Search Results - "Pierce, Kerry A."

Accumulation of succinate controls activation of adipose tissue thermogenesis by Mills, Evanna L., Pierce, Kerry A., Jedrychowski, Mark P., Garrity, Ryan, Winther, Sally, Vidoni, Sara, Yoneshiro, Takeshi, Spinelli, Jessica B., Lu, Gina Z., Kazak, Lawrence, Banks, Alexander S., Haigis, Marcia C., Kajimura, Shingo, Murphy, Michael P., Gygi, Steven P., Clish, Clary B., Chouchani, Edward T.

“…Thermogenesis by brown and beige adipose tissue, which requires activation by external stimuli, can counter metabolic disease 1 . Thermogenic respiration is…”
Get full text

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1 by Chouchani, Edward T., Kazak, Lawrence, Jedrychowski, Mark P., Lu, Gina Z., Erickson, Brian K., Szpyt, John, Pierce, Kerry A., Laznik-Bogoslavski, Dina, Vetrivelan, Ramalingam, Clish, Clary B., Robinson, Alan J., Gygi, Steve P., Spiegelman, Bruce M.

“…Uncoupling protein 1 (UCP1)-dependent thermogenesis in brown adipose tissue is supported by a burst of mitochondrial reactive oxygen species upon cold…”
Get full text

Involvement of a gut–retina axis in protection against dietary glycemia-induced age-related macular degeneration by Rowan, Sheldon, Jiang, Shuhong, Korem, Tal, Szymanski, Jedrzej, Chang, Min-Lee, Szelog, Jason, Cassalman, Christa, Dasuri, Kalavathi, McGuire, Christina, Nagai, Ryoji, Du, Xue-Liang, Brownlee, Michael, Rabbani, Naila, Thornalley, Paul J., Baleja, James D., Deik, Amy A., Pierce, Kerry A., Scott, Justin M., Clish, Clary B., Smith, Donald E., Weinberger, Adina, Avnit-Sagi, Tali, Lotan-Pompan, Maya, Segal, Eran, Taylor, Allen

“…Age-related macular degeneration (AMD) is the major cause of blindness in developed nations. AMD is characterized by retinal pigmented epithelial (RPE) cell…”
Get full text

Metabolic Predictors of Incident Coronary Heart Disease in Women by Paynter, Nina P, Balasubramanian, Raji, Giulianini, Franco, Wang, Dong D, Tinker, Lesley F, Gopal, Shuba, Deik, Amy A, Bullock, Kevin, Pierce, Kerry A, Scott, Justin, Martínez-González, Miguel A, Estruch, Ramon, Manson, JoAnn E, Cook, Nancy R, Albert, Christine M, Clish, Clary B, Rexrode, Kathryn M

“…BACKGROUND:Although metabolomic profiling offers promise for the prediction of coronary heart disease (CHD), and metabolic risk factors are more strongly…”
Get full text

Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis by Zhou, Wen, Simic, Petra, Zhou, Iris Y, Caravan, Peter, Vela Parada, Xavier, Wen, Donghai, Washington, Onica L, Shvedova, Maria, Pierce, Kerry A, Clish, Clary B, Mannstadt, Michael, Kobayashi, Tatsuya, Wein, Marc N, Jüppner, Harald, Rhee, Eugene P

“…How phosphate levels are detected in mammals is unknown. The bone-derived hormone fibroblast growth factor 23 (FGF23) lowers blood phosphate levels by reducing…”
Get full text

Metabolic Architecture of Acute Exercise Response in Middle-Aged Adults in the Community by Nayor, Matthew, Shah, Ravi V., Miller, Patricia E., Blodgett, Jasmine B., Tanguay, Melissa, Pico, Alexander R., Murthy, Venkatesh L., Malhotra, Rajeev, Houstis, Nicholas E., Deik, Amy, Pierce, Kerry A., Bullock, Kevin, Dailey, Lucas, Velagaleti, Raghava S., Moore, Stephanie A., Ho, Jennifer E., Baggish, Aaron L., Clish, Clary B., Larson, Martin G., Vasan, Ramachandran S., Lewis, Gregory D.

