Search Results - "Pieren, Daan K J"

Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection by Pieren, Daan K. J., Kuguel, Sebastián G., Rosado, Joel, Robles, Alba G., Rey-Cano, Joan, Mancebo, Cristina, Esperalba, Juliana, Falcó, Vicenç, Buzón, María J., Genescà, Meritxell

“…Resident memory T cells (T RM ) present at the respiratory tract may be essential to enhance early SARS-CoV-2 viral clearance, thus limiting viral infection…”
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The adaptive immune system in early life: The shift makes it count by Pieren, Daan K. J., Boer, Mardi C., de Wit, Jelle

“…Respiratory infectious diseases encountered early in life may result in life-threatening disease in neonates, which is primarily explained by the relatively…”
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Response kinetics reveal novel features of ageing in murine T cells by Pieren, Daan K. J., Smits, Noortje A. M., van de Garde, Martijn D. B., Guichelaar, Teun

“…The impact of ageing on the immune system results in defects in T cell responsiveness. The search for ageing hallmarks has been challenging due to the complex…”
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Co-Expression of TIGIT and Helios Marks Immunosenescent CD8 + T Cells During Aging by Pieren, Daan K J, Smits, Noortje A M, Postel, Rimke J, Kandiah, Vinitha, de Wit, Jelle, van Beek, Josine, van Baarle, Debbie, Guichelaar, Teun

“…Aging leads to alterations in the immune system that result in ineffective responsiveness against pathogens. Features of this process, collectively known as…”
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Long Lasting Antibodies From Convalescent Pertussis Patients Induce ROS Production and Bacterial Killing by Human Neutrophils by Kroes, Michiel M, van Vliet, Lars C, Jacobi, Ronald H J, Kuipers, Betsy, Pieren, Daan K J, Miranda-Bedate, Alberto, van Els, Cécile A C M, Pinelli, Elena

“…Pertussis is a respiratory infection caused by the Gram-negative bacterium . Despite high vaccination coverage this disease remains a public health concern…”
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Diversity of aging of the immune system classified in the cotton rat (Sigmodon hispidus) model of human infectious diseases by Guichelaar, Teun, van Erp, Elisabeth A., Hoeboer, Jeroen, Smits, Noortje A.M., van Els, Cécile A.C.M., Pieren, Daan K.J., Luytjes, Willem

“…Susceptibility and declined resistance to human pathogens like respiratory syncytial virus (RSV) at old age is well represented in the cotton rat (Sigmodon…”
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Reduced Bordetella pertussis-specific CD4+ T-Cell Responses at Older Age by Lambert, Eleonora E., van Twillert, Inonge, Beckers, Lisa, Poelen, Martien C. M., Han, Wanda G. H., Pieren, Daan K. J., van Els, Cécile A. C. M.

“…Pertussis, a human-specific respiratory infectious disease caused by the Gram-negative bacterium Bordetella pertussis (Bp), remains endemic with epidemic years…”
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Diminished Pneumococcal-Specific CD4+ T-Cell Response is Associated With Increased Regulatory T Cells at Older Age by He, Samantha W. J., van de Garde, Martijn D. B., Pieren, Daan K. J., Poelen, Martien C. M., Voß, Franziska, Abdullah, Mohammed R., Hammerschmidt, Sven, van Els, Cécile A. C. M.

“…Respiratory infection caused by Streptococcus pneumoniae is a leading cause of morbidity and mortality in older adults. Acquired CD4 + T cell mechanism are…”
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Comparison of the PRNT and an immune fluorescence assay in yellow fever vaccinees receiving immunosuppressive medication by Wieten, Rosanne W, Jonker, Emile F.F, Pieren, Daan K.J, Hodiamont, Caspar J, van Thiel, Pieter P.A.M, van Gorp, Eric C.M, de Visser, Adriëtte W, Grobusch, Martin P, Visser, Leo G, Goorhuis, Abraham

“…Highlights • The 17 D Yellow Fever vaccination yields an effective immune response in immune-compromised patients. • In measuring post vaccination…”
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Targeting HIV persistence in the tissue by Pieren, Daan K J, Benítez-Martínez, Aleix, Genescà, Meritxell

“…The complex nature and distribution of the HIV reservoir in tissue of people with HIV remains one of the major obstacles to achieve the elimination of HIV…”
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Regulatory KIR+RA+ T cells accumulate with age and are highly activated during viral respiratory disease by Pieren, Daan K. J., Smits, Noortje A. M., Hoeboer, Jeroen, Kandiah, Vinitha, Postel, Rimke J., Mariman, Rob, Beek, Josine, Baarle, Debbie, Wit, Jelle, Guichelaar, Teun

“…Severe respiratory viral infectious diseases such as influenza and COVID‐19 especially affect the older population. This is partly ascribed to diminished CD8+…”
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Compromised DNA Repair Promotes the Accumulation of Regulatory T Cells With an Aging-Related Phenotype and Responsiveness by Pieren, Daan K J, Smits, Noortje A M, Imholz, Sandra, Nagarajah, Bhawani, van Oostrom, Conny T, Brandt, Renata M C, Vermeij, Wilbert P, Dollé, Martijn E T, Guichelaar, Teun

“…Decline of immune function during aging has in part been ascribed to the accumulation of regulatory T cells (Tregs) and decreased T-cell responses with age…”
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