Search Results - "Pierce, W"

Precipitation in a warming world: Assessing projected hydro-climate changes in California and other Mediterranean climate regions by Polade, Suraj D., Gershunov, Alexander, Cayan, Daniel R., Dettinger, Michael D., Pierce, David W.

“…In most Mediterranean climate (MedClim) regions around the world, global climate models (GCMs) consistently project drier futures. In California, however,…”
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Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes by Ravindra, Neal G, Alfajaro, Mia Madel, Gasque, Victor, Huston, Nicholas C, Wan, Han, Szigeti-Buck, Klara, Yasumoto, Yuki, Greaney, Allison M, Habet, Victoria, Chow, Ryan D, Chen, Jennifer S, Wei, Jin, Filler, Renata B, Wang, Bao, Wang, Guilin, Niklason, Laura E, Montgomery, Ruth R, Eisenbarth, Stephanie C, Chen, Sidi, Williams, Adam, Iwasaki, Akiko, Horvath, Tamas L, Foxman, Ellen F, Pierce, Richard W, Pyle, Anna Marie, van Dijk, David, Wilen, Craig B

“…There are currently limited Food and Drug Administration (FDA)-approved drugs and vaccines for the treatment or prevention of Coronavirus Disease 2019…”
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How degrading! Trapped translation factors get trashed by Ford, Pierce W., Bennett, Eric J.

“…Using small molecules that trap translation factors within translating ribosomes, Gurzeler et al.1 and Oltion et al.2 identify a new branch of the…”
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Bias correction can modify climate model simulated precipitation changes without adverse effect on the ensemble mean by Maurer, E. P, Pierce, D. W

“…When applied to remove climate model biases in precipitation, quantile mapping can in some settings modify the simulated difference in mean precipitation…”
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Residential property value impacts of floodplain buyouts in Charlotte, North Carolina by Pierce Holloway, W., BenDor, Todd K.

“…Floodplain buyouts are an increasingly common policy for mitigating flood risk. Recent research has explored the costs of buyouts and their impacts on…”
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Cand1 Promotes Assembly of New SCF Complexes through Dynamic Exchange of F Box Proteins by Pierce, Nathan W., Lee, J. Eugene, Liu, Xing, Sweredoski, Michael J., Graham, Robert L.J., Larimore, Elizabeth A., Rome, Michael, Zheng, Ning, Clurman, Bruce E., Hess, Sonja, Shan, Shu-ou, Deshaies, Raymond J.

“…The modular SCF (Skp1, cullin, and F box) ubiquitin ligases feature a large family of F box protein substrate receptors that enable recognition of diverse…”
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Improved Bias Correction Techniques for Hydrological Simulations of Climate Change by Pierce, David W., Cayan, Daniel R., Maurer, Edwin P., Abatzoglou, John T., Hegewisch, Katherine C.

“…Global climate model (GCM) output typically needs to be bias corrected before it can be used for climate change impact studies. Three existing bias correction…”
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Structural basis for Notch1 engagement of Delta-like 4 by Luca, Vincent C., Jude, Kevin M., Pierce, Nathan W., Nachury, Maxence V., Fischer, Suzanne, Garcia, K. Christopher

“…An interaction that guides cell fate Notch signaling is important in cell fate determination in mammals. Signaling is initiated when the extracellular domain…”
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Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung by Schupp, Jonas C, Adams, Taylor S, Cosme, Jr, Carlos, Raredon, Micha Sam Brickman, Yuan, Yifan, Omote, Norihito, Poli, Sergio, Chioccioli, Maurizio, Rose, Kadi-Ann, Manning, Edward P, Sauler, Maor, DeIuliis, Giuseppe, Ahangari, Farida, Neumark, Nir, Habermann, Arun C, Gutierrez, Austin J, Bui, Linh T, Lafyatis, Robert, Pierce, Richard W, Meyer, Kerstin B, Nawijn, Martijn C, Teichmann, Sarah A, Banovich, Nicholas E, Kropski, Jonathan A, Niklason, Laura E, Pe'er, Dana, Yan, Xiting, Homer, Robert J, Rosas, Ivan O, Kaminski, Naftali

“…Cellular diversity of the lung endothelium has not been systematically characterized in humans. We provide a reference atlas of human lung endothelial cells…”
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Selecting global climate models for regional climate change studies by Pierce, David W, Barnett, Tim P, Santer, Benjamin D, Gleckler, Peter J