“…BACKGROUND:Whereas regular exercise is associated with lower risk of cardiovascular disease and mortality, mechanisms of exercise-mediated health benefits…”
Get full text

Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney by Simic, Petra, Kim, Wondong, Zhou, Wen, Pierce, Kerry A, Chang, Wenhan, Sykes, David B, Aziz, Najihah B, Elmariah, Sammy, Ngo, Debby, Pajevic, Paola Divieti, Govea, Nicolas, Kestenbaum, Bryan R, de Boer, Ian H, Cheng, Zhiqiang, Christov, Marta, Chun, Jerold, Leaf, David E, Waikar, Sushrut S, Tager, Andrew M, Gerszten, Robert E, Thadhani, Ravi I, Clish, Clary B, Jüppner, Harald, Wein, Marc N, Rhee, Eugene P

“…Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that controls blood phosphate levels by increasing renal phosphate excretion and reducing…”
Get full text

Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma by Gopal, Raj K., Calvo, Sarah E., Shih, Angela R., Chaves, Frances L., McGuone, Declan, Mick, Eran, Pierce, Kerry A., Li, Yang, Garofalo, Andrea, Van Allen, Eliezer M., Clish, Clary B., Oliva, Esther, Mootha, Vamsi K.

“…Renal oncocytomas are benign tumors characterized by a marked accumulation of mitochondria. We report a combined exome, transcriptome, and metabolome analysis…”
Get full text

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection by Olenchock, Benjamin A., Moslehi, Javid, Baik, Alan H., Davidson, Shawn M., Williams, Jeremy, Gibson, William J., Chakraborty, Abhishek A., Pierce, Kerry A., Miller, Christine M., Hanse, Eric A., Kelekar, Ameeta, Sullivan, Lucas B., Wagers, Amy J., Clish, Clary B., Vander Heiden, Matthew G., Kaelin, William G.

“…Ischemic preconditioning is the phenomenon whereby brief periods of sublethal ischemia protect against a subsequent, more prolonged, ischemic insult. In remote…”
Get full text

Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans by Lennerz, Belinda S., Vafai, Scott B., Delaney, Nigel F., Clish, Clary B., Deik, Amy A., Pierce, Kerry A., Ludwig, David S., Mootha, Vamsi K.

“…Sodium benzoate is a widely used preservative found in many foods and soft drinks. It is metabolized within mitochondria to produce hippurate, which is then…”
Get full text

An exome array study of the plasma metabolome by Rhee, Eugene P., Yang, Qiong, Yu, Bing, Liu, Xuan, Cheng, Susan, Deik, Amy, Pierce, Kerry A., Bullock, Kevin, Ho, Jennifer E., Levy, Daniel, Florez, Jose C., Kathiresan, Sek, Larson, Martin G., Vasan, Ramachandran S., Clish, Clary B., Wang, Thomas J., Boerwinkle, Eric, O’Donnell, Christopher J., Gerszten, Robert E.

“…The study of rare variants may enhance our understanding of the genetic determinants of the metabolome. Here, we analyze the association between 217 plasma…”
Get full text

The circulating metabolome of human starvation by Steinhauser, Matthew L, Olenchock, Benjamin A, O'Keefe, John, Lun, Mingyue, Pierce, Kerry A, Lee, Hang, Pantano, Lorena, Klibanski, Anne, Shulman, Gerald I, Clish, Clary B, Fazeli, Pouneh K

“…The human adaptive starvation response allows for survival during long-term caloric deprivation. Whether the physiology of starvation is adaptive or…”
Get full text

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation by Mitchell, Wayne, Goeminne, Ludger J E, Tyshkovskiy, Alexander, Zhang, Sirui, Chen, Julie Y, Paulo, Joao A, Pierce, Kerry A, Choy, Angelina H, Clish, Clary B, Gygi, Steven P, Gladyshev, Vadim N

“…Partial reprogramming by cyclic short-term expression of Yamanaka factors holds promise for shifting cells to younger states and consequently delaying the…”
Get full text

Metabolomics of Chronic Kidney Disease Progression: A Case-Control Analysis in the Chronic Renal Insufficiency Cohort Study by Rhee, Eugene P, Clish, Clary B, Wenger, Julia, Roy, Jason, Elmariah, Sammy, Pierce, Kerry A, Bullock, Kevin, Anderson, Amanda H, Gerszten, Robert E, Feldman, Harold I

“…Whereas several longitudinal metabolomics studies have been conducted in individuals with normal estimated glomerular filtration rate (eGFR) at baseline,…”
Get more information

