasing evidence demonstrated that the expression of Angiotensin I-Converting Enzyme type 2 (ACE2) is a necessary step for SARS-CoV-2 infection…”
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Insulin Autoimmune Syndrome (Hirata Disease): A Comprehensive Review Fifty Years After Its First Description by Cappellani, Daniele, Macchia, Enrico, Falorni, Alberto, Marchetti, Piero

“…Insulin autoimmune syndrome (IAS), also named Hirata's disease, is a rare condition characterized by hypoglycemic episodes due to the presence of high titers…”
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Optical Nanoscopy of Cytokine-Induced Structural Alterations of the Endoplasmic Reticulum and Golgi Apparatus in Insulin-Secreting Cells by Pugliese, Licia Anna, De Lorenzi, Valentina, Tesi, Marta, Marchetti, Piero, Cardarelli, Francesco

“…Pro-inflammatory cytokines play a role in the failure of β cells in type 1 and type 2 diabetes. While existing data from 'omics' experiments allow for some…”
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Targeting GLP-1 receptor trafficking to improve agonist efficacy by Jones, Ben, Buenaventura, Teresa, Kanda, Nisha, Chabosseau, Pauline, Owen, Bryn M., Scott, Rebecca, Goldin, Robert, Angkathunyakul, Napat, Corrêa Jr, Ivan R., Bosco, Domenico, Johnson, Paul R., Piemonti, Lorenzo, Marchetti, Piero, Shapiro, A. M. James, Cochran, Blake J., Hanyaloglu, Aylin C., Inoue, Asuka, Tan, Tricia, Rutter, Guy A., Tomas, Alejandra, Bloom, Stephen R.

“…Glucagon-like peptide-1 receptor (GLP-1R) activation promotes insulin secretion from pancreatic beta cells, causes weight loss, and is an important…”
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Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells by Demine, Stéphane, Schiavo, Andrea Alex, Marín-Cañas, Sandra, Marchetti, Piero, Cnop, Miriam, Eizirik, Decio L

“…Adult human pancreatic beta cells are the "gold standard" for studies on diabetes pathogenesis, but their use is limited by insufficient availability and…”
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β-Cell Pathophysiology: A Review of Advanced Optical Microscopy Applications by Ferri, Gianmarco, Pesce, Luca, Tesi, Marta, Marchetti, Piero, Cardarelli, Francesco

“…β-cells convert glucose (input) resulting in the controlled release of insulin (output), which in turn has the role to maintain glucose homeostasis. β-cell…”
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RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate by CNOP, Miriam, ABDULKARIM, Baroj, BUGLIANI, Marco, LADRIERE, Laurence, MARSELLI, Lorella, MCCARTHY, Mark I, MARCHETTI, Piero, SAMMETH, Michael, EIZIRIK, Décio L, BOTTU, Guy, CUNHA, Daniel A, IGOILLO-ESTEVE, Mariana, MASINI, Matilde, TURATSINZE, Jean-Valery, GRIEBEL, Thasso, VILLATE, Olatz, SANTIN, Izortze

“…Pancreatic β-cell dysfunction and death are central in the pathogenesis of type 2 diabetes (T2D). Saturated fatty acids cause β-cell failure and contribute to…”
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The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines by Eizirik, Décio L, Sammeth, Michael, Bouckenooghe, Thomas, Bottu, Guy, Sisino, Giorgia, Igoillo-Esteve, Mariana, Ortis, Fernanda, Santin, Izortze, Colli, Maikel L, Barthson, Jenny, Bouwens, Luc, Hughes, Linda, Gregory, Lorna, Lunter, Gerton, Marselli, Lorella, Marchetti, Piero, McCarthy, Mark I, Cnop, Miriam

“…Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic beta cells are killed by infiltrating immune cells and by cytokines released by these cells…”
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An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells by Colli, Maikel L., Ramos-Rodríguez, Mireia, Nakayasu, Ernesto S., Alvelos, Maria I., Lopes, Miguel, Hill, Jessica L. E., Turatsinze, Jean-Valery, Coomans de Brachène, Alexandra, Russell, Mark A., Raurell-Vila, Helena, Castela, Angela, Juan-Mateu, Jonàs, Webb-Robertson, Bobbie-Jo M., Krogvold, Lars, Dahl-Jorgensen, Knut, Marselli, Lorella, Marchetti, Piero, Richardson, Sarah J., Morgan, Noel G., Metz, Thomas O., Pasquali, Lorenzo, Eizirik, Décio L.

