Search Results - "Pierce, GF"

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response by High, Katherine A, Manno, Catherine S, Pierce, Glenn F, Arruda, Valder R, Glader, Bertil, Ragni, Margaret, Rasko, John J E, Ozelo, Margareth C, Hoots, Keith, Blatt, Philip, Konkle, Barbara, Dake, Michael, Kaye, Robin, Razavi, Mahmood, Zajko, Albert, Zehnder, James, Rustagi, Pradip, Nakai, Hiroyuki, Chew, Amy, Leonard, Debra, Wright, J Fraser, Lessard, Ruth R, Sommer, Jürg M, Tigges, Michael, Sabatino, Denise, Luk, Alvin, Jiang, Haiyan, Mingozzi, Federico, Couto, Linda, Ertl, Hildegund C, Kay, Mark A

“…We have previously shown that a single portal vein infusion of a recombinant adeno-associated viral vector (rAAV) expressing canine Factor IX (F.IX) resulted…”
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Genotypes, Phenotypes, and Whole Genome Sequence: Approaches from the MyLifeOurFuture Haemophilia Project by Konkle, BA, Johnsen, JM, Wheeler, M, Watson, C, Skinner, M, Pierce, GF

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Human immunoglobulin inhibits liver transduction by AAV vectors at low AAV2 neutralizing titers in SCID mice by Scallan, Ciaran D., Jiang, Haiyan, Liu, Tongyao, Patarroyo-White, Susannah, Sommer, Jurg M., Zhou, Shangzhen, Couto, Linda B., Pierce, Glenn F.

“…Long-term cures of hemophilia B have been achieved using AAV2 delivering the factor IX gene to the liver of adeno-associated virus (AAV)–naive hemophilic…”
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Mutations on the External Surfaces of Adeno-Associated Virus Type 2 Capsids That Affect Transduction and Neutralization by Lochrie, Michael A, Tatsuno, Gwen P, Christie, Brian, McDonnell, Jennifer Wellman, Zhou, Shangzhen, Surosky, Richard, Pierce, Glenn F, Colosi, Peter

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Multiyear therapeutic benefit of AAV serotypes 2, 6, and 8 delivering factor VIII to hemophilia A mice and dogs by Jiang, Haiyan, Lillicrap, David, Patarroyo-White, Susannah, Liu, Tongyao, Qian, Xiaobing, Scallan, Ciaran D., Powell, Sandra, Keller, Tracey, McMurray, Morag, Labelle, Andrea, Nagy, Dea, Vargas, Joseph A., Zhou, Shangzhen, Couto, Linda B., Pierce, Glenn F.

“…Hemophilia A, a deficiency of functional coagulation factor VIII (FVIII), is treated via protein replacement therapy. Restoring 1% to 5% of normal blood FVIII…”
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Inflammation in Nonhealing Diabetic Wounds: The Space-Time Continuum Does Matter by Pierce, Glenn F.

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Identification of factors that contribute to recombinant AAV2 particle aggregation and methods to prevent its occurrence during vector purification and formulation by Wright, J Fraser, Le, Tannie, Prado, Joseph, Bahr-Davidson, Jennifer, Smith, Peter H, Zhen, Zhu, Sommer, Jurg M, Pierce, Glenn F, Qu, Guang

“…Aggregation of recombinant AAV2 results in reduced yield during purification and may have deleterious effects on vector transduction efficiency,…”
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AAV2-mediated gene delivery to monkey putamen: Evaluation of an infusion device and delivery parameters by Sanftner, Laura M., Sommer, Jurg M., Suzuki, Brian M., Smith, Peter H., Vijay, Sharmila, Vargas, Joseph A., Forsayeth, John R., Cunningham, Janet, Bankiewicz, Krys S., Kao, Haihwa, Bernal, Jan, Pierce, Glenn F., Johnson, Kirk W.

“…In this study, a modified infusion procedure and a novel infusion device designed for use in humans (Clinical Device B) were evaluated for delivery of…”
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Novel Caprine Adeno-Associated Virus (AAV) Capsid (AAV-Go.1) Is Closely Related to the Primate AAV-5 and Has Unique Tropism and Neutralization Properties by Arbetman, Alejandra E, Lochrie, Michael, Zhou, Shangzhen, Wellman, Jennifer, Scallan, Ciaran, Doroudchi, Mohammad M, Randlev, Britta, Patarroyo-White, Susannah, Liu, Tongyao, Smith, Peter, Lehmkuhl, Howard, Hobbs, Lea Ann, Pierce, Glenn F, Colosi, Peter

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Adenovirus Encoding Human Platelet-Derived Growth Factor-B Delivered in Collagen Exhibits Safety, Biodistribution, and Immunogenicity Profiles Favorable for Clinical Use by Gu, Dan-ling, Nguyen, Thanh, Gonzalez, Ana Maria, Printz, Marie A, Pierce, Glenn F, Sosnowski, Barbara A, Phillips, M Laurie, Chandler, Lois A

“…We have developed a therapeutic approach to wound repair involving immobilization of gene transfer vectors within biocompatible matrices (gene-activated…”
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Delivery of FGF Genes to Wound Repair Cells Enhances Arteriogenesis and Myogenesis in Skeletal Muscle by Doukas, John, Blease, Kate, Craig, Darren, Ma, Chenglie, Chandler, Lois A., Sosnowski, Barbara A., Pierce, Glenn F.