Lysine pathway metabolites and the risk of type 2 diabetes and cardiovascular disease in the PREDIMED study: results from two case-cohort studies by Razquin, Cristina, Ruiz-Canela, Miguel, Clish, Clary B, Li, Jun, Toledo, Estefania, Dennis, Courtney, Liang, Liming, Salas-Huetos, Albert, Pierce, Kerry A, Guasch-Ferré, Marta, Corella, Dolores, Ros, Emilio, Estruch, Ramon, Gómez-Gracia, Enrique, Fitó, Montse, Lapetra, Jose, Romaguera, Dora, Alonso-Gómez, Angel, Serra-Majem, Lluis, Salas-Salvadó, Jordi, Hu, Frank B, Martínez-González, Miguel A

“…The pandemic of cardiovascular disease (CVD) and type 2 diabetes (T2D) requires the identification of new predictor biomarkers. Biomarkers potentially…”
Get full text

Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation by Avanesov, Andrei S, Ma, Siming, Pierce, Kerry A, Yim, Sun Hee, Lee, Byung Cheon, Clish, Clary B, Gladyshev, Vadim N

“…Aging is thought to be associated with increased molecular damage, but representative markers vary across conditions and organisms, making it difficult to…”
Get full text

The Role of Adipocyte Insulin Resistance in the Pathogenesis of Obesity-Related Elevations in Endocannabinoids by D'EON, Tara M, PIERCE, Kerry A, ROIX, Jeffery J, TYLER, Andrew, HONG CHEN, TEIXEIRA, Sandra R

“…The Role of Adipocyte Insulin Resistance in the Pathogenesis of Obesity-Related Elevations in Endocannabinoids Tara M. D'Eon , Kerry A. Pierce , Jeffery J…”
Get full text

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection by Olenchock, Benjamin A., Moslehi, Javid, Baik, Alan H., Davidson, Shawn M., Williams, Jeremy, Gibson, William J., Chakraborty, Abhishek A., Pierce, Kerry A., Miller, Christine M., Hanse, Eric A., Kelekar, Ameeta, Sullivan, Lucas B., Wagers, Amy J., Clish, Clary B., Vander Heiden, Matthew G., Kaelin, William G.

Get full text

Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation by Heckel, Emilie, Cagnone, Gael, Agnihotri, Tapan, Cakir, Bertan, Das, Ashim, Kim, Jin Sung, Kim, Nicholas, Lavoie, Geneviève, Situ, Anu, Pundir, Sheetal, Sun, Ye, Wünnemann, Florian, Pierce, Kerry A, Dennis, Courtney, Mitchell, Grant A, Chemtob, Sylvain, Rezende, Flavio A, Andelfinger, Gregor, Clish, Clary B, Roux, Philippe P, Sapieha, Przemyslaw, Smith, Lois Eh, Joyal, Jean-Sébastien

“…Dyslipidemia and autophagy have been implicated in the pathogenesis of blinding neovascular age-related macular degeneration (NV-AMD). VLDL receptor (VLDLR),…”
Get full text

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases by Lloyd-Price, Jason, Arze, Cesar, Ananthakrishnan, Ashwin N., Schirmer, Melanie, Avila-Pacheco, Julian, Poon, Tiffany W., Andrews, Elizabeth, Ajami, Nadim J., Bonham, Kevin S., Brislawn, Colin J., Casero, David, Courtney, Holly, Gonzalez, Antonio, Graeber, Thomas G., Hall, A. Brantley, Lake, Kathleen, Landers, Carol J., Mallick, Himel, Plichta, Damian R., Prasad, Mahadev, Rahnavard, Gholamali, Sauk, Jenny, Shungin, Dmitry, Vázquez-Baeza, Yoshiki, White, Richard A., Braun, Jonathan, Denson, Lee A., Jansson, Janet K., Knight, Rob, Kugathasan, Subra, McGovern, Dermot P. B., Petrosino, Joseph F., Stappenbeck, Thaddeus S., Winter, Harland S., Clish, Clary B., Franzosa, Eric A., Vlamakis, Hera, Xavier, Ramnik J., Huttenhower, Curtis

“…Inflammatory bowel diseases, which include Crohn’s disease and ulcerative colitis, affect several million individuals worldwide. Crohn’s disease and ulcerative…”
Get full text