Search Results - "Pierdominici, Marina"

Editorial: Sex Hormones and Gender Differences in Immune Responses by Ortona, Elena, Pierdominici, Marina, Rider, Virginia

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The role of vitamin D in autoimmune diseases: could sex make the difference? by Dupuis, Maria Luisa, Pagano, Maria Teresa, Pierdominici, Marina, Ortona, Elena

“…Over the last decades, a central role for vitamin D in immune modulation has been well established. The active form of vitamin D, i.e., 1,25-dihydroxyvitamin…”
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Human Monocyte-Derived Dendritic Cells Are the Pharmacological Target of the Immunosuppressant Flavonoid Silibinin by Pagano, Maria Teresa, Fecchi, Katia, Pierdominici, Marina, Ortona, Elena, Peruzzu, Daniela

“…Silibinin, a natural polyphenolic flavonoid, is known to possess anti-inflammatory, anticancer, antioxidant, and immunomodulatory properties. However, the…”
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Anti-Inflammatory Effects of 1,25(OH)2D/Calcitriol in T Cell Immunity: Does Sex Make a Difference? by Peruzzu, Daniela, Dupuis, Maria Luisa, Pierdominici, Marina, Fecchi, Katia, Gagliardi, Maria Cristina, Ortona, Elena, Pagano, Maria Teresa

“…Hypovitaminosis D is involved in various inflammatory, infectious and autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. Moreover, the…”
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The Natural Agonist of Estrogen Receptor β Silibinin Plays an Immunosuppressive Role Representing a Potential Therapeutic Tool in Rheumatoid Arthritis by Dupuis, Maria Luisa, Conti, Fabrizio, Maselli, Angela, Pagano, Maria Teresa, Ruggieri, Anna, Anticoli, Simona, Fragale, Alessandra, Gabriele, Lucia, Gagliardi, Maria Cristina, Sanchez, Massimo, Ceccarelli, Fulvia, Alessandri, Cristiano, Valesini, Guido, Ortona, Elena, Pierdominici, Marina

“…Estrogens, in particular 17β-estradiol (E2), have a strong influence on the immune system and also affect pathological conditions such as autoimmune diseases…”
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The Natural Estrogen Receptor Beta Agonist Silibinin as a Promising Therapeutic Tool in Diffuse Large B-cell Lymphoma by Ortona, Elena, Locatelli, Silvia L, Pagano, Maria Teresa, Ascione, Barbara, Careddu, Giuseppa, Dupuis, Maria Luisa, Marconi, Matteo, Carlo-Stella, Carmelo, Malorni, Walter, Matarrese, Paola, Pierdominici, Marina

“…About 40% of patients with diffuse large cell lymphoma (DLBCL) still have a poor prognosis. Additionally, DLBCL patients treated with doxorubicin are at risk…”
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CD4 T lymphocyte autophagy is upregulated in the salivary glands of primary Sjögren's syndrome patients and correlates with focus score and disease activity by Alessandri, Cristiano, Ciccia, Francesco, Priori, Roberta, Astorri, Elisa, Guggino, Giuliana, Alessandro, Riccardo, Rizzo, Aroldo, Conti, Fabrizio, Minniti, Antonina, Barbati, Cristiana, Vomero, Marta, Pendolino, Monica, Finucci, Annacarla, Ortona, Elena, Colasanti, Tania, Pierdominici, Marina, Malorni, Walter, Triolo, Giovanni, Valesini, Guido

“…Primary Sjögren's syndrome (pSS) is a common chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands and peripheral lymphocyte…”
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Distinct Blood and Visceral Adipose Tissue Regulatory T Cell and Innate Lymphocyte Profiles Characterize Obesity and Colorectal Cancer by Donninelli, Gloria, Del Cornò, Manuela, Pierdominici, Marina, Scazzocchio, Beatrice, Varì, Rosaria, Varano, Barbara, Pacella, Ilenia, Piconese, Silvia, Barnaba, Vincenzo, D'Archivio, Massimo, Masella, Roberta, Conti, Lucia, Gessani, Sandra

“…Visceral adipose tissue (VAT) is a main site where metabolic and immunologic processes interplay to regulate, at local and systemic level, the inflammatory…”
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Dietary Habits, Physical Activity and Body Mass Index in Transgender and Gender Diverse Adults in Italy: A Voluntary Sampling Observational Study by Santangelo, Carmela, Marconi, Matteo, Ruocco, Angela, Ristori, Jiska, Bonadonna, Stefania, Pivonello, Rosario, Meriggiola, Maria Cristina, Lombardo, Francesco, Motta, Giovanna, Crespi, Chiara Michela, Mosconi, Maddalena, Oppo, Alessandro, Federici, Silvia, Bruno, Luca, Verde, Nunzia, Lami, Alessandra, Bologna, Emanuela, Varì, Rosaria, Pagano, Maria Teresa, Giordani, Luciana, Matarrese, Paola, Chiarotti, Flavia, Fisher, Alessandra Daphne, Pierdominici, Marina

“…Transgender and gender-diverse (TGD) individuals continue to experience harassment and discrimination across various aspects of life, significantly impacting…”
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mTOR signaling and metabolic regulation of T cells: new potential therapeutic targets in autoimmune diseases by Pierdominici, Marina, Vacirca, Davide, Delunardo, Federica, Ortona, Elena

“…The mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase that forms a multisubunit complex with numerous protein partners and it regulates…”
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Sex Differences in Response to TNF-Inhibiting Drugs in Patients With Spondyloarthropathies or Inflammatory Bowel Diseases by Laganà, Bruno, Zullo, Angelo, Scribano, Maria Lia, Chimenti, Maria Sole, Migliore, Alberto, Picchianti Diamanti, Andrea, Lorenzetti, Roberto, Scolieri, Palma, Ridola, Lorenzo, Ortona, Elena, Pierdominici, Marina, Bruzzese, Vincenzo

