Search Results - "Pierce, Steven E."

DNA strand asymmetry generated by CpG hemimethylation has opposing effects on CTCF binding by Thomas, Stacey L, Xu, Ting-Hai, Carpenter, Brittany L, Pierce, Steven E, Dickson, Bradley M, Liu, Minmin, Liang, Gangning, Jones, Peter A

“…Abstract CpG methylation generally occurs on both DNA strands and is essential for mammalian development and differentiation. Until recently, hemimethylation,…”
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The Parkinson's disease variant rs356182 regulates neuronal differentiation independently from alpha-synuclein by Prahl, Jordan D, Pierce, Steven E, van der Schans, Edwin J C, Coetzee, Gerhard A, Tyson, Trevor

“…One of the most significant risk variants for Parkinson's disease (PD), rs356182, is located at the PD-associated locus near the alpha-synuclein (α-syn)…”
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Parkinson's disease genetic risk in a midbrain neuronal cell line by Pierce, Steven E., Tyson, Trevor, Booms, Alix, Prahl, Jordan, Coetzee, Gerhard A.

“…In genome-wide association studies of complex diseases, many risk polymorphisms are found to lie in non-coding DNA and likely confer risk through…”
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Parkinson’s disease risk enhancers in microglia by Booms, Alix, Pierce, Steven E., van der Schans, Edwin J.C., Coetzee, Gerhard A.

“…Genome-wide association studies have identified thousands of single nucleotide polymorphisms that associate with increased risk for Parkinson’s disease (PD),…”
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Alpha-synuclein negatively controls cell proliferation in dopaminergic neurons by Prahl, Jordan, Pierce, Steven E., Coetzee, Gerhard A., Tyson, Trevor

“…As researchers grapple with the mechanisms and implications of alpha-synuclein (α-syn) in neuropathology, it is often forgotten that the function(s) of α-syn…”
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MCF-7 as a Model for Functional Analysis of Breast Cancer Risk Variants by Booms, Alix, Coetzee, Gerhard A, Pierce, Steven E

“…Breast cancer genetic predisposition is governed by more than 142 loci as revealed by genome-wide association studies (GWAS). The functional contribution of…”
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Post-GWAS knowledge gap: the how, where, and when by Pierce, Steven E., Booms, Alix, Prahl, Jordan, van der Schans, Edwin J. C., Tyson, Trevor, Coetzee, Gerhard A.

“…Genetic risk for complex diseases very rarely reflects only Mendelian-inherited phenotypes where single-gene mutations can be followed in families by linkage…”
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