“…Tissue repair is driven by migratory macrophages and fibroblasts that infiltrate injury sites and secrete growth factors. We now report the enhancement of…”
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Improved coagulation in bleeding disorders by Non-Anticoagulant Sulfated Polysaccharides (NASP) by Liu, Tongyao, Scallan, Ciaran D, Broze, Jr, George J, Patarroyo-White, Susanna, Pierce, Glenn F, Johnson, Kirk W

“…Additional therapeutic options are needed for patients with bleeding disorders such as hemophilia A, hemophilia B, severe von Willebrand disease, and other…”
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Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality by FARRELL, C. L, BREADY, J. V, HAVILL, A. M, LU, Z.-N, AUKERMAN, S. L, PIERCE, G. F, THOMASON, A, POTTEN, C. S, ULICH, T. R, LACEY, D. L, REX, K. L, CHEN, J. N, DIPALMA, C. R, WHITCOMB, K. L, SONGMEI YIN, HILL, D. C, WIEMANN, B, STARNES, C. O

“…Keratinocyte growth factor (KGF) stimulates the proliferation and differentiation of epithelial cells including those of the gastrointestinal tract. Although…”
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Gene transfer to mammalian cells using genetically targeted filamentous bacteriophage by Larocca, David, Kassner, Paul D., Witte, Alison, Ladner, Robert Charles, Pierce, Glenn F., Baird, Andrew

“…We have genetically modified filamentous bacteriophage to deliver genes to mammalian cells. In previous studies we showed that noncovalently attached…”
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Detection of platelet-derived growth factor (PDGF)-AA in actively healing human wounds treated with recombinant PDGF-BB and absence of PDGF in chronic nonhealing wounds by Pierce, G F, Tarpley, J E, Tseng, J, Bready, J, Chang, D, Kenney, W C, Rudolph, R, Robson, M C, Vande Berg, J, Reid, P

“…Some human chronic dermal wounds treated with recombinant platelet-derived growth factor-BB (rPDGF-BB) show increased healing coupled with fibroblast…”
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Targeting bacteriophage to mammalian cell surface receptors for gene delivery by Larocca, D, Witte, A, Johnson, W, Pierce, G F, Baird, A

“…Filamentous bacteriophages represent one of nature's most elegant ways of packaging and delivering DNA. In an effort to develop novel methods for ligand…”
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Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo by ULICH, T R, YI, E. S, LONGMUIR, K, SONGMEI YIN, BILTZ, R, MORRIS, C. F, HOUSLEY, R. M, PIERCE, G. F

“…Keratinocyte growth factor (KGF) administered as a single intratracheal injection causes a prominent dose-dependent proliferation of type II alveolar…”
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The Antiproliferative Activity of c-myb and c-myc Antisense Oligonucleotides in Smooth Muscle Cells is Caused by a Nonantisense Mechanism by Burgess, Teresa L., Fisher, Eric F., Ross, Sandra L., Bready, James V., Qian, Yi-Xin, Bayewitch, Leigh A., Cohen, Arthur M., Herrera, Charles J., Sylvia S.-F. Hu, Kramer, Tiffin B., Lott, Fred D., Martin, Frank H., Pierce, Glenn F., Simonet, Lizette, Farrell, Catherine L.

“…Smooth muscle cell (SMC) proliferation is thought to play a major role in vascular restenosis after angioplasty and is a serious complication of the procedure…”
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Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia by Danilenko, DM, Ring, BD, Yanagihara, D, Benson, W, Wiemann, B, Starnes, CO, Pierce, GF

“…The growth and development of hair follicles is influenced by a number of different growth factors and cytokines, particularly members of the fibroblast growth…”
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Keratinocyte growth factor induces proliferation of hepatocytes and epithelial cells throughout the rat gastrointestinal tract by Housley, R M, Morris, C F, Boyle, W, Ring, B, Biltz, R, Tarpley, J E, Aukerman, S L, Devine, P L, Whitehead, R H, Pierce, G F

“…Keratinocyte growth factor (KGF), a member of the fibroblast growth factor (FGF) family, was identified as a specific keratinocyte mitogen after isolation from…”
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