“…Spondyloarthritis (SpA) and inflammatory bowel diseases (IBD) are chronic inflammatory diseases characterized by an aberrant immune response and inflammation…”
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Evaluating the impact of distance learning on gender-affirming healthcare competence: knowledge acquisition and satisfaction among healthcare professionals in Italy by Favazzi, Ughetta Maria, Marconi, Matteo, Carbone, Pietro, Guerrera, Debora, Ruocco, Angela, Manoli, Martina, Molinaro, Francesca, Regini, Federica Maria, Vittozzi, Andrea, Mazzaccara, Alfonso, Pierdominici, Marina

“…Transgender and gender diverse (TGD) individuals face significant healthcare barriers, with one of the most critical being the inadequate knowledge and skills…”
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Predicting respiratory failure in patients infected by SARS-CoV-2 by admission sex-specific biomarkers by Pagano, Maria Teresa, Peruzzu, Daniela, Busani, Luca, Pierdominici, Marina, Ruggieri, Anna, Antinori, Andrea, D'Offizi, Gianpiero, Petrosillo, Nicola, Palmieri, Fabrizio, Piselli, Pierluca, Cicalini, Stefania, Notari, Stefania, Nicastri, Emanuele, Agrati, Chiara, Ippolito, Giuseppe, Vaia, Francesco, Gagliardi, Maria Cristina, Capobianchi, Maria Rosaria, Ortona, Elena

“…Several biomarkers have been identified to predict the outcome of COVID-19 severity, but few data are available regarding sex differences in their predictive…”
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Autoantibodies to estrogen receptor α in systemic sclerosis (SSc) as pathogenetic determinants and markers of progression by Giovannetti, Antonello, Maselli, Angela, Colasanti, Tania, Rosato, Edoardo, Salsano, Felice, Pisarri, Simonetta, Mezzaroma, Ivano, Malorni, Walter, Ortona, Elena, Pierdominici, Marina

“…Systemic sclerosis (SSc) is a multisystem autoimmune disease of unknown etiology characterized by inflammation, autoantibody production, and fibrosis. It…”
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Synergy Between Vitamin D and Sex Hormones in Respiratory Functionality of Patients Affected by COVID-19 by Peruzzu, Daniela, Pagano, Maria Teresa, Pierdominici, Marina, Ruggieri, Anna, Antinori, Andrea, D'Offizi, Gianpiero, Petrosillo, Nicola, Palmieri, Fabrizio, Piselli, Pierluca, Boumis, Evangelo, Notari, Stefania, Nicastri, Emanuele, Agrati, Chiara, Ippolito, Giuseppe, Gagliardi, Maria Cristina, Capobianchi, Maria Rosaria, Ortona, Elena

“…The outcome of COVID-19 appears to be influenced by vitamin D status of population. Although epidemiological data indicate that COVID-19 produces more severe…”
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Cell surface estrogen receptor alpha is upregulated during subchronic metabolic stress and inhibits neuronal cell degeneration by Barbati, Cristiana, Pierdominici, Marina, Gambardella, Lucrezia, Malchiodi Albedi, Fiorella, Karas, Richard H, Rosano, Giuseppe, Malorni, Walter, Ortona, Elena

“…In addition to the classical nuclear estrogen receptor, the expression of non-nuclear estrogen receptors localized to the cell surface membrane (mER) has…”
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Gender specific aspects of cell death in the cardiovascular system by Pierdominici, Marina, Ortona, Elena, Franconi, Flavia, Caprio, Massimiliano, Straface, Elisabetta, Malorni, Walter

“…It has become apparent over the past few decades that several factors can determine lethal or sublethal alterations of cardiovascular system cell function such…”
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Autoantibodies Specific to ERα are Involved in Tamoxifen Resistance in Hormone Receptor Positive Breast Cancer by Maselli, Angela, Parlato, Stefania, Puglisi, Rossella, Raggi, Carla, Spada, Massimo, Macchia, Daniele, Pontecorvi, Giada, Iessi, Elisabetta, Pagano, Maria Teresa, Cirulli, Francesca, Gabriele, Lucia, Carè, Alessandra, Vici, Patrizia, Pizzuti, Laura, Barba, Maddalena, Matarrese, Paola, Pierdominici, Marina, Ortona, Elena

“…Tamoxifen resistance is a major hurdle in the treatment of estrogen receptor (ER)-positive breast cancer. The mechanisms of tamoxifen resistance are not fully…”
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Pyrimethamine (2,4-diamino-5-p-chlorophenyl-6-ethylpyrimidine) induces apoptosis of freshly isolated human T lymphocytes, bypassing CD95/Fas molecule but involving its intrinsic pathway by Pierdominici, Marina, Giammarioli, Anna Maria, Gambardella, Lucrezia, De Felice, Marco, Quinti, Isabella, Iacobini, Metello, Carbonari, Maurizio, Malorni, Walter, Giovannetti, Antonello

“…Pyrimethamine (2,4-diamino-5-p-chlorophenyl-6-ethyl-pyrimidine), a folic acid antagonist, may exert, in addition to antiprotozoan effects, immunomodulating…”
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Autoantibodies to estrogen receptors and their involvement in autoimmune diseases and cancer by Ortona, Elena, Pierdominici, Marina, Berstein, Lev

“…•Estrogen receptors play a main role in autoimmunity and hormone-dependent cancer.•Serum ERαAB are present in some autoimmune diseases and behave as clinical…”
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