“…Interferon-α (IFNα), a type I interferon, is expressed in the islets of type 1 diabetic individuals, and its expression and signaling are regulated by T1D…”
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YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress by De Franco, Elisa, Lytrivi, Maria, Ibrahim, Hazem, Montaser, Hossam, Wakeling, Matthew N, Fantuzzi, Federica, Patel, Kashyap, Demarez, Céline, Cai, Ying, Igoillo-Esteve, Mariana, Cosentino, Cristina, Lithovius, Väinö, Vihinen, Helena, Jokitalo, Eija, Laver, Thomas W, Johnson, Matthew B, Sawatani, Toshiaki, Shakeri, Hadis, Pachera, Nathalie, Haliloglu, Belma, Ozbek, Mehmet Nuri, Unal, Edip, Yıldırım, Ruken, Godbole, Tushar, Yildiz, Melek, Aydin, Banu, Bilheu, Angeline, Suzuki, Ikuo, Flanagan, Sarah E, Vanderhaeghen, Pierre, Senée, Valérie, Julier, Cécile, Marchetti, Piero, Eizirik, Decio L, Ellard, Sian, Saarimäki-Vire, Jonna, Otonkoski, Timo, Cnop, Miriam, Hattersley, Andrew T

“…Neonatal diabetes is caused by single gene mutations reducing pancreatic β cell number or impairing β cell function. Understanding the genetic basis of rare…”
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Machine-learning-guided recognition of α and β cells from label-free infrared micrographs of living human islets of Langerhans by Azzarello, Fabio, Carli, Francesco, De Lorenzi, Valentina, Tesi, Marta, Marchetti, Piero, Beltram, Fabio, Raimondi, Francesco, Cardarelli, Francesco

“…Human islets of Langerhans are composed mostly of glucagon-secreting α cells and insulin-secreting β cells closely intermingled one another. Current methods…”
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Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity by Oshima, Masaya, Pechberty, Séverine, Bellini, Lara, Göpel, Sven O., Campana, Mélanie, Rouch, Claude, Dairou, Julien, Cosentino, Cristina, Fantuzzi, Federica, Toivonen, Sanna, Marchetti, Piero, Magnan, Christophe, Cnop, Miriam, Le Stunff, Hervé, Scharfmann, Raphaël

“…Aims/hypothesis During the onset of type 2 diabetes, excessive dietary intake of saturated NEFA and fructose lead to impaired insulin production and secretion…”
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Unveiling nanoscale optical signatures of cytokine-induced β-cell dysfunction by Pugliese, Licia Anna, De Lorenzi, Valentina, Bernardi, Mario, Ghignoli, Samuele, Tesi, Marta, Marchetti, Piero, Pesce, Luca, Cardarelli, Francesco

“…Pro-inflammatory cytokines contribute to β-cell failure in both Type-1 and Type-2 Diabetes. Data collected so far allowed to dissect the genomic,…”
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Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes by Marselli, Lorella, Thorne, Jeffrey, Dahiya, Sonika, Sgroi, Dennis C, Sharma, Arun, Bonner-Weir, Susan, Marchetti, Piero, Weir, Gordon C

“…Changes in gene expression in pancreatic beta-cells from type 2 diabetes (T2D) should provide insights into their abnormal insulin secretion and turnover…”
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Palmitate activates autophagy in INS-1E β-cells and in isolated rat and human pancreatic islets by Martino, Luisa, Masini, Matilde, Novelli, Michela, Beffy, Pascale, Bugliani, Marco, Marselli, Lorella, Masiello, Pellegrino, Marchetti, Piero, De Tata, Vincenzo

“…We have investigated the in vitro effects of increased levels of glucose and free fatty acids on autophagy activation in pancreatic beta cells. INS-1E cells…”
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