Search Results - "Pierchala, B A"

Ret Signaling Is Required for Tooth Pulp Innervation during Organogenesis by Donnelly, C.R., Shah, A.A., Suh, E.B., Pierchala, B.A.

“…During organogenesis, the timing and patterning of dental pulp innervation require both chemoattractive and chemorepellent cues for precise spatiotemporal…”
Get full text

An NGF-TrkA-Mediated Retrograde Signal to Transcription Factor CREB in Sympathetic Neurons by Riccio, Antonella, Pierchala, Brian A., Ciarallo, Christopher L., Ginty, David D.

“…Nerve growth factor (NGF) is a neurotrophic factor secreted by cells that are the targets of innervation of sympathetic and some sensory neurons. However, the…”
Get full text

The p75 neurotrophin receptor augments survival signaling in the striatum of pre-symptomatic Q175(WT/HD) mice by Wehner, A B, Milen, A M, Albin, R L, Pierchala, B A

“…Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder characterized by a constellation of motor, cognitive, and psychiatric features…”
Get full text

Phosphatidylinositol 3-Kinase Is Required for the Trophic, But Not the Survival-Promoting, Actions of NGF on Sympathetic Neurons by Tsui-Pierchala, Brian A, Putcha, Girish V, Johnson, Eugene M., Jr

“…Nerve growth factor (NGF) supports target-dependent survival of sympathetic and other neurons during development; however, the NGF-regulated signaling pathways…”
Get full text

The p75 neurotrophin receptor augments survival signaling in the striatum of pre-symptomatic Q175WT/HD mice by Wehner, A.B, Milen, A.A, Albin, R.L, Pierchala, B.A

“…Highlights • Increased survival signaling in pre-symptomatic Q175 mice abolished by p75 deletion. • Q175WT/HD ;p75−/− mice have decreased expression of XIAP,…”
Get full text

c-Src Is Required for Glial Cell Line-Derived Neurotrophic Factor (GDNF) Family Ligand-Mediated Neuronal Survival via a Phosphatidylinositol-3 Kinase (PI-3K)-Dependent Pathway by Encinas, Mario, Tansey, Malu G, Tsui-Pierchala, Brian A, Comella, Joan X, Milbrandt, Jeffrey, Johnson, Eugene M., Jr

“…The glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs), consisting of GDNF, neurturin, persephin, and artemin, signal via a…”
Get full text

Characterization of an NGF-P-TrkA Retrograde-Signaling Complex and Age-Dependent Regulation of TrkA Phosphorylation in Sympathetic Neurons by Tsui-Pierchala, Brian A, Ginty, David D

“…Nerve growth factor (NGF) is a target-derived trophic factor for developing sympathetic and cutaneous sensory neurons. NGF promotes growth and survival of…”
Get full text

The Rapamycin and FKBP12 Target (RAFT) Displays Phosphatidylinositol 4-Kinase Activity (∗) by Sabatini, David M., Pierchala, Brian A., Barrow, Roxanne K., Schell, Michael J., Snyder, Solomon H.

“…The immunosuppressant rapamycin prevents cell cycle progression in several mammalian cell lines and the yeast Saccharomyces cerevisiae. In mammalian cells,…”
Get full text

Glial Cell Line-Derived Neurotrophic Factor-Dependent Recruitment of Ret into Lipid Rafts Enhances Signaling by Partitioning Ret from Proteasome-Dependent Degradation by Pierchala, Brian A, Milbrandt, Jeffrey, Johnson, Eugene M., Jr

“…The receptor tyrosine kinase (RTK) Ret is activated by the formation of a complex consisting of ligands such as glial cell line-derived neurotrophic factor…”
Get full text

Lipid rafts in neuronal signaling and function by Tsui-Pierchala, Brian A, Encinas, Mario, Milbrandt, Jeffrey, Johnson, Eugene M

“…Lipid rafts are plasma membrane microdomains rich in cholesterol and sphingolipids, which provide a particularly ordered lipid environment. Rafts are enriched…”
Get full text

Glial cell line-derived neurotrophic factor and its receptor ret is a novel ligand-receptor complex critical for survival response during podocyte injury by TSUI, Cynthia C, SHANKLAND, Stuart J, PIERCHALA, Brian A

“…Glomerulosclerosis correlates with a reduction in podocyte number that occurs through mechanisms that include apoptosis. Whether glial cell line-derived…”
Get full text

The Long and Short Isoforms of Ret Function as Independent Signaling Complexes by Tsui-Pierchala, Brian A., Ahrens, Rebecca C., Crowder, Robert J., Milbrandt, Jeffrey, Johnson, Eugene M.

“…Ret, the receptor tyrosine kinase for the glial cell line-derived neurotrophic factor family ligands (GFLs), is alternatively spliced to yield at least two…”
Get full text

Nerve Growth Factor Promotes the Survival of Sympathetic Neurons through the Cooperative Function of the Protein Kinase C and Phosphatidylinositol 3-Kinase Pathways by Pierchala, Brian A, Ahrens, Rebecca C, Paden, Andrew J, Johnson, Jr, Eugene M

“…The signaling pathways activated by nerve growth factor (NGF) that account for its ability to promote the survival of neurons are not completely understood…”
Get full text

NGF Utilizes c-Ret Via a Novel GFL-Independent, Inter-RTK Signaling Mechanism to Maintain the Trophic Status of Mature Sympathetic Neurons by Tsui-Pierchala, Brian A., Milbrandt, Jeffrey, Johnson, Eugene M.

“…During postnatal development, sympathetic neurons lose their dependence upon NGF for survival but continue to require NGF for soma and process growth and for…”
Get full text

Neurotrophin and GDNF family ligands promote survival and alter excitotoxic vulnerability of neurons derived from murine embryonic stem cells by Lee, Chul-Sang, Tee, Lee Y., Dusenbery, Susan, Takata, Toshihiro, Golden, Judith P., Pierchala, Brian A., Gottlieb, David I., Johnson, Eugene M., Choi, Dennis W., Joy Snider, B.

“…Embryonic stem (ES) cells are genetically manipulable pluripotential cells that can be differentiated in vitro into neurons, oligodendrocytes, and astrocytes…”
Get full text

An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons by Riccio, A, Pierchala, BA, Ciarallo, CL, Ginty, D D

“…Nerve growth factor (NGF) is a neurotrophic factor secreted by cells that are the targets of innervation of sympathetic and some sensory neurons. However, the…”
Get full text