“…Regional or local climate change modeling studies currently require starting with a global climate model, then downscaling to the region of interest. How…”
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Precipitation regime change in Western North America: The role of Atmospheric Rivers by Gershunov, Alexander, Shulgina, Tamara, Clemesha, Rachel E. S., Guirguis, Kristen, Pierce, David W., Dettinger, Michael D., Lavers, David A., Cayan, Daniel R., Polade, Suraj D., Kalansky, Julie, Ralph, F. Martin

“…Daily precipitation in California has been projected to become less frequent even as precipitation extremes intensify, leading to uncertainty in the overall…”
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CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells by Surka, Christine, Jin, Liqing, Mbong, Nathan, Lu, Chin-Chun, Jang, In Sock, Rychak, Emily, Mendy, Derek, Clayton, Thomas, Tindall, Elizabeth, Hsu, Christy, Fontanillo, Celia, Tran, Eileen, Contreras, Adrian, Ng, Stanley W.K., Matyskiela, Mary, Wang, Kai, Chamberlain, Philip, Cathers, Brian, Carmichael, James, Hansen, Joshua, Wang, Jean C.Y., Minden, Mark D., Fan, Jinhong, Pierce, Daniel W., Pourdehnad, Michael, Rolfe, Mark, Lopez-Girona, Antonia, Dick, John E., Lu, Gang

“…A number of clinically validated drugs have been developed by repurposing the CUL4-DDB1-CRBN-RBX1 (CRL4CRBN) E3 ubiquitin ligase complex with molecular glue…”
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Future dryness in the southwest US and the hydrology of the early 21st century drought by Cayan, Daniel R., Das, Tapash, Pierce, David W., Barnett, Tim P., Tyree, Mary, Gershunov, Alexander, MacDonald, Glen M.

“…Recently the Southwest has experienced a spate of dryness, which presents a challenge to the sustainability of current water use by human and natural systems…”
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Letter in response to "Vascular endothelial cadherin shedding is more severe in sepsis patients with severe acute kidney injury" by Pierce, Richard W

“…Yu et al.’s study highlights the clinical utility of VE-cadherin as a potential biomarker of EC injury but falls short of providing mechanistic insight to EC…”
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Ion Implantation of GrapheneToward IC Compatible Technologies by Bangert, U, Pierce, W, Kepaptsoglou, D. M, Ramasse, Q, Zan, R, Gass, M. H, Van den Berg, J. A, Boothroyd, C. B, Amani, J, Hofsäss, H

“…Doping of graphene via low energy ion implantation could open possibilities for fabrication of nanometer-scale patterned graphene-based devices as well as for…”
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Characterization of two classes of small molecule inhibitors of Arp2/3 complex by Pollard, T. D, Nolen, B. J, Tomasevic, N, Russell, A, Pierce, D. W, Jia, Z, McCormick, C. D, Hartman, J, Sakowicz, R

“…Polymerization of actin filaments directed by the actin-related protein (Arp)2/3 complex supports many types of cellular movements. However, questions remain…”
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Sustainable water deliveries from the Colorado River in a changing climate by Barnett, Tim P, Pierce, David W

“…The Colorado River supplies water to 27 million users in 7 states and 2 countries and irrigates over 3 million acres of farmland. Global climate models almost…”
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Multiple stages of evolutionary change in anthrax toxin receptor expression in humans by Choate, Lauren A., Barshad, Gilad, McMahon, Pierce W., Said, Iskander, Rice, Edward J., Munn, Paul R., Lewis, James J., Danko, Charles G.

“…The advent of animal husbandry and hunting increased human exposure to zoonotic pathogens. To understand how a zoonotic disease may have influenced human…”
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The Key Role of Heavy Precipitation Events in Climate Model Disagreements of Future Annual Precipitation Changes in California by Pierce, David W., Cayan, Daniel R., Das, Tapash, Maurer, Edwin P., Miller, Norman L., Bao, Yan, Kanamitsu, M., Yoshimura, Kei, Snyder, Mark A., Sloan, Lisa C., Franco, Guido, Tyree, Mary

“…Climate model simulations disagree on whether future precipitation will increase or decrease over California, which has impeded efforts to anticipate and adapt…”
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Human-Induced Changes in the Hydrology of the Western United States by Barnett, Tim P, Pierce, David W, Hidalgo, Hugo G, Bonfils, Celine, Santer, Benjamin D, Das, Tapash, Bala, Govindasamy, Wood, Andrew W, Nozawa, Toru, Mirin, Arthur A, Cayan, Daniel R, Dettinger, Michael D

“…Observations have shown that the hydrological cycle of the western United States changed significantly over the last half of the 20th century. We present a